{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:13:55Z","timestamp":1757452435767},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>Opsoclonus-myoclonus syndrome (OMS) may have a toxin induced, parainfectious, or paraneoplastic etiology. Several autoantibodies have been associated with adult-onset OMS, most commonly antineuronal nuclear antibody 2 (Ri), and it is most frequently associated with breast or small cell lung cancer. The nicotinic ganglionic acetylcholine receptor autoantibody (\u03b13-AChR Ab) has not been described in association.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case Report:<\/jats:title>\n            <jats:p>A 46-year-old woman was evaluated for symptoms of oscillopsia, tremor, gait imbalance, and mild cognitive deficits that began 6 weeks prior. Neurological examination demonstrated opsoclonus, myoclonus, and mild gait ataxia. Laboratory evaluation revealed an elevated \u03b13-AChR Ab at 0.27 nmol\/L (normal \u22640.02 nmol\/L) with no other autoantibodies or infectious etiology detected. Thorough screening revealed no evidence of associated malignancy. Immunotherapy with weekly methylprednisolone led to significant improvement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>This first reported case of \u03b13-AChR Ab positivity in the setting of adult-onset OMS expands the spectrum of associated autoantibodies. The mechanism of disease may be linked to cholinergic nuclei within the brainstem. This case suggests including \u03b13-AChR Ab in the evaluation of adult-onset OMS, and highlights the importance of further understanding \u03b13-AChR within the brain.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/nrl.0000000000000098","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T10:22:11Z","timestamp":1477995731000},"page":"99-100","source":"Crossref","is-referenced-by-count":4,"title":["Adult-onset Opsoclonus-Myoclonus Syndrome Associated With Ganglionic Acetylcholine Receptor Autoantibody"],"prefix":"10.1097","volume":"21","author":[{"given":"Jonathan R.","family":"Galli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey L.","family":"Clardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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