{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:24:14Z","timestamp":1784849054035,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011779","name":"Brien Holden Vision Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Type and incidence of adverse events and rate of discontinuations for 2 years of daily wear with silicone hydrogel contact lenses in Chinese children with myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred forty children aged 7 to 14 years were enrolled in a prospective randomized clinical trial from November 2008 to April 2009. Children with myopia of up to \u22123.50 diopters (D) spherical equivalent with astigmatism less than or equal to \u22120.75 D were randomized to one commercial and three experimental lens designs of Lotrafilcon B silicone hydrogel lenses (four groups) used bilaterally on a daily wear, monthly replacement schedule. The main outcome measures were incidence per 100 patient\u2010years (incidence, in percentage) of adverse events and rate of discontinuations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no events of microbial keratitis. Fifty\u2010five adverse events (incidence, 14.2%) were seen. There were also 12 recurrent events. The type and incidence percentage were contact lens papillary conjunctivitis (16 events, 4.1%), superior epithelial arcuate lesions (SEALs, six events, 1.5%), corneal erosions (eight events, 2.1%), infiltrative keratitis (five events, 1.3%), asymptomatic infiltrative keratitis (seven events, 1.8%), and asymptomatic infiltrates (13 events, 3.42%). There were differences in the incidence of SEALs between groups (p = 0.023), with the incidence of SEALs being greater with one of the experimental designs. No event resulted in any vision loss. Seventy participants (29.2%) discontinued, with one\u2010third (26 participants, 10.8%) occurring in the first month of lens wear. Discomfort and non\u2013lens\u2010related reasons such as safety concern and disinterest were frequently cited reasons for discontinuations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adverse events with daily wear of silicone hydrogels in children were mainly mechanical in nature, and significant infiltrative events were few. The large number of dropouts in the early days of lens wear and their reasons for discontinuation suggest that adaptation and patient motivation are critical for survival in lens wear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0000000000000017","type":"journal-article","created":{"date-parts":[[2013,8,10]],"date-time":"2013-08-10T09:44:38Z","timestamp":1376127878000},"page":"961-969","source":"Crossref","is-referenced-by-count":34,"title":["Adverse Events during 2 Years of Daily Wear of Silicone Hydrogels in Children"],"prefix":"10.1002","volume":"90","author":[{"given":"Padmaja","family":"Sankaridurg","sequence":"first","affiliation":[{"name":"Brien Holden Vision Institute Sydney New South Wales Australia"},{"name":"Vision Co\u2010operative Research Centre Sydney New South Wales Australia"},{"name":"School of Optometry and Vision Sciences University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Vision Co\u2010operative Research Centre Sydney New South Wales Australia"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Naduvilath","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute Sydney New South Wales Australia"},{"name":"Vision Co\u2010operative Research Centre Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Percy","family":"Lazon de la Jara","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute Sydney New South Wales Australia"},{"name":"Vision Co\u2010operative Research Centre Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Earl L.","family":"Smith","sequence":"additional","affiliation":[{"name":"College of Optometry University of Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ge","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brien A.","family":"Holden","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute Sydney New South Wales Australia"},{"name":"Vision Co\u2010operative Research Centre Sydney New South Wales Australia"},{"name":"School of Optometry and Vision Sciences University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0161-6420(02)01557-9","article-title":"Contact lenses for the treatment of pediatric cataracts","volume":"110","author":"Ma JJ","year":"2003","journal-title":"Ophthalmology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1001\/archophthalmol.2010.101","article-title":"A randomized clinical trial comparing contact lens with intraocular lens correction of monocular aphakia during infancy: grating acuity and adverse events at age 1 year","volume":"128","author":"Lambert SR","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clae.2008.07.001","article-title":"30 Years of contact lens prescribing for keratoconic patients in Turkey","volume":"32","author":"Bilgin LK","year":"2009","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1442-9071.2010.02458.x","article-title":"Keratoconus in Asians: demographics, clinical characteristics and visual function in a hospital\u2010based population","volume":"39","author":"Khor WB","year":"2011","journal-title":"Clin Exp Ophthalmol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/sj.eye.6700159","article-title":"Contact lenses in the management of high anisometropic amblyopia","volume":"16","author":"Roberts CJ","year":"2002","journal-title":"Eye (Lond)"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/01.icl.0000174758.03018.a9","article-title":"Opaque contact lens treatment for older children with amblyopia","volume":"32","author":"Anderson JE","year":"2006","journal-title":"Eye Contact Lens"},{"key":"e_1_2_7_8_1","first-page":"255","article-title":"Daily disposable contact lens wear in myopic children","volume":"81","author":"Walline JJ","year":"2004","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/OPX.0b013e3181dc9a04","article-title":"Gas permeable and soft contact lens wear in children","volume":"87","author":"Jones\u2010Jordan LA","year":"2010","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/ICL.0b013e3181abb5bb","article-title":"Contact lenses in pediatrics study in Singapore","volume":"35","author":"Li L","year":"2009","journal-title":"Eye Contact Lens"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1444-0938.2007.00230.x","article-title":"Bifocal soft contact lenses as a possible myopia control treatment: a case report involving identical twins","volume":"91","author":"Aller TA","year":"2008","journal-title":"Clin Exp Optom"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.ophtha.2010.10.035","article-title":"Effect of dual\u2010focus soft contact lens wear on axial myopia progression in children","volume":"118","author":"Anstice NS","year":"2011","journal-title":"Ophthalmology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1167\/iovs.11-7260","article-title":"Decrease in rate of myopia progression with a contact lens designed to reduce relative peripheral hyperopia: one\u2010year results","volume":"52","author":"Sankaridurg P","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1167\/iovs.10-5485","article-title":"Influence of overnight orthokeratology on axial elongation in childhood myopia","volume":"52","author":"Kakita T","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1097\/01.ico.0000175411.05988.fa","article-title":"Characteristics of Pseudomonas corneal infection related to orthokeratology","volume":"24","author":"Araki\u2010Sasaki K","year":"2005","journal-title":"Cornea"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/archopht.125.5.603","article-title":"Pediatric microbial keratitis in Taiwanese children: a review of hospital cases","volume":"125","author":"Hsiao CH","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0002-9394(14)73016-8","article-title":"Microbial keratitis in children","volume":"117","author":"Clinch TE","year":"1994","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.clae.2009.12.011","article-title":"Twenty first century trends in silicone hydrogel contact lens fitting: an international perspective","volume":"33","author":"Morgan PB","year":"2010","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.ophtha.2005.09.014","article-title":"The incidence of microbial keratitis among wearers of a 30\u2010day silicone hydrogel extended\u2010wear contact lens","volume":"112","author":"Schein OD","year":"2005","journal-title":"Ophthalmology"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.clae.2008.06.004","article-title":"Trends in the use of silicone hydrogel contact lenses for daily wear","volume":"31","author":"Efron N","year":"2008","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.clae.2006.02.008","article-title":"A decade of contact lens prescribing trends in the United Kingdom (1996\u20132005)","volume":"29","author":"Morgan PB","year":"2006","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/ICL.0b013e318030c9b1","article-title":"Adverse events and discontinuations during 18 months of silicone hydrogel contact lens wear","volume":"33","author":"Santodomingo\u2010Rubido J","year":"2007","journal-title":"Eye Contact Lens"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1001\/archophthalmol.2009.313","article-title":"Contact lens\u2010related adverse events and the silicone hydrogel lenses and daily wear care system used","volume":"127","author":"Carnt NA","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/01.opx.0000168588.63897.0f","article-title":"Adverse events and discontinuations with rigid and soft hyper Dk contact lenses used for continuous wear","volume":"82","author":"Morgan PB","year":"2005","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_25_1","first-page":"150","volume-title":"Silicone Hydrogels: The Rebirth of Continuous Wear Contact Lenses","author":"Holden BA","year":"2000"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1097\/00140068-200301001-00051","article-title":"Noninflammatory silicone hydrogel contact lens complications","volume":"29","author":"Dumbleton K","year":"2003","journal-title":"Eye Contact Lens"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/ICL.0b013e31802cc275","article-title":"Inflammatory and mechanical complications associated with 3 years of up to 30 nights of continuous wear of lotrafilcon A silicone hydrogel lenses","volume":"33","author":"Donshik P","year":"2007","journal-title":"Eye Contact Lens"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.opx.0000195565.44486.79","article-title":"Two presentations of contact lens\u2010induced papillary conjunctivitis (CLPC) in hydrogel lens wear: local and general","volume":"83","author":"Skotnitsky CC","year":"2006","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/ICL.0b013e318145a4e5","article-title":"IgE antibody on worn highly oxygen\u2010permeable silicone hydrogel contact lenses from patients with contact lens\u2013induced papillary conjunctivitis (CLPC)","volume":"34","author":"Zhao Z","year":"2008","journal-title":"Eye Contact Lens"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00006324-200212001-00471","article-title":"Patient characteristics and subjective symptoms associated with local and general cases of contact lens induced papillary conjunctivitis (CLPC)","volume":"79","author":"Skotnitsky C","year":"2002","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_31_1","first-page":"125","article-title":"Seven\u2010day extended wear and 30\u2010day continuous wear of high oxygen transmissibility soft silicone hydrogel contact lenses: a randomized 1\u2010year study of 504 patients","volume":"27","author":"Nilsson SE","year":"2001","journal-title":"CLAO J"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/S0161-6420(03)00795-4","article-title":"Comparison of adverse events with daily disposable hydrogels and spectacle wear: results from a 12\u2010monthprospective clinical trial","volume":"110","author":"Sankaridurg PR","year":"2003","journal-title":"Ophthalmology"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/ICL.0b013e318271d3dc","article-title":"Incidence and epidemiologic associations of corneal infiltrates with silicone hydrogel contact lenses","volume":"39","author":"Szczotka\u2010Flynn L","year":"2013","journal-title":"Eye Contact Lens"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/ICL.0b013e3181abb5bb","article-title":"Contact lenses in pediatrics study in Singapore","volume":"35","author":"Li L","year":"2009","journal-title":"Eye Contact Lens"},{"key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1167\/iovs.10-7018","article-title":"Age and other risk factors for corneal infiltrative and inflammatory events in young soft contact lens wearers from the Contact Lens Assessment in Youth (CLAY) study","volume":"52","author":"Chalmers RL","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1167\/iovs.08-2067","article-title":"A randomized trial of the effect of soft contact lenses on myopia progression in children","volume":"49","author":"Walline JJ","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/00006324-199907000-00023","article-title":"Myopia progression in adolescent wearers of soft contact lenses and spectacles","volume":"76","author":"Horner DG","year":"1999","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_38_1","first-page":"83","article-title":"Why one million contact lens wearers dropped out","volume":"27","author":"Young G","year":"2004","journal-title":"Cont Lens Anterior Eye"}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0000000000000017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0000000000000017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0000000000000017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:12:20Z","timestamp":1774951940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0000000000000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1097\/OPX.0000000000000017"],"URL":"https:\/\/doi.org\/10.1097\/opx.0000000000000017","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}