{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:25:04Z","timestamp":1775085904739,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>Microbial keratitis (MK) is a serious sight\u2010threatening complication occurring with and without contact lens wear. The task of diagnosing MK is difficult because each presentation of the disease is different and can be mistaken for noninfectious ulcers such as contact lens peripheral ulcer (CLPU). The purpose of this article is to present a case report of MK initially diagnosed as a CLPU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report.<\/jats:title>\n                    <jats:p>We report the incidence of a 21\u2010year\u2010old female presenting with signs and symptoms in her left eye, which initially suggested a CLPU. At the 24\u2010h follow\u2010up, contrary to expected indications of healing, her condition had deteriorated. The diagnosis was reevaluated as an MK. Ciloxan was prescribed under care of an ophthalmologist. Despite initial misdiagnosis, due to aggressive topical treatment and the peripheral location of the lesion, &lt;1 line of vision was lost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion.<\/jats:title>\n                    <jats:p>Defined signs and symptoms criteria have been established for the differential diagnoses of MK and CLPU. However, there is often an overlap in the signs and symptoms that can complicate the diagnosis. A critical sign, however, is progress immediately after lens wear is discontinued. Prophylaxis and rapid appropriate treatment and follow\u2010up are vitally important if there is any doubt and to ensure correct diagnosis and resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Any diagnosis of CLPU must be monitored carefully to ensure it is not MK. Prompt diagnosis and treatment of MK are essential for a good visual outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181ae0084","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T03:19:53Z","timestamp":1245986393000},"source":"Crossref","is-referenced-by-count":9,"title":["Prompt Diagnosis and Treatment of Microbial Keratitis in a Daily Wear Lens"],"prefix":"10.1002","volume":"86","author":[{"given":"Jennie","family":"Diec","sequence":"first","affiliation":[{"name":"International Clinical Trials Centre New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Carnt","sequence":"additional","affiliation":[{"name":"International Clinical Trials Centre New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Tilia","sequence":"additional","affiliation":[{"name":"International Clinical Trials Centre New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Evans","sequence":"additional","affiliation":[{"name":"International Clinical Trials Centre New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vallam","family":"Rao","sequence":"additional","affiliation":[{"name":"International Clinical Trials Centre New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Ozkan","sequence":"additional","affiliation":[{"name":"International Clinical Trials Centre New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brien A.","family":"Holden","sequence":"additional","affiliation":[{"name":"Institute for Eye Research New South Wales Australia"},{"name":"Sydney, and School of Optometry and Vision Science The University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00003226-200307000-00009","article-title":"Clinical characterization of corneal infiltrative events observed with soft contact lens wear","volume":"22","author":"Sweeney DF","year":"2003","journal-title":"Cornea"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1097\/00140068-200301001-00017","article-title":"Differential diagnosis of microbial keratitis and contact lens\u2010induced peripheral ulcer","volume":"29","author":"Aasuri MK","year":"2003","journal-title":"Eye Contact Lens"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/00003226-199909000-00004","article-title":"Contact lens\u2010induced peripheral ulcers with extended wear of disposable hydrogel lenses: histopathologic observations on the nature and type of corneal infiltrate","volume":"18","author":"Holden BA","year":"1999","journal-title":"Cornea"},{"key":"e_1_2_5_5_2","first-page":"90","volume-title":"Silicone Hydrogels: Continuous Wear Contact Lenses","author":"Willcox MD","year":"2004"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1167\/iovs.06-0564","article-title":"Factors affecting the morbidity of contact lens\u2010related microbial keratitis: a population study","volume":"47","author":"Keay L","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1367-0484(02)00009-7","article-title":"Adverse events with silicone hydrogel continuous wear","volume":"25","author":"Dumbleton K","year":"2002","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.ophtha.2008.04.002","article-title":"The incidence of contact lens\u2010related microbial keratitis in Australia","volume":"115","author":"Stapleton F","year":"2008","journal-title":"Ophthalmology"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/ICL.0b013e318157d86b","article-title":"Are inflammatory events a marker for an increased risk of microbial keratitis?","volume":"33","author":"Sweeney DF","year":"2007","journal-title":"Eye Contact Lens"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ophtha.2005.08.013","article-title":"Microbial keratitis predisposing factors and morbidity","volume":"113","author":"Keay L","year":"2006","journal-title":"Ophthalmology"}],"container-title":["Optometry and Vision 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