{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:45:01Z","timestamp":1790649901914,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>Lid wiper epitheliopathy (LWE) and lid parallel conjunctival folds (LIPCOF) give moderate prediction levels for dryness symptoms in experienced contact lens (CL) wearers. This study investigated whether a combination of LWE and LIPCOF plus other tear film tests and subjective evaluation before contact lens fitting was better able to predict CL\u2010induced dry eye (CLIDE) symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Tear meniscus height, non\u2010invasive break\u2010up time (NIBUT), ocular hyperaemia, LIPCOF, phenol red thread test, corneal and conjunctival staining, and LWE of the right eye of 33 new soft CL wearers (12 males, 21 females, median age = 30.5 years; range = 19 to 44) were assessed in a prospective 2\u2010mo longitudinal study. Symptoms were evaluated by the Ocular Surface Disease Index (OSDI) and subjects were grouped according to their response in the Contact Lens Dry Eye Questionnaire (CLDEQ) during the study (20 symptomatic and 13 asymptomatic). The subjects were fitted with vifilcon A and senofilcon A lenses for a 2\u2010week period, consecutively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Limbal hyperaemia (repeated measures analysis of variance; p &lt; 0.05) and LWE (Friedman; p &lt; 0.004) increased significantly during the study but not LIPCOF (p \u2265 0.318; temporal, nasal, and Sum), bulbar hyperaemia (p = 0.432), staining (p \u2265 0.060), OSDI (p = 0.126), or CLDEQ (p = 0.317, \u03ba = 0.279). Limbal hyperaemia significantly decreased in senofilcon A lenses. Wearing comfort among symptomatics was significantly better with senofilcon A (p = 0.005). At the enrolment visit, the subjects who became symptomatic exhibited significantly decreased NIBUT and increased LIPCOF and OSDI (range, p &lt; 0.027). The best test combination to predict CLIDE (logistic regression analyses) was LIPCOF Sum plus NIBUT and OSDI, (positive predictive value = 87% and accuracy = 91%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>LIPCOF, NIBUT, and OSDI are significant discriminators for CLIDE in new CL wearers compared with hyperaemia, tear meniscus height, phenol red thread test, staining, and LWE. The best test combination is NIBUT plus LIPCOF Sum and OSDI (named the Contact\u2010Lens\u2010Predicting\u2010Test).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181b598cd","type":"journal-article","created":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T03:12:51Z","timestamp":1251429171000},"source":"Crossref","is-referenced-by-count":90,"title":["A Novel Method to Predict the Dry Eye Symptoms in New Contact Lens Wearers"],"prefix":"10.1002","volume":"86","author":[{"given":"Heiko","family":"Pult","sequence":"first","affiliation":[{"name":"School of Optometry and Vision Sciences Contact Lens and Anterior Eye Research (CLAER) Unit Cardiff University Wales United Kingdom"},{"name":"Optometry and Vision Research Weinheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Sciences Contact Lens and Anterior Eye Research (CLAER) Unit Cardiff University Wales United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Purslow","sequence":"additional","affiliation":[{"name":"Optometry and Vision Research Weinheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clae.2007.11.005","article-title":"Demographics of UK contact lens prescribing","volume":"31","author":"Morgan PB","year":"2008","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.clae.2006.02.008","article-title":"A decade of contact lens prescribing trends in the United Kingdom (1996\u20132005)","volume":"29","author":"Morgan PB","year":"2006","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_7_4_2","first-page":"14","article-title":"How can we avoid CL drop\u2010outs?","volume":"222","author":"Pritchard N","year":"2001","journal-title":"Optician"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0892-8967(01)00040-2","article-title":"Discontinuation of contact lens wear: a survey","volume":"26","author":"Pritchard N","year":"1999","journal-title":"Int Contact Lens Clin"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/01.ico.0000248382.32143.86","article-title":"Frequency of and factors associated with contact lens dissatisfaction and discontinuation","volume":"26","author":"Richdale K","year":"2007","journal-title":"Cornea"},{"key":"e_1_2_7_7_2","first-page":"140","article-title":"Discontinuation of contact lens wear","volume":"70","author":"Weed K","year":"1993","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_8_2","unstructured":"D\u00f6hrC.Contact lens wearing comfort. 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