{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:51:15Z","timestamp":1789440675249,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1097\/nrl.0b013e318164e53d","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T03:01:14Z","timestamp":1200020474000},"page":"66-73","source":"Crossref","is-referenced-by-count":49,"title":["Does Cervical Manipulative Therapy Cause Vertebral Artery Dissection and Stroke?"],"prefix":"10.1097","volume":"14","author":[{"given":"Madeline L.","family":"Miley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay E.","family":"Wellik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean M.","family":"Wingerchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart M.","family":"Demaerschalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210211","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00415-003-0174-5","article-title":"Cervical artery dissection: clinical features, risk factors, therapy and outcome in 126 patients.","volume":"250","author":"Dziewas","year":"2003","journal-title":"J Neurol"},{"key":"R2-16-20210211","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1161\/01.STR.32.5.1054","article-title":"Chiropractic manipulation and stroke: a population-based case-control study.","volume":"32","author":"Rothwell","year":"2001","journal-title":"Stroke"},{"key":"R3-16-20210211","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s00415-006-0099-x","article-title":"Vertebral artery dissections after chiropractic neck manipulation in Germany over three years.","volume":"253","author":"Reuter","year":"2006","journal-title":"J Neurol"},{"key":"R4-16-20210211","first-page":"50","article-title":"Manipulation of the cervical spine: risks and benefits.","volume":"79","author":"Di Fabio","year":"1999","journal-title":"Phys Therapy"},{"key":"R5-16-20210211","doi-asserted-by":"crossref","first-page":"e01","DOI":"10.1136\/emj.2004.015636","article-title":"Vertebral artery dissection and cerebellar infarction following chiropractic manipulation.","volume":"23","author":"Chen","year":"2006","journal-title":"Emerg Med J"},{"key":"R6-16-20210211","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/01.STR.12.1.2","article-title":"Abrupt change in head position and cerebral infarction.","volume":"12","author":"Sherman","year":"1981","journal-title":"Stroke"},{"key":"R7-16-20210211","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/01.nrl.0000038583.58012.10","article-title":"Association of internal carotid artery dissection and chiropractic manipulation.","volume":"9","author":"Haneline","year":"2003","journal-title":"The Neurologist"},{"key":"R8-16-20210211","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1212\/01.WNL.0000063305.61050.E6","article-title":"Spinal manipulative therapy is an independent risk factor for vertebral artery dissection.","volume":"60","author":"Smith","year":"2003","journal-title":"Neurology"},{"key":"R9-16-20210211","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1177\/014107680710000716","article-title":"Adverse effects of spinal manipulation: a systematic review.","volume":"100","author":"Ernst","year":"2007","journal-title":"J R Soc Med"},{"key":"R10-16-20210211","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1007\/s00415-002-0783-4","article-title":"Stroke, cerebral artery dissection, and cervical spine manipulation therapy.","volume":"249","author":"Haldeman","year":"2002","journal-title":"J Neurol"},{"key":"R11-16-20210211","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1600-0404.2005.00497.x","article-title":"Iatrogenic vertebral artery injury.","volume":"112","author":"Inamasu","year":"2005","journal-title":"Acta Neurol Scand"},{"key":"R12-16-20210211","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00007632-200201010-00012","article-title":"Unpredictability of cerebrovascular ischemia associated with cervical spine manipulation. A review of sixty-four cases after cervical spine manipulation.","volume":"27","author":"Haldeman","year":"2002","journal-title":"Spine"},{"key":"R13-16-20210211","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s004150050432","article-title":"Stroke following manipulation of the cervical spine.","volume":"246","author":"Hufnagel","year":"1999","journal-title":"J Neurol"},{"key":"R15-16-20210211","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000098327","article-title":"Mild mechanical traumas are possible risk factors for cervical artery dissection.","volume":"23","author":"Dittrich","year":"2007","journal-title":"Cerebrovascular Diseases"},{"key":"R16-16-20210211","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jmpt.2004.12.003","article-title":"Cervical artery dissection. A comparison of highly dynamic mechanisms: manipulation versus motor vehicle collision.","volume":"28","author":"Haneline","year":"2005","journal-title":"J Manip Physiol Ther"},{"key":"R17-16-20210211","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1067\/mmt.2002.127076","article-title":"Internal forces sustained by the vertebral artery during spinal manipulative therapy.","volume":"25","author":"Symons","year":"2002","journal-title":"J Manipulative Physiol Ther"},{"key":"R18-16-20210211","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jmpt.2004.04.011","article-title":"The stroke issue: paucity of valid data, plethora of unsubstantiated conjecture.","volume":"27","author":"Chestnut","year":"2004","journal-title":"J Manip Physiol Ther"},{"key":"R19-16-20210211","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jmpt.2004.08.008","article-title":"Flaws in a recent vertebral artery dissection study by smith et al.","volume":"27","author":"Rosner","year":"2004","journal-title":"J Manip Phsiol Ther"},{"key":"R20-16-20210211","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S1529-9430(02)00411-4","article-title":"Clinical perceptions of the risk of vertebral artery dissection after cervical manipulation: the effect of referral bias.","volume":"2","author":"Haldeman","year":"2002","journal-title":"The Spine Journal"},{"key":"R21-16-20210211","first-page":"1059","article-title":"Editorial comment. Chiropractic manipulation and stroke, a population-based case-control study.","volume":"32","author":"Bousser","year":"2001","journal-title":"Stroke"},{"key":"R22-16-20210211","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1212\/WNL.45.6.1213","article-title":"Neurologic complications following chiropractic manipulation: A survey of California neurologists.","volume":"45","author":"Lee","year":"1995","journal-title":"Neurology"},{"key":"R23-16-20210211","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/jama.1974.03230400051034","article-title":"stroke following chiropractic manipulation of the spine.","volume":"229","author":"Miller","year":"1974","journal-title":"JAMA"},{"key":"R24-16-20210211","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00234-003-0944-x","article-title":"Simultaneous bilateral internal carotid and vertebral artery dissection following chiropractic manipulation: case report and review of the literature.","volume":"45","author":"Nadgir","year":"2003","journal-title":"Neuroradiology"},{"key":"R25-16-20210211","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00415-002-0784-3","article-title":"Cerebrovascular complications of therapeutic neck manipulation. The need for reliable data on risks and risk factors.","volume":"249","author":"Rothwell","year":"2002","journal-title":"J Neurol"},{"key":"R26-16-20210211","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1017\/S0317167100001025","article-title":"Vertebral artery dissection: warning symptoms, clinical features and prognosis in 26 patients.","volume":"27","author":"Saeed","year":"2000","journal-title":"Can J Neurol Sci"},{"key":"R27-16-20210211","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1553-2712.1997.tb03666.x","article-title":"Vertebral artery dissection.","volume":"4","author":"Showalter","year":"1997","journal-title":"Acad Emerg Med"},{"key":"R28-16-20210211","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.math.2004.06.004","article-title":"Is it time to stop functional pre-manipulation testing of the cervical spine?","volume":"10","author":"Thiel","year":"2005","journal-title":"Manual Therapy"}],"container-title":["The Neurologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/NRL.0b013e318164e53d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:59:55Z","timestamp":1786035595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00127893-200801000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/nrl.0b013e318164e53d","relation":{},"ISSN":["1074-7931"],"issn-type":[{"value":"1074-7931","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}