{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:40:47Z","timestamp":1792690847519,"version":"4.5.0"},"reference-count":96,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To measure corneal and epithelial thickness across four meridians using Optical Coherence Tomography (OCT) and to compare these measurements between normal non\u2010lens wearers (NLW), rigid gas permeable (RGP) lens wearers, and RGP\u2010wearing keratoconics (KC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Both eyes of 60 subjects were measured (20 NLW, nine female:11 male, 27.6 \u00b1 5.9 years; 20 RGP, 20 female, 23.9 \u00b1 7.6 years; and 20 KC, seven female:13 male, 32.4 \u00b1 8.1 years). A customized fixation target employing LEDs in eight directions of gaze was attached to the OCT and corneal images obtained. Raw OCT scans were analyzed to yield values for corneal and epithelial thickness and color\u2010coded maps were compiled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Central corneal thickness (CCT) was thinnest in KC (447 \u00b1 68 \u03bcm) and similar between RGP (518 \u00b1 32 \u03bcm; p\n                      <jats:sub>KC<\/jats:sub>\n                      &lt; 0.001) and NLW (517 \u00b1 21 \u03bcm) (p\n                      <jats:sub>KC<\/jats:sub>\n                      &lt; 0.001 NLW p\n                      <jats:sub>RGP<\/jats:sub>\n                      &gt; 0.05). Peripheral corneal thickness in NLW was thickest in the superior temporal and thinnest in the inferior (I) regions (superior temporal\n                      <jats:sub>thickest<\/jats:sub>\n                      vs. I\n                      <jats:sub>thinnest<\/jats:sub>\n                      p &lt; 0.001). Central epithelial thickness was thinnest in KC (44 \u00b1 7 \u03bcm), followed by RGP (50 \u00b1 4 \u03bcm), then NLW (54 \u00b1 2 \u03bcm) (p\n                      <jats:sub>KC<\/jats:sub>\n                      &lt; 0.001 NLW p\n                      <jats:sub>RGP<\/jats:sub>\n                      &lt; 0.05). Central epithelial thickness in the KC group was significantly thinner than in the RGP group (p &lt; 0.001). In the NLW group, peripheral epithelial thickness was thicker (63 \u00b1 5 \u03bcm) than central (p &lt; 0.001) and was thickest in the superior (S) region and thinnest in the inferior (I) region (S\n                      <jats:sub>thickest<\/jats:sub>\n                      vs. I\n                      <jats:sub>thinnest<\/jats:sub>\n                      p &lt; 0.001). KC epithelium was thinnest in the inferior temporal meridian (42 \u00b1 5 \u03bcm).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Thickness of the normal cornea and epithelium was greatest in the superior region. In all groups, the inferior cornea and epithelium was thinnest, and to a greater extent in the KC group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e318188892c","type":"journal-article","created":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T03:08:41Z","timestamp":1222657721000},"source":"Crossref","is-referenced-by-count":78,"title":["Thickness Mapping of the Cornea and Epithelium Using Optical Coherence Tomography"],"prefix":"10.1002","volume":"85","author":[{"given":"Sameena","family":"Haque","sequence":"first","affiliation":[{"name":"Centre for Contact Lens Research School of Optometry University of Waterloo Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndon","family":"Jones","sequence":"additional","affiliation":[{"name":"Centre for Contact Lens Research School of Optometry University of Waterloo Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trefford","family":"Simpson","sequence":"additional","affiliation":[{"name":"Centre for Contact Lens Research School of Optometry University of Waterloo Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/bjo.2004.062927","article-title":"Central corneal thickness and progression of the visual field and optic disc in glaucoma","volume":"89","author":"Chauhan BC","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00417-005-0053-0","article-title":"Central and paracentral corneal pachymetry in patients with normal tension glaucoma and ocular hypertension","volume":"244","author":"Jordan JF","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.eye.6700669","article-title":"Comparison of Orbscan and ultrasound pachymetry in the measurement of central corneal thickness","volume":"18","author":"Radford SW","year":"2004","journal-title":"Eye"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.ophtha.2003.09.027","article-title":"Central corneal thickness measurements with partial coherence interferometry, ultrasound, and the Orbscan system","volume":"111","author":"Rainer G","year":"2004","journal-title":"Ophthalmology"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/bjo.2003.030361","article-title":"Comparison of corneal thickness measurements using Orbscan II, non\u2010contact specular microscopy, and ultrasonic pachymetry in eyes after laser in situ keratomileusis","volume":"88","author":"Kawana K","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0161-6420(02)01298-8","article-title":"Reliability of pachymetric measurements using Orbscan after excimer refractive surgery","volume":"110","author":"Prisant O","year":"2003","journal-title":"Ophthalmology"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00006324-200306000-00009","article-title":"Measuring central corneal thickness with ultrasound pachymetry","volume":"80","author":"Realini T","year":"2003","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000071347","article-title":"Effects of extended\u2010wear soft contact lenses on the ocular surface and central corneal thickness","volume":"217","author":"Gurdal C","year":"2003","journal-title":"Ophthalmologica"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0886-3350(02)01921-1","article-title":"Comparison of central corneal thickness measurements by specular microscopy, ultrasound pachymetry, and ultrasound biomicroscopy","volume":"29","author":"Tam ES","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"e_1_2_7_11_2","unstructured":"SalletG. 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