{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:40:28Z","timestamp":1728952828817},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Meni\u00e8re\u2019s disease (MD) is an inner ear disease characterized by vertigo attacks, progressive hearing loss, tinnitus, and the sensation of aural fullness. Although the exact pathophysiology of MD is unknown, endolymphatic hydrops is considered to be its histopathological hallmark. It has been suggested that endolymphatic hydrops results from lowered perfusion pressure due to cardiovascular comorbidity. Cardiovascular risk factors can cause cerebral small vessel disease (CSVD), visible on MRI. The presence of CSVD in turn raises the risk of developing a stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>This study aimed to compare the presence of CSVD and cardiovascular risk factors in elderly patients with MD to a control cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Patients diagnosed with MD, aged 50 years and older, were retrospectively reviewed and compared with a control cohort. The primary outcome was the difference in CSVD on MRI imaging, which was assessed by the number of white matter hyperintensities using the ordinal Fazekas scale. The secondary outcome was the presence of brain infarctions on MRI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 111 patients with MD were compared with a control cohort of 111 patients. No difference in the degree of white matter hyperintensities (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.890) was found between the MD and control cohort. Brain infarctions were seen in 8 of 111 patients with MD and 14 of 111 patients from the control cohort (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.261).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>CSVD is not more frequently visible on MRI in elderly patients with MD than in controls. This result does not support hypoperfusion-induced ischemia in the pathophysiology of MD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ono.0000000000000034","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T23:00:07Z","timestamp":1686870007000},"page":"e034","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral Small Vessel Disease in Elderly Patients With Meni\u00e8re\u2019s Disease"],"prefix":"10.1097","volume":"3","author":[{"given":"Fieke K.","family":"Oussoren","sequence":"first","affiliation":[{"name":"Apeldoorn Dizziness Centre, Gelre Hospital, Apeldoorn, The Netherlands"},{"name":"Department of Otorhinolaryngology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roeland B.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Apeldoorn Dizziness Centre, Gelre Hospital, Apeldoorn, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjard R.","family":"Schermer","sequence":"additional","affiliation":[{"name":"Apeldoorn Dizziness Centre, Gelre Hospital, Apeldoorn, The Netherlands"},{"name":"Department of Primary and Community Care, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise N. F.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gelre Hospital, Apeldoorn, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost J.","family":"Kardux","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gelre Hospital, Apeldoorn, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjasse D.","family":"Bruintjes","sequence":"additional","affiliation":[{"name":"Apeldoorn Dizziness Centre, Gelre Hospital, Apeldoorn, The Netherlands"},{"name":"Department of Otorhinolaryngology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"R1-20241014","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/archneur.58.7.1151","article-title":"Prosper M\u00e9ni\u00e8re and his 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