{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:49:18Z","timestamp":1774972158514,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>The purpose of this pilot study was to determine the efficacy of ketorolac tromethamine 0.4% for pain management in conjunction with rigid gas permeable contact lenses in keratoconus. Any potential side effects and complications of this application were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A total of 12 current keratoconus patients who were presently experiencing discomfort or pain associated with their rigid gas permeables for keratoconus and\/or who were contact lens\u2010intolerant were identified from the existing patient population at the SUNY University Optometric Center. Symptomatic subjects were identified through positive feedback to a study Inclusion Questionnaire mailed to their homes. Subjects were treated on the basis of each eye separately in a modified monocular trial that spanned 5 weeks. After establishing that all inclusion and exclusion criteria were met, subjects were instructed to first use an unlabeled bottle of artificial tear solution (placebo) for 2 weeks, and then an unmarked bottle of ketorolac tromethamine 0.4% for 2 weeks in the designated eye. One drop was instilled twice a day, and the eye not assigned to take the drops served as the control. Subjects were monitored through weekly follow\u2010up visits and repeated Keratoconus Symptom and Severity Questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Responses from the Keratoconus Symptom and Severity Questionnaire were analyzed using a 2\u2010factor Repeated Measures Analysis of Variance. Among the small subject subset, there was no statistically significant predilection for the ketorolac tromethamine 0.4% in managing the discomfort and pain associated with keratoconus. The artificial tear solution appeared to be equally effective in improving comfort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>There was no conclusive result as to the efficacy of the ketorolac tromethamine 0.4% vs. the artificial tear solution in the pain management of keratoconus. This could be attributed to a number of physiological and situational factors, as well as small sample size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181c75170","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T02:11:31Z","timestamp":1264471891000},"page":"125-130","source":"Crossref","is-referenced-by-count":8,"title":["Use of Acular LS in the Pain Management of Keratoconus: A Pilot Study"],"prefix":"10.1002","volume":"87","author":[{"given":"Jessica O.","family":"Yu","sequence":"first","affiliation":[{"name":"Clinical Sciences, Contact Lens Research Group, SUNY State College of Optometry New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph E.","family":"Gundel","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Contact Lens Research Group, SUNY State College of Optometry New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","article-title":"Keratoconus and related noninflammatory corneal thinning disorders","volume":"28","author":"Krachmer JH","year":"1984","journal-title":"Surv Ophthalmol"},{"key":"e_1_2_8_3_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"Rabinowitz YS","year":"1998","journal-title":"Surv Ophthalmol"},{"key":"e_1_2_8_4_2","first-page":"2537","article-title":"Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study","volume":"39","author":"Zadnik K","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_8_5_2","first-page":"574","article-title":"A summary of the findings from the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. CLEK Study Group","volume":"72","author":"Szczotka LB","year":"2001","journal-title":"Optometry"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/00006324-198709000-00009","article-title":"Contact lens fitting relation and visual acuity in keratoconus","volume":"64","author":"Zadnik K","year":"1987","journal-title":"Am J Optom Physiol Opt"},{"key":"e_1_2_8_7_2","first-page":"487","article-title":"Keratoconus. Contact lens or keratoplasty?","volume":"95","author":"Smiddy WE","year":"1988","journal-title":"Ophthalmology"},{"key":"e_1_2_8_8_2","first-page":"335","article-title":"Keratoconus. Evaluation of recent trends in the surgical and nonsurgical correction of keratoconus","volume":"95","author":"Belin MW","year":"1988","journal-title":"Ophthalmology"},{"key":"e_1_2_8_9_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00003226-199603000-00006","article-title":"Biomicroscopic signs and disease severity in keratoconus. Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study Group","volume":"15","author":"Zadnik K","year":"1996","journal-title":"Cornea"},{"key":"e_1_2_8_10_2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ophtha.2004.11.050","article-title":"Inflammatory molecules in the tears of patients with keratoconus","volume":"112","author":"Lema I","year":"2005","journal-title":"Ophthalmology"},{"key":"e_1_2_8_11_2","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/ICO.0b013e31816a3591","article-title":"Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects","volume":"27","author":"Lema I","year":"2008","journal-title":"Cornea"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ajo.2004.04.031","article-title":"Quality of life in keratoconus","volume":"138","author":"Kymes SM","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_8_13_2","first-page":"36","article-title":"Using NSAIDs in eye care","volume":"37","author":"DiMartino RB","year":"2002","journal-title":"Optom Manag"},{"key":"e_1_2_8_14_2","first-page":"130","article-title":"When medications cause a corneal melt, do you know what to do?","volume":"35","author":"Schmidt E","year":"2000","journal-title":"Optom Manag"},{"key":"e_1_2_8_15_2","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0161-6420(00)00538-8","article-title":"Keratitis, ulceration, and perforation associated with topical nonsteroidal anti\u2010inflammatory drugs","volume":"108","author":"Guidera AC","year":"2001","journal-title":"Ophthalmology"},{"key":"e_1_2_8_16_2","first-page":"244","article-title":"Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy","volume":"35","author":"Todd PA","year":"1988","journal-title":"Drugs"},{"key":"e_1_2_8_17_2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0886-3350(98)80230-7","article-title":"Corneal penetration of diclofenac from a fixed combination of diclofenac\u2010gentamicin eyedrops","volume":"24","author":"Killer HE","year":"1998","journal-title":"J Cataract Refract Surg"}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e3181c75170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0b013e3181c75170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e3181c75170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:48:41Z","timestamp":1774936121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0b013e3181c75170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1097\/OPX.0b013e3181c75170"],"URL":"https:\/\/doi.org\/10.1097\/opx.0b013e3181c75170","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}