{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:33:03Z","timestamp":1786120383692,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1097\/olq.0b013e31823b50c6","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T03:49:57Z","timestamp":1320292197000},"page":"21-24","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and Virologic Response to Episodic Acyclovir for Genital Ulcers Among HIV-1 Seronegative, Herpes Simplex Virus Type 2 Seropositive African Women: A Randomized, Placebo-Controlled Trial"],"prefix":"10.1097","volume":"39","author":[{"given":"Jared M.","family":"Baeten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart E.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinead","family":"Delany-Moretlwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Limbada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godspower","family":"Akpomiemie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Corey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Celum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210213","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.aids.0000198081.09337.a7","article-title":"Herpes simplex virus 2 infection increases HIV acquisition in men and women: Systematic review and meta-analysis of longitudinal studies.","volume":"20","author":"Freeman","year":"2006","journal-title":"AIDS"},{"key":"R2-5-20210213","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1056\/NEJMoa0800260","article-title":"Effect of herpes simplex suppression on incidence of HIV among women in Tanzania.","volume":"358","author":"Watson-Jones","year":"2008","journal-title":"N Engl J Med"},{"key":"R3-5-20210213","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/S0140-6736(08)60920-4","article-title":"Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: A randomized, double-blind, placebo-controlled trial.","volume":"371","author":"Celum","year":"2008","journal-title":"Lancet"},{"key":"R4-5-20210213","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1086\/424519","article-title":"Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract.","volume":"190","author":"Gupta","year":"2004","journal-title":"J Infect Dis"},{"key":"R5-5-20210213","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1086\/651381","article-title":"Clinical and virologic efficacy of herpes simplex virus type 2 suppression by acyclovir in a multicontinent clinical trial.","volume":"201","author":"Fuchs","year":"2010","journal-title":"J Infect Dis"},{"key":"R6-5-20210213","article-title":"Guidelines for the management of sexually transmitted infections.","year":"2003"},{"key":"R7-5-20210213","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2006.","volume":"55","year":"2006","journal-title":"Morb Mortal Wkly Rep"},{"key":"R8-5-20210213","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1128\/JCM.40.7.2609-2611.2002","article-title":"Quantitative stability of DNA after extended storage of clinical specimens as determined by real-time PCR.","volume":"40","author":"Jerome","year":"2002","journal-title":"J Clin Microbiol"},{"key":"R9-5-20210213","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(82)90658-4","article-title":"Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes.","volume":"2","author":"Nilsen","year":"1982","journal-title":"Lancet"},{"key":"R10-5-20210213","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1056\/NEJM198304213081602","article-title":"Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. A randomized double-blind controlled trial in normal subjects.","volume":"308","author":"Bryson","year":"1983","journal-title":"N Engl J Med"},{"key":"R11-5-20210213","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/OLQ.0b013e31815e4190","article-title":"One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection.","volume":"35","author":"Bavaro","year":"2008","journal-title":"Sex Transm Dis"},{"key":"R12-5-20210213","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nm.2006","article-title":"Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.","volume":"15","author":"Zhu","year":"2009","journal-title":"Nat Med"},{"key":"R13-5-20210213","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1086\/605647","article-title":"Improvement in healing and reduction in HIV shedding with episodic acyclovir therapy as part of syndromic management among men: A randomized, controlled trial.","volume":"200","author":"Paz-Bailey","year":"2009","journal-title":"J Infect Dis"},{"key":"R14-5-20210213","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/sti.2009.041814","article-title":"Impact of aciclovir on ulcer healing, lesional, genital and plasma HIV-1 RNA among patients with genital ulcer disease in Malawi.","volume":"86","author":"Phiri","year":"2010","journal-title":"Sex Transm Infect"},{"key":"R15-5-20210213","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1086\/599991","article-title":"Impact of acyclovir on genital and plasma HIV-1 RNA, genital herpes simplex virus type 2 DNA, and ulcer healing among HIV-1-infected African women with herpes ulcers: A randomized placebo-controlled trial.","volume":"200","author":"Mayaud","year":"2009","journal-title":"J Infect Dis"},{"key":"R16-5-20210213","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/OLQ.0b013e3181e212e5","article-title":"Genital ulcer disease treatment policies and access to acyclovir in eight sub-Saharan African countries.","volume":"37","author":"Corbell","year":"2010","journal-title":"Sex Transm Dis"}],"container-title":["Sexually Transmitted Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00007435-201201000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:30:04Z","timestamp":1786048204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00007435-201201000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/olq.0b013e31823b50c6","relation":{},"ISSN":["0148-5717"],"issn-type":[{"value":"0148-5717","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}