{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:50:20Z","timestamp":1776329420193,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>The impact of dry eye on everyday living (IDEEL) is a valid, reliable questionnaire with 3 modules; symptom bother (SB), quality of life, and treatment satisfaction. This study tests the utility of the 20\u2010item IDEEL\u2010SB to discrimate self\u2010assessed severity in dry eye subjects and to determine the clinically important difference (CID) in IDEEL\u2010SB score that relates to a self\u2010report of global change in dry eye condition after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>After randomization to 1 of 3 marketed tear replacements, dry eye subjects completed the IDEEL\u2010SB at baseline, 1 and 4 wk and global change questionnaire on status of general health and dry eye at 1 and 4 wk (5\u2010point Likert scale; \u201cmuch better\u201d to \u201cmuch worse\u201d). The IDEEL\u2010SB score was the unweighted mean score \u00d7 25. CID was initially estimated by receiver\u2010operator curve analysis (ROC) and global change questionnaire. Various IDEEL\u2010SB change criteria were tested to maximize % agreement, \u03ba score, and effect size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>The 74 subjects were 54.0 \u00b1 17.2 years old and 52 (70.3%) were female. At baseline, 56.3% rarely\/never used replacement tears. Subjects rated their dry eye severity as mild (41%), moderate (50%), or severe (9%). IDEEL\u2010SB discriminated dry eye severity well; average baseline scores were mild: 40.0 (SD = 7.5), moderate: 50.6 (SD = 11.0) and severe 64.3 (SD = 8.0) (p = 0.001). After 4 wk of drops usage, IDEEL\u2010SB dropped among \u201cimproved\u201d subjects by \u221213.3 (SD = 10.9), \u201csame\u201d shifted by \u22124.7 (SD = 9.4), \u201cworsened\u201d changed by 1.4 (SD = 11.1). ROC results show that a 12\u2010point change in IDEEL\u2010SB is a clinically significant change in symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>12\u2010Point shift in the IDEEL\u2010SB module is a CID based on ROC and the distribution across self\u2010assessed severity groups compared with their global assessment of change in condition with treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181824e0d","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T03:07:22Z","timestamp":1217214442000},"source":"Crossref","is-referenced-by-count":33,"title":["Clinically Important Difference in Dry Eye: Change in IDEEL\u2010Symptom Bother"],"prefix":"10.1002","volume":"85","author":[{"given":"Carol J.","family":"Fairchild","sequence":"first","affiliation":[{"name":"Alcon Laboratories, Ltd. Ft. Worth Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin L.","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Indiana University School of Optometry Bloomington Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn G.","family":"Begley","sequence":"additional","affiliation":[{"name":"Indiana University School of Optometry Bloomington Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1001\/archopht.120.6.804","article-title":"Use of eye care and associated charges among the Medicare population: 1991\u20101998","volume":"120","author":"Ellwein LB","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_8_3_2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF02854841","article-title":"A new look at dry eye disease and its 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