{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:14:48Z","timestamp":1774952088801,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To investigate alterations in prelens tear film (PLTF), contact lens (CL), and postlens tear film (PoLTF) thicknesses and contact lens movement associated with boric acid\u2010containing rewetting drops.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>This was a single\u2010center, randomized, double\u2010masked clinical trial. Following etafilcon A lens application, baseline lens movement and interferometric measures (PLTF, CL, PoLTF thicknesses) were captured. A randomly assigned drop (either a low or high boric acid\u2010containing drops) was applied to both eyes, followed immediately by lens movement and interferometric measures. After a 2\u2010h washout period (spectacle wear), subjects returned for testing with the alternative drop. Statistical analyses addressed pre\u2010 to postdrop changes in lens movement and PLTF, CL, and PoLTF thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>The presence of a drop alone lead to substantial decreases in contact lens movement (general reduction of 0.45 mm), but the reduction was not related to drop type. The presence of a drop led to an increase in PLTF thickness (\u223c0.14 \u03bcm), again regardless of the drop type. Both the general presence of a rewetting drop and drop type lead to an increase in CL center thickness (lower boric acid drop = 0.31 \u03bcm and higher boric acid drop = 1.13 \u03bcm). Both the general presence of a rewetting drop and the drop type lead to a significant decrease in PoLTF thickness, whereby the lower boric acid drop lead to a decrease of 0.28 \u03bcm and the higher boric acid drop lead to a decrease of 0.73 \u03bcm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Boric acid\u2010containing rewetting drops were shown to be associated with a significant reduction in lens movement with a concurrent increase in lens center thickness and reduction in PoLTF thickness. The higher boric acid\u2010containing drop was associated with more substantial increases in lens center thickness and decreases in PoLTF thickness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181694fa9","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T03:13:10Z","timestamp":1206933190000},"page":"236-240","source":"Crossref","is-referenced-by-count":4,"title":["Hydrogel Contact Lens Binding Induced by Contact Lens Rewetting Drops"],"prefix":"10.1002","volume":"85","author":[{"given":"JASON J.","family":"NICHOLS","sequence":"first","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LORAINE T.","family":"SINNOTT","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P EWEN","family":"KING\u2010SMITH","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIDENOBU","family":"NAGAI","sequence":"additional","affiliation":[{"name":"Menicon Co., LTD Research &amp; Development Division Kasugai Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SADAYASU","family":"TANIKAWA","sequence":"additional","affiliation":[{"name":"Menicon Co., LTD Research &amp; Development Division Kasugai Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1167\/iovs.02-0377","article-title":"Thickness of the pre\u2010 and post\u2010contact lens tear film measured in vivo by interferometry","volume":"44","author":"Nichols JJ","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00003226-200308000-00010","article-title":"The effect of eye closure on the post\u2010lens tear film thickness during silicone hydrogel contact lens wear","volume":"22","author":"Nichols JJ","year":"2003","journal-title":"Cornea"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1167\/iovs.04-0149","article-title":"The impact of hydrogel lens settling on the thickness of the tears and contact lens","volume":"45","author":"Nichols JJ","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/01.ico.0000157904.52305.29","article-title":"The impact of contact lens care solutions on the thickness of the tear film and contact lens","volume":"24","author":"Nichols JJ","year":"2005","journal-title":"Cornea"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1167\/iovs.05-0094","article-title":"Thinning rate of the precorneal and prelens tear films","volume":"46","author":"Nichols JJ","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clae.2003.11.002","article-title":"Osmolality and buffering agents in soft contact lens packaging solutions","volume":"27","author":"Lum E","year":"2004","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00006324-199601000-00005","article-title":"Lens adherence and postlens tear film changes in closed\u2010eye wear of hydrogel lenses","volume":"73","author":"Bruce AS","year":"1996","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1475-1313.1995.9598241e.x","article-title":"Osmotic determinants of postlens tear film morphology and hydrogel lens movement","volume":"15","author":"Little SA","year":"1995","journal-title":"Ophthal Physiol Opt"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0420.1995.tb00654.x","article-title":"Soft lens movement: effects of humidity and hypertonic saline on lens settling","volume":"73","author":"Golding TR","year":"1995","journal-title":"Acta Ophthalmol Scand"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1600-0420.1995.tb00325.x","article-title":"Soft lens movement: effect of blink rate on lens settling","volume":"73","author":"Golding TR","year":"1995","journal-title":"Acta Ophthalmol Scand"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/00006324-199406000-00002","article-title":"Hydrogel (Acuvue) lens movement is influenced by the postlens tear film","volume":"71","author":"Little SA","year":"1994","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1475-1313.1994.tb00559.x","article-title":"Postlens tear film morphology, lens movement and symptoms in hydrogel lens wearers","volume":"14","author":"Little SA","year":"1994","journal-title":"Ophthal Physiol Opt"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00006324-199406000-00001","article-title":"Soft lens movement: temporal characteristics","volume":"71","author":"Brennan NA","year":"1994","journal-title":"Optom Vis Sci"}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e3181694fa9","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0b013e3181694fa9","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e3181694fa9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:35:11Z","timestamp":1774949711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0b013e3181694fa9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1097\/OPX.0b013e3181694fa9"],"URL":"https:\/\/doi.org\/10.1097\/opx.0b013e3181694fa9","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}