{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:44:00Z","timestamp":1787010240310,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>The purpose of this study is to report the features of dry eye and ocular surface disease in an unusual case of ectrodactyly\u2010ectodermal dysplasia\u2010clefting (EEC) syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report.<\/jats:title>\n                    <jats:p>A single observational case report of a 22\u2010year\u2010old Japanese male with evaporative dry eye and corneal epithelial disease because of lipid layer abnormality resulting from meibomian gland agenesis was treated successfully with low dose lipid base ointment application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion.<\/jats:title>\n                    <jats:p>The clinical features of the dry eye and ocular surface disease and management issues are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Low dose lipid base ointment application may be a promising treatment modality for the ocular surface disease in ectrodactyly\u2010ectodermal dysplasia (EEC)\u2010clefting syndrome, which seems to help in alleviating the subjective complaints and in improving the objective clinical findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e31818527cd","type":"journal-article","created":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T03:25:58Z","timestamp":1219807558000},"source":"Crossref","is-referenced-by-count":10,"title":["Management of Evaporative Dry Eye in Ectrodactyly\u2010Ectodermal Dysplasia\u2010Clefting Syndrome"],"prefix":"10.1002","volume":"85","author":[{"given":"Yu","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Keio University School of Medicine Tokyo 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