{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:18:23Z","timestamp":1790723903106,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1097\/ogx.0b013e318223614c","type":"journal-article","created":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T15:29:33Z","timestamp":1310570973000},"page":"240-247","source":"Crossref","is-referenced-by-count":42,"title":["Folic Acid in Obstetric Practice: A Review"],"prefix":"10.1097","volume":"66","author":[{"given":"Vikram Sinai","family":"Talaulikar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabaratnam","family":"Arulkumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20210212","first-page":"CD007950","article-title":"Effects and safety of periconceptional folate supplementation for preventing birth defects.","author":"De-Regil","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"R2-22-20210212","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1096\/fj.10-165084","article-title":"Folic acid in early pregnancy: a public health success story.","volume":"24","author":"Obican","year":"2010","journal-title":"FASEB J"},{"key":"R3-22-20210212","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1136\/bmj.1.3676.1059","article-title":"Treatment of pernicious anaemia of pregnancy and tropical anaemia with special reference to yeast extract as curative agent.","volume":"1","author":"Wills","year":"1931","journal-title":"Br Med J"},{"key":"R4-22-20210212","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1021\/ja01853a512","article-title":"The concentration of folic acid.","volume":"63","author":"Mitchell","year":"1941","journal-title":"J Am Chem Soc"},{"key":"R5-22-20210212","first-page":"8781","article-title":"Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Final rule. 21 CFR Parts 136, 137, and 139.","volume":"61","year":"1996","journal-title":"Fed Regist"},{"key":"R7-22-20210212","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(96)12049-3","article-title":"Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations.","volume":"349","author":"Molloy","year":"1997","journal-title":"Lancet"},{"key":"R9-22-20210212","first-page":"45","article-title":"Prematurity and maternal folate deficiency: anemia during pregnancy study group results in Valencia, Venezuela.","volume":"54","author":"Mart\u00ed-Carvajal","year":"2004","journal-title":"Arch Latinoam Nutr"},{"key":"R10-22-20210212","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/aje\/kwm373","article-title":"Folic acid and multivitamin supplement use and risk of placental abruption: a population-based registry study.","volume":"167","author":"Nilsen","year":"2008","journal-title":"Am J Epidemiol"},{"issue":"suppl 5","key":"R11-22-20210212","doi-asserted-by":"crossref","first-page":"1295S","DOI":"10.1093\/ajcn\/71.5.1295s","article-title":"Folic acid: influence on the outcome of pregnancy.","volume":"71","author":"Scholl","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"R12-22-20210212","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00439-008-0531-7","article-title":"Reduced folate carrier 80A\u2013>G polymorphism, plasma folate, and risk of placental abruption.","volume":"124","author":"Ananth","year":"2008","journal-title":"Hum Genet"},{"key":"R13-22-20210212","doi-asserted-by":"crossref","first-page":"385.e1","DOI":"10.1016\/j.ajog.2007.06.046","article-title":"Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption.","volume":"197","author":"Ananth","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"R14-22-20210212","first-page":"1","article-title":"Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis\u2014United States, 1985\u20131994.","volume":"44","author":"Cragan","year":"1995","journal-title":"Mor Mortal Wkly Rep"},{"key":"R15-22-20210212","first-page":"455","article-title":"Health Dimensions of Sex and Reproduction: the Global Burden of Sexually Transmitted Diseases, HIV, Maternal Conditions, Perinatal Disorders, and Congenital Anomalies. Vol 3.","author":"Shibuya","year":"1998"},{"key":"R17-22-20210212","first-page":"519","article-title":"Folic acid and congenital malformation: scientific evidence and public health strategies [in Italian].","volume":"20","author":"Salerno","year":"2008","journal-title":"Ann Ig"},{"key":"R18-22-20210212","first-page":"CD004514","article-title":"Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people.","author":"Malouf","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"R19-22-20210212","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/156652409787847146","article-title":"Folic acid, neurodegenerative and neuropsychiatric disease.","volume":"9","author":"Kronenberg","year":"2009","journal-title":"Curr Mol Med"},{"key":"R20-22-20210212","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1586\/ern.09.75","article-title":"Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations.","volume":"9","author":"Stanger","year":"2009","journal-title":"Expert Rev Neurother"},{"key":"R21-22-20210212","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1161\/01.CIR.103.22.2674","article-title":"Low dietary folate intake is associated with an excess incidence of acute coronary events: the kuopio ischemic heart disease risk factor study.","volume":"103","author":"Voutilainen","year":"2001","journal-title":"Circulation"},{"key":"R22-22-20210212","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/hc0102.101388","article-title":"Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine.","volume":"105","author":"Doshi","year":"2002","journal-title":"Circulation"},{"key":"R23-22-20210212","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1161\/hq0701.092000","article-title":"Folate improves endothelial function in coronary artery disease.","volume":"21","author":"Doshi","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R24-22-20210212","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1001\/archinte.161.5.695","article-title":"Randomized trial of folic acid supplementation and serum homocysteine levels.","volume":"161","author":"Wald","year":"2001","journal-title":"Arch Intern Med"},{"key":"R25-22-20210212","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1001\/archinternmed.2010.348","article-title":"Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals.","volume":"170","author":"Clarke","year":"2010","journal-title":"Arch Intern Med"},{"key":"R26-22-20210212","article-title":"Nutrition in Health and Disease.","author":"Herbert","year":"1999"},{"key":"R27-22-20210212","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/ajcn\/77.6.1474","article-title":"Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain.","volume":"77","author":"Mills","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"R28-22-20210212","doi-asserted-by":"crossref","first-page":"3731S","DOI":"10.1093\/jn\/133.11.3731S","article-title":"Role of folate in colon cancer development and progression.","volume":"133","author":"Kim","year":"2003","journal-title":"J Nutr"},{"key":"R29-22-20210212","first-page":"5434","article-title":"Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse.","volume":"60","author":"Song","year":"2000","journal-title":"Cancer Res"},{"key":"R30-22-20210212","first-page":"3191","article-title":"Chemopreventive effects of dietary folate on intestinal polyps in Apc +\/2Msh22\/2 mice.","volume":"60","author":"Song","year":"2000","journal-title":"Cancer Res"},{"key":"R31-22-20210212","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1158\/1055-9965.EPI-07-0329","article-title":"A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis.","volume":"16","author":"Mason","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R32-22-20210212","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1158\/1055-9965.511.13.4","article-title":"Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?","volume":"13","author":"Kim","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R33-22-20210212","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1038\/sj.onc.1207716","article-title":"Diet and cancer prevention.","volume":"23","author":"McCullough","year":"2004","journal-title":"Oncogene"},{"key":"R34-22-20210212","first-page":"179","article-title":"MTHFR Polymorphisms and Disease.","author":"Crott","year":"2005"},{"key":"R35-22-20210212","doi-asserted-by":"crossref","first-page":"2413S","DOI":"10.1093\/jn\/132.8.2413S","article-title":"Folate status: effects on pathways to colorectal carcinogenesis.","volume":"132","author":"Choi","year":"2002","journal-title":"J Nutr"},{"key":"R36-22-20210212","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1182\/blood.V4.2.160.160","article-title":"Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer.","volume":"4","author":"Farber","year":"1949","journal-title":"Blood"},{"key":"R37-22-20210212","first-page":"539","article-title":"Experiments with pteroylglutamic acid and pteroylglutamic acid deficiency in human leukemia [abstract].","volume":"27","author":"Heinle","year":"1948","journal-title":"J Clin Invest"},{"key":"R38-22-20210212","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1001\/jama.297.21.2351","article-title":"Folic acid for the prevention of colorectal adenomas.","volume":"297","author":"Cole","year":"2007","journal-title":"JAMA"},{"key":"R40-22-20210212","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1463-1318.2009.02089.x","article-title":"Folic acid supplementation and colorectal cancer risk: a meta-analysis.","volume":"13","author":"Fife","year":"2011","journal-title":"Colorectal Dis"},{"key":"R41-22-20210212","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.canep.2010.11.004","article-title":"Folate intake and the risk of colorectal cancer: a systematic review and meta-analysis.","volume":"35","author":"Kennedy","year":"2011","journal-title":"Cancer Epidemiol"},{"key":"R42-22-20210212","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s10552-010-9620-8","article-title":"Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer.","volume":"21","author":"Kim","year":"2010","journal-title":"Cancer Causes Control"},{"key":"R43-22-20210212","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3945\/ajcn.110.007781","article-title":"Lee, Walter C Willett, Charles S Fuchs, et al. Folate intake and risk of colorectal cancer and adenoma: modification by time.","volume":"93","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"R44-22-20210212","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/ajcn\/80.5.1123","article-title":"Will mandatory folic acid fortification prevent or promote cancer?","volume":"80","author":"Young-In","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"R45-22-20210212","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1471-0528.1964.tb04317.x","article-title":"The role of folic acid in pregnancy with particular reference to anaemia, abruption and abortion.","volume":"71","author":"Hibbard","year":"1964","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"R46-22-20210212","first-page":"CD001056","article-title":"Periconceptional supplementation with folate and\/or multivitamins for preventing neural tube defects.","author":"Lumley","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"R47-22-20210212","doi-asserted-by":"crossref","first-page":"e7845","DOI":"10.1371\/journal.pone.0007845","article-title":"Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child.","volume":"4","author":"Steegers-Theunissen","year":"2009","journal-title":"PLoS One"},{"key":"R48-22-20210212","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.taap.2003.09.031","article-title":"Gene-nutrient interactions: importance of folates and retinoids during early embryogenesis.","volume":"198","author":"Finnell","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"R49-22-20210212","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/S0140-6736(01)07104-5","article-title":"Quantifying the effect of folic acid.","volume":"358","author":"Wald","year":"2001","journal-title":"Lancet"},{"key":"R50-22-20210212","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study.","volume":"338","year":"1991","journal-title":"Lancet"},{"key":"R51-22-20210212","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ajog.2008.04.021","article-title":"Maternal obesity and risk of neural tube defects: a meta-analysis.","volume":"198","author":"Rasmussen","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"R52-22-20210212","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10654-004-2253-z","article-title":"Body mass index and serum folate in childbearing age women.","volume":"19","author":"Mojtabai","year":"2004","journal-title":"Eur J Epidemiol"},{"key":"R53-22-20210212","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/01.AOG.0000151988.84346.3e","article-title":"Greater maternal weight and the ongoing risk of neural tube defects after folic acid flour fortification.","volume":"105","author":"Ray Joel","year":"2005","journal-title":"Obstet Gynecol"},{"key":"R55-22-20210212","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/FTD.0b013e31819f3340","article-title":"Periconceptional folic acid supplementation: a new indication for therapeutic drug monitoring.","volume":"31","author":"Tam","year":"2009","journal-title":"Ther Drug Monit"},{"key":"R56-22-20210212","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1001\/jama.1995.03530210052030","article-title":"Folate levels and neural tube defects. Implications for prevention.","volume":"274","author":"Daly","year":"1995","journal-title":"JAMA"}],"container-title":["Obstetrical & Gynecological Survey"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/OGX.0b013e318223614c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:23:38Z","timestamp":1686194618000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006254-201104000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/ogx.0b013e318223614c","relation":{},"ISSN":["0029-7828"],"issn-type":[{"value":"0029-7828","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}