{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:32:59Z","timestamp":1774938779974,"version":"3.50.1"},"reference-count":76,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>The purpose of this study is to assess the effect of disease severity on how accurately contact lens fluorescein patterns can be interpreted in keratoconus by clinician assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Two clinicians evaluated fluorescein patterns on 111 eyes of 60 patients with mild (&lt;45 D, 14 eyes), moderate (45 D to 52 D, 61 eyes,) and severe (&gt;52 D, 36 eyes) keratoconus. The masked clinicians were given six contact lenses in random order, the lens that just cleared the corneal apex (the first definite apical clearance lens), three lenses flatter (in 0.1 mm increments), and two lenses steeper (in 0.1 mm increments) than the first definite apical clearance lens. They ranked the lenses from flattest to steepest, based on the fluorescein patterns. The percentage of lenses correctly ranked was determined using (1) exact match with actual; (2) within 0.1 mm of actual; and (3) within 0.2 mm of actual. Accuracy was assessed as the sum of the squared differences between the actual base curve value and each clinician's ranking. Comparison of the mean percentage correctly ranked and accuracy for each keratoconus severity groups was performed using a mixed linear model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Neither percentage correctly ranked (using any of the three protocols) nor accuracy was found to be related to severity of keratoconus (p &gt; 0.15 for all comparisons).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Accuracy of ranking contact lenses in order of base curve radius based on fluorescein pattern assessment by clinicians does not seem to be related to severity of keratoconus. Many factors influence interpretation of fluorescein patterns including all components of the system, fluorescein, tears, cornea, contact lens, external forces, and technique.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181886fb6","type":"journal-article","created":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T03:08:41Z","timestamp":1222657721000},"source":"Crossref","is-referenced-by-count":2,"title":["Fluorescein Pattern Interpretation in Keratoconus"],"prefix":"10.1002","volume":"85","author":[{"given":"Barbara","family":"Fink","sequence":"first","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Heard","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Schafer","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ame Richardson","family":"Cline","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Mitchell","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph T.","family":"Barr","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Optometry Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"2537","article-title":"Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study","volume":"39","author":"Zadnik K","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0161-6420(90)32569-1","article-title":"Clinical management of keratoconus: a multicenter analysis","volume":"97","author":"Lass JH","year":"1990","journal-title":"Ophthalmology"},{"key":"e_1_2_5_4_2","first-page":"313","volume-title":"Contact Lenses","author":"Phillips AJ","year":"1997"},{"key":"e_1_2_5_5_2","first-page":"226","volume-title":"Contact Lens Practice","author":"Mandell RB","year":"1988"},{"key":"e_1_2_5_6_2","first-page":"955","volume-title":"Cornea","author":"Feder RS","year":"2005"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00003226-199603000-00006","article-title":"Biomicroscopic signs and disease severity in keratoconus. 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topography","volume":"35","author":"Accardo PA","year":"2002","journal-title":"J Biomed Inform"},{"key":"e_1_2_5_12_2","volume-title":"Grayson's Disease of the Cornea","author":"Arffa RC","year":"1997"},{"key":"e_1_2_5_13_2","first-page":"889","volume-title":"Smolin and Thoft's The Cornea: Scientific Foundations and Clinical Practice","author":"Rabinowitz YS","year":"2005"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00006324-199703000-00025","article-title":"Keratoconus: age of onset and natural history","volume":"74","author":"Olivares Jimenez JL","year":"1997","journal-title":"Optom Vis Sci"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ophtha.2005.10.009","article-title":"Is there an association between diabetes and keratoconus?","volume":"113","author":"Kuo IC","year":"2006","journal-title":"Ophthalmology"},{"key":"e_1_2_5_16_2","first-page":"52","article-title":"Management of keratoconus: comparative visual assessments","volume":"17","author":"Carney LG","year":"1991","journal-title":"CLAO J"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1136\/bjo.2005.074955","article-title":"Incidence and severity of keratoconus in Asir province, Saudi Arabia","volume":"89","author":"Assiri AA","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ajo.2005.05.029","article-title":"Risk factors for progression to penetrating keratoplasty in patients with keratoconus","volume":"140","author":"Reeves SW","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1444-0938.2004.tb03155.x","article-title":"Keratoconus in Asian eyes at a tertiary eye care facility","volume":"87","author":"Saini JS","year":"2004","journal-title":"Clin Exp Optom"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/00003226-200210000-00008","article-title":"Between\u2010eye asymmetry in keratoconus","volume":"21","author":"Zadnik K","year":"2002","journal-title":"Cornea"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jcrs.2003.11.049","article-title":"Corneal pachymetry in normal and keratoconic eyes: orbscan II versus ultrasound","volume":"30","author":"Gherghel D","year":"2004","journal-title":"J Cataract Refract Surg"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/S0161-6420(02)01276-9","article-title":"Corneal thickness indices discriminate between keratoconus and contact lens\u2010induced corneal thinning","volume":"109","author":"Pflugfelder 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M","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_33_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/00006324-200108000-00011","article-title":"A comparison of two methods of evaluating cornea\u2010to\u2010contact lens base curve fluorescein patterns in keratoconus","volume":"78","author":"Fink BA","year":"2001","journal-title":"Optom Vis Sci"},{"key":"e_1_2_5_34_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00006324-199606000-00003","article-title":"Standardized rigid contact lens fitting protocol for keratoconus","volume":"73","author":"Edrington TB","year":"1996","journal-title":"Optom Vis Sci"},{"key":"e_1_2_5_35_2","first-page":"171","article-title":"The accuracy of fluorescein for determining corneal curvature","volume":"4","author":"Bronstein L","year":"1959","journal-title":"Contacto"},{"key":"e_1_2_5_36_2","unstructured":"BoyerK RicksJ.Accuracy of fluorescein pattern analysis. Senior thesis. Southern California College of Optometry;1984."},{"key":"e_1_2_5_37_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00006324-198904000-00006","article-title":"Aspheric rigid gas permeable contact lenses: practitioner discrimination of base curve increments using fluorescein pattern evaluation","volume":"66","author":"Orsborn GN","year":"1989","journal-title":"Optom Vis Sci"},{"key":"e_1_2_5_38_2","first-page":"973","article-title":"Fluorescein patterns: they are accurate and they can be mastered","volume":"32","author":"Brungardt TF","year":"1961","journal-title":"J Am Optom Assoc"},{"key":"e_1_2_5_39_2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/00006324-199812000-00011","article-title":"Repeatability of refraction and corrected visual acuity in keratoconus. 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Preliminary demonstration","volume":"36","author":"Maeda N","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_59_2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1001\/archopht.1995.01100070044023","article-title":"Comparison of methods for detecting keratoconus using videokeratography","volume":"113","author":"Maeda N","year":"1995","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_5_60_2","first-page":"2290","article-title":"Current keratoconus detection methods compared with a neural network approach","volume":"38","author":"Smolek MK","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_61_2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0886-3350(00)00384-9","article-title":"Keratoconus detection with the KISA% method\u2010another view","volume":"26","author":"Klyce SD","year":"2000","journal-title":"J Cataract Refract 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