{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:33:29Z","timestamp":1780324409920,"version":"3.54.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Persistent oscillating vertigo (POV) can be triggered by motion, when it is called mal de d\u00e9barquement syndrome (MdDS) but can also occur from nonmotion triggers such as neck injury, inflammation, or homeostatic derangements (nonmotion POV [nmPOV]). The pathology underlying MdDS and nmPOV is unknown but shared symptoms include rocking\/bobbing\/swaying vertigo, headache, cognitive slowing, and fatigue.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We present a case series of patients with MdDS and nmPOV whose symptoms were relieved after treatment of extracranial venous compression in the neck and thoracic outlet.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>POV, regardless of the trigger, was associated with compressions at one or more of the following locations: 1) internal jugular vein (IJV) between the transverse process of the atlas and the styloid process, 2) IJV under the sternocleidomastoid muscle (SCM), and 3) subclavian vein at the thoracic outlet. Compressions were typically bilateral and in tandem. Catheter venography showed dynamic obstruction and shunting of venous blood to the petrosal sinuses around the inner ear and the vertebral veins. Relief of these obstructions with styloidectomy, stenting, neurotoxin to SCM and anterior scalene, SCM partial myotomy, and thoracic outlet decompression significantly relieved POV even with unilateral decompression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Oscillatory perceptions of POV whether MdDS or nmPOV may be from the detection of low amplitude pulsations induced by venous outflow obstruction in areas of high freedom of motion (occipito-atlanto junction, mid-neck, and thoracic outlet). Impaired venous outflow and raised venous pressure around the inner ear could lead to continuous peripheral stimulation of the vestibular system and downstream central effects.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ono.0000000000000065","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T18:05:36Z","timestamp":1738173936000},"page":"e065","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Persistent Oscillating Vertigo From Extracranial Venous Compression"],"prefix":"10.1097","volume":"5","author":[{"given":"Yoon-Hee","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Gharib","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Karam","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Abbott Northwestern Hospital, Minneapolis, Minnesota."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3]]},"reference":[{"key":"R1-20250327","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3233\/VES-200714","article-title":"Mal de debarquement syndrome diagnostic criteria: consensus document of the classification committee of the Barany society.","volume":"30","author":"Cha","year":"2020","journal-title":"J Vestib Res"},{"key":"R2-20250327","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0196-0709(87)80007-8","article-title":"Persistent mal de debarquement syndrome: a motion-induced subjective disorder of balance.","volume":"8","author":"Brown","year":"1987","journal-title":"Am J Otolaryngol"},{"key":"R3-20250327","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/ner.13389","article-title":"Transcranial alternating current stimulation reduces network hypersynchrony and persistent vertigo.","volume":"24","author":"Ahn","year":"2021","journal-title":"Neuromodulation"},{"key":"R4-20250327","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/B978-0-444-63437-5.00028-5","article-title":"Mal de debarquement syndrome.","volume":"137","author":"Hain","year":"2016","journal-title":"Handb Clin Neurol"},{"key":"R5-20250327","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s00415-008-0837-3","article-title":"Clinical features and associated syndromes of mal de debarquement.","volume":"255","author":"Cha","year":"2008","journal-title":"J Neurol"},{"key":"R6-20250327","first-page":"E1653","article-title":"The interconnections of mal de debarquement syndrome and vestibular migraine.","volume":"131","author":"Beh","year":"2021","journal-title":"Laryngoscope"},{"key":"R7-20250327","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fneur.2018.00261","article-title":"Comprehensive clinical profile of mal de debarquement syndrome.","volume":"9","author":"Cha","year":"2018","journal-title":"Front Neurol"},{"key":"R8-20250327","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1177\/1359105314553046","article-title":"The relationship between symptom severity, stigma, illness intrusiveness and depression in mal de debarquement syndrome.","volume":"21","author":"Arroll","year":"2016","journal-title":"J Health Psychol"},{"key":"R9-20250327","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1007\/s00415-011-6349-6","article-title":"Social, societal, and economic burden of mal de debarquement syndrome.","volume":"259","author":"Macke","year":"2012","journal-title":"J Neurol"},{"key":"R10-20250327","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1007\/s00415-021-10767-4","article-title":"Psychological assessment of individuals with mal de debarquement syndrome.","volume":"269","author":"Riley","year":"2021","journal-title":"J Neurol"},{"key":"R11-20250327","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.jvs.2016.04.039","article-title":"Reporting standards of the Society for Vascular Surgery for thoracic outlet syndrome.","volume":"64","author":"Illig","year":"2016","journal-title":"J Vasc Surg"},{"key":"R12-20250327","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/jnis-2023-020440","article-title":"Clinical evaluation of pulsatile tinnitus: history and physical examination techniques to predict vascular etiology.","volume":"16","author":"Cummins","year":"2024","journal-title":"J Neurointerv Surg"},{"key":"R13-20250327","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/neurintsurg-2019-015251","article-title":"A descriptive study of venous sinus pressures and gradients in patients with idiopathic intracranial hypertension.","volume":"12","author":"Fargen","year":"2020","journal-title":"J Neurointerv Surg"},{"key":"R14-20250327","doi-asserted-by":"crossref","first-page":"R377","DOI":"10.1152\/ajpregu.00291.2017","article-title":"Venous collapse regulates intracranial pressure in upright body positions.","volume":"314","author":"Holmlund","year":"2018","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R15-20250327","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1038\/s41598-022-06361-x","article-title":"Deep breathing couples CSF and venous flow dynamics.","volume":"12","author":"Kollmeier","year":"2022","journal-title":"Sci Rep"},{"key":"R16-20250327","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/jmri.24882","article-title":"MRI measurements of intracranial pressure in the upright posture: the effect of the hydrostatic pressure gradient.","volume":"42","author":"Alperin","year":"2015","journal-title":"J Magn Reson Imaging"},{"key":"R17-20250327","doi-asserted-by":"crossref","first-page":"16623","DOI":"10.1038\/s41598-020-73658-0","article-title":"Posture-induced changes in the vessels of the head and neck: evaluation using conventional supine CT and upright CT.","volume":"10","author":"Kosugi","year":"2020","journal-title":"Sci Rep"},{"key":"R18-20250327","doi-asserted-by":"crossref","first-page":"636224","DOI":"10.3389\/fneur.2021.636224","article-title":"Neuroimaging markers of mal de debarquement syndrome.","volume":"12","author":"Cha","year":"2021","journal-title":"Front Neurol"},{"key":"R19-20250327","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fneur.2017.00175","article-title":"Treatment of the mal de debarquement syndrome: a 1-year follow-up.","volume":"8","author":"Dai","year":"2017","journal-title":"Front Neurol"},{"key":"R20-20250327","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/head.13484","article-title":"The spectrum of vestibular migraine: clinical features, triggers, and examination findings.","volume":"59","author":"Beh","year":"2019","journal-title":"Headache"}],"container-title":["Otology &amp; Neurotology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/ONO.0000000000000065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T04:30:36Z","timestamp":1743309036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/ONO.0000000000000065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/ono.0000000000000065","relation":{},"ISSN":["2766-3604"],"issn-type":[{"value":"2766-3604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]}}}