{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:45:42Z","timestamp":1774953942688,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>The purpose of this study is to contrast the clinical and vision\u2010related quality of life outcomes between Synergeyes, a hybrid contact lens, and Bausch &amp; Lomb Soflens 66 Toric contact lenses in a cross\u2010over design. Also, to determine subject preference of one mode of lens wear over the other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>The Synergeyes lens has a central rigid gas permeable portion made of Paragon HDS100 material (paflufocon D) bonded to the nonionic hydrophilic skirt material of 27% water (PolyHEMA hem\u2010iberfilcon A). The Soflens 66 Toric lens is made of a nonionic hydrophilic 66% water (alphafilcon A) material. Subjects age 18 years and older with spherical refractive error between \u22120.50 and \u22128.00 D and astigmatism correction of \u22120.75 to \u22123.50 D were randomly assigned to wear one mode of contact lens for 1 month then wear the alternate mode for 1 month. Follow\u2010up visits were done at 1 and 4 weeks. Data gathered at these visits included high\u2010contrast log MAR distance visual acuity, average wearing time, comfortable wearing time, over\u2010refraction, and slit lamp observations for corneal edema, conjunctival hyperemia, and corneal staining. At each visit, subjects were asked to rate overall comfort, dryness, and comfortable wearing time. Subjects were asked to complete the NEI\u2010RQL\u201042 questionnaire at the end of each lens wearing period. Upon completion of both lens wearing modes, subjects were asked to choose their preferred mode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Fifty subjects completed the study; 22 (44%) preferred the Synergeyes lenses, and 28 (56%) preferred the Soflens 66 Toric soft lenses. Measured visual acuity was significantly better with the Synergeyes lenses. Of the 13 attributes analyzed in the RQL\u201042, a statistically significant difference between the two modes was found in only one category, \u201csymptoms.\u201d In that category, subjects indicated fewer symptoms when wearing soft lenses. The subjects' ratings also showed significantly more comfort while wearing the soft toric lenses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Bausch &amp; Lomb Soflens 66 Toric lenses were more comfortable and were perceived to produce less symptoms of dryness, itchiness, and lens awareness than Synergeyes lenses. Synergeyes lenses gave better visual acuity than the soft toric lenses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e31811ece4a","type":"journal-article","created":{"date-parts":[[2007,7,10]],"date-time":"2007-07-10T04:11:03Z","timestamp":1184040663000},"page":"593-597","source":"Crossref","is-referenced-by-count":29,"title":["Synergeyes Versus Soft Toric Lenses: Vision\u2010Related Quality of Life"],"prefix":"10.1002","volume":"84","author":[{"given":"Michael J.","family":"Lipson","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Musch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Michigan Ann Arbor Michigan"},{"name":"Visual Science and Epidemiology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Synergeyes Inc.SynergEyes A (paflufocon D\u2014hem\u2010iberfilcon A). Hybrid contact lenses for daily wear. Available at:http:\/\/www.synergeyes.com\/downloads\/A_01.pdf. Accessed April 6 2007."},{"key":"e_1_2_7_3_1","unstructured":"Bausch & Lomb.SofLens 66 Toric (alphafilcon A). Visibility tinted contact lenses. Available at:http:\/\/www.bausch.com\/en_US\/package_insert\/visioncare\/softcontacts\/sftoricinsert.pdf. Accessed April 6 2007."},{"key":"e_1_2_7_4_1","unstructured":"CibaVision.Package Insert for SoftPerm (Synergicon A) Contact Lenses Rigid Center\/Soft Hydrophilic Skirt When Prescribed for Daily Wear. Available at:http:\/\/procare.cibavision.com\/pdf\/softperm.pdf. Accessed April 6 2007."},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1367-0484(99)80044-7","article-title":"The use of hybrid lenses in management of the irregular cornea","volume":"22","author":"Rubinstein MP","year":"1999","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_7_6_1","first-page":"83","article-title":"Effect of Softperm lens wear on corneal thickness and topography: a comparison between keratoconic and normal corneae","volume":"28","author":"Owens H","year":"2002","journal-title":"CLAO J"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00006324-199409000-00001","article-title":"Blink\u2010induced variations in visual performance with toric soft contact lenses","volume":"71","author":"Tomlinson A","year":"1994","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/00006324-200112000-00009","article-title":"On\u2010eye evaluation of optical performance of rigid and soft contact lenses","volume":"78","author":"Hong X","year":"2001","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_9_1","first-page":"11","article-title":"Clinical evaluation of factors influencing toric soft contact lens fit","volume":"79","author":"Young G","year":"2002","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.ophtha.2003.08.021","article-title":"Development of the National Eye Institute refractive error correction quality of life questionnaire: focus groups","volume":"110","author":"Berry S","year":"2003","journal-title":"Ophthalmology"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.ophtha.2002.07.001","article-title":"Psychometric properties of the National Eye Institute\u2010Refractive Error Quality of Life instrument","volume":"110","author":"Hays RD","year":"2003","journal-title":"Ophthalmology"},{"key":"e_1_2_7_12_1","volume-title":"National Eye Institute Refractive Error Quality of Life Instrument (NEI\u2010RQL\u201042), Version 1.0: A Manual for Scoring and Use","author":"Hays RD","year":"2002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/01.opx.0000180818.40127.dc","article-title":"Overnight corneal reshaping versus soft disposable contact lenses: vision\u2010related quality\u2010of\u2010life differences from a randomized clinical trial","volume":"82","author":"Lipson MJ","year":"2005","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/01.opx.0000221401.33776.54","article-title":"The effect of overnight contact lens corneal reshaping on refractive error\u2010specific quality of life","volume":"83","author":"Berntsen DA","year":"2006","journal-title":"Optom Vis 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irregular astigmatism after corneal refractive surgery","volume":"28","author":"Alio JL","year":"2002","journal-title":"J Cataract Refract Surg"}],"container-title":["Optometry and Vision 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