{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:37:55Z","timestamp":1787999875648,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Hypothesis:<\/jats:title>\n            <jats:p>High-resolution parallel transmit T2 sampling perfection with application optimized contrast using different flip angle evolution sequence with improved edge discrimination and semiautomatic determination of nerve cross-sectional area (CSA) can be used to evaluate nerve degeneration in the inner auditory canal (IAC) in long-term deaf patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>In patients with hearing loss, temporal bone MRI is routinely acquired to evaluate the morphology of the nerves within the IAC. Earlier studies have shown that the diameter of the cochlear nerve can be used as prognostic marker for the auditory performance after cochlear implantation in postlingually deaf patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Eighty-two consecutive MRI scans were analyzed using a semiautomatic tool to measure CSA of cranial nerves in the IAC. Results were correlated with patient history and audiology testing as well as with age and gender.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>There was a significant reduced CSA of the cochlear nerve in ears with moderate-to-profound hearing loss and deafness compared with ears with normal hearing, but no significant difference in ears with mild-to-moderate hearing loss compared with normal hearing. In detail, normal hearing ears had a CSA of 1.23\u2009\u00b1\u20090.11\u2009mm<jats:sup>2<\/jats:sup>, whereas ears with pantonal hearing loss of more than 40 dB had 1.02\u2009\u00b1\u20090.05\u2009mm<jats:sup>2<\/jats:sup> (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.026). Maximal CSA of the facial nerve was not different among all groups (average, 1.04\u2009mm<jats:sup>2<\/jats:sup> \u00b1 0.03; linear regression, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.001) and stable with age. However, vestibular nerve CSA decreased significantly with age (average, 1.78\u2009\u00b1\u20090.05\u2009mm<jats:sup>2<\/jats:sup>; linear regression, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.128).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In long-term deaf patients, smaller the diameter of cochlear nerve is the more severe the hearing loss is. The new semiautomatic tool can primarily be used to assess nerve diameter and possibly determine ears with nerve degeneration.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ono.0000000000000047","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T15:35:12Z","timestamp":1706196912000},"page":"e047","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Detection of Reduced Diameter of the Cochlear Nerve in Long-term Deaf Patients Quantified With Semiautomatic Measurement of Nerve Cross-sectional Area Using 3T MRI Data"],"prefix":"10.1097","volume":"4","author":[{"given":"Katrin","family":"Reimann","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Klose","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Ehrenpfordt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kruthika","family":"Thangavelu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3]]},"reference":[{"key":"R1-20241014","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3109\/00016489.2016.1159329","article-title":"Evaluation of cochlear nerve diameter and cross-sectional area in ANSD patients by 30-tesla MRI.","volume":"136","author":"Peng","year":"2016","journal-title":"Acta Otolaryngol"},{"key":"R2-20241014","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1001\/jamaoto.2013.3195","article-title":"Correlation of cochlear nerve size and auditory performance after cochlear implantation in postlingually deaf patients.","volume":"139","author":"Kim","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"R3-20241014","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.amjoto.2005.09.007","article-title":"Cochlear nerve size evaluation in children with sensorineural hearing loss by high-resolution 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