{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:15:01Z","timestamp":1790349301631,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To examine the relationship between uncorrected residual wavefront error and visual performance (VP) in rigid gas permeable (RGP) contact lens\u2010wearing keratoconic eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Seven eyes from six subjects (six moderate, one severe) were studied (mean \u00b1 SD age: 42.71 \u00b1 11.38 years). Significant corneal scarring was an exclusion criterion. Measurements were taken with RGP lenses in place. After pupil dilation, the VP measures of high contrast logMAR visual acuity (VA) and Pelli\u2010Robson contrast sensitivity (PRCS) were measured through a 5\u2010mm artificial pupil. Wavefront error was measured using a Shack\u2013Hartmann wavefront sensor and calculated over 5 mm. For both VP and wavefront error, comparisons were made to previously collected normal values by calculating the interval encompassing 95% of normals, then reporting how many of the seven keratoconic eyes fell outside the normal interval. Additionally, second to sixth order aberrations were processed into four previously reported image quality metrics: root mean square of the wavefront (RMSw), root mean square of the slope (RMSs), average blur strength (Bave) and diameter containing 50% light energy (D50) and regressed against VP measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Five of seven keratoconic eyes fell outside the normal interval (\u22120.23 to 0.09) for VA and two of seven fell outside the normal interval (1.59 to 2.03) for PRCS. Five of seven keratoconic eyes fell outside the normal interval (0.07 to 0.35 \u03bcm) for total higher order RMS. Linear regressions demonstrated relationships between both VA and PRCS and the image quality metrics RMSw, D50, RMSs, and Bave with\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      values for VA = 0.30, 0.30, 0.47, 0.62, and PRCS = 0.21, 0.15, 0.45, 0.75 respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>VP in RGP\u2010wearing keratoconic eyes is reduced and higher order wavefront aberrations are elevated compared to normals. Metrics of retinal image quality demonstrate a relationship between keratoconic VP and residual wavefront aberrations. This relationship suggests developing corrections that more completely correct aberrations may improve visual performance in keratoconus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e31802e64f0","type":"journal-article","created":{"date-parts":[[2007,6,11]],"date-time":"2007-06-11T04:03:26Z","timestamp":1181534606000},"page":"463-470","source":"Crossref","is-referenced-by-count":53,"title":["Uncorrected Wavefront Error and Visual Performance During RGP Wear in Keratoconus"],"prefix":"10.1002","volume":"84","author":[{"given":"Jason D.","family":"Marsack","sequence":"first","affiliation":[{"name":"Visual Optics Institute College of Optometry University of Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina E.","family":"Parker","sequence":"additional","affiliation":[{"name":"Visual Optics Institute College of Optometry University of Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Pesudovs","sequence":"additional","affiliation":[{"name":"NH&amp;MRC Centre for Clinical Eye Research, Department of Ophthalmology, Flinders Medical Centre Flinders University Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"William J.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Visual Optics Institute College of Optometry University of Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Applegate","sequence":"additional","affiliation":[{"name":"Visual Optics Institute College of Optometry University of Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","article-title":"Keratoconus and related noninflammatory corneal thinning disorders","volume":"28","author":"Krachmer JH","year":"1984","journal-title":"Surv Ophthalmol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bjo.2003.027029","article-title":"Contrast and glare testing in keratoconus and after penetrating keratoplasty","volume":"88","author":"Pesudovs K","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/00003226-200011000-00009","article-title":"Corneal scarring and vision in keratoconus: a baseline report from the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study","volume":"19","author":"Zadnik K","year":"2000","journal-title":"Cornea"},{"key":"e_1_2_7_5_1","article-title":"Aberration characterization of abnormal eyes using the large dynamic range Shack\u2010Hartmann wavefront sensor","volume":"45","author":"Pantanelli SM","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_6_1","first-page":"2537","article-title":"Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study","volume":"39","author":"Zadnik K","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_7_1","unstructured":"PesudovsK SarverEJ.Wavefront aberrations arising at the posterior corneal surface in normal and diseased eyes. 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