{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:17:25Z","timestamp":1784647045980,"version":"3.55.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Semicircular canal dehiscence (SCD) and vestibular aqueduct (VA) hypoplasia are developmental anomalies associated with distinct inner ear syndromes\u2014SCD syndrome and Meniere\u2019s disease (MD). Our previous work found frequent SCD in MD patients with VA hypoplasia, suggesting a shared developmental origin. To further explore this association, we adopted a reciprocal approach by assessing VA hypoplasia prevalence in patients diagnosed with SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>A total of 219 ears from 173 patients (mean age 53.5 years, standard deviation 16.6 years; 54.3% females) were evaluated for suspected SCD, confirmed by temporal bone computed tomography (CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Radiological analysis of temporal bone CT scans using the angular trajectory of the vestibular aqueduct (ATVA) marker; review of clinical records for diagnosis of MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>Prevalence of VA hypoplasia among SCD patients; association of radiological findings with clinical diagnosis of MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>VA hypoplasia was identified in 4 of 173 patients (2.3%), representing a 46-fold increase compared with the estimated 0.05% prevalence of MD patients with VA hypoplasia in the general population. These cases showed an atypical SCD localization in the posterior limb of the superior semicircular canal. All 4 patients were diagnosed with MD ipsilateral to the SCD\/VA hypoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SCD and VA hypoplasia are associated in a distinct patient group, suggesting a shared developmental etiology. These patients may be predisposed to an early overlap of SCD syndrome and MD, with their clinical course eventually dominated by the progressive nature of MD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/ono.0000000000000079","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:00:23Z","timestamp":1763967623000},"page":"e079","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Vestibular Aqueduct Hypoplasia Identifies Semicircular Canal Dehiscence Patients Who Progress to Meniere\u2019s Disease"],"prefix":"10.1097","volume":"5","author":[{"given":"David","family":"B\u00e4chinger","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Sophie","family":"Franzen","sequence":"additional","affiliation":[{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S.","family":"Kempfle","sequence":"additional","affiliation":[{"name":"Eaton-Peabody Laboratories, Mass Eye and Ear, Boston, MA"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Dalbert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dlugaiczyk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kleinjung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland"},{"name":"University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Juliano","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA"},{"name":"Department of Radiology, Mass Eye and Ear, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Eaton-Peabody Laboratories, Mass Eye and Ear, Boston, MA"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas 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