{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:45:52Z","timestamp":1788479152625,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Sight\u2010threatening microbial keratitis associated with contact lens wear remains a serious concern for patients, eye\u2010care practitioners, and the contact lens industry. Several decades of research and some major advances in lens and solution technology have not resulted in a decline in disease incidence. Here, we offer a perspective on the complex pathogenesis of microbial keratitis, the factors that have prevented a better understanding of this disease, and new approaches being used to tackle this important clinical problem.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181d408ee","type":"journal-article","created":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T05:37:54Z","timestamp":1269581874000},"page":"225-232","source":"Crossref","is-referenced-by-count":59,"title":["Pathogenesis of Contact Lens\u2010Associated Microbial Keratitis"],"prefix":"10.1002","volume":"87","author":[{"given":"Suzanne M. J.","family":"Fleiszig","sequence":"first","affiliation":[{"name":"School of Optometry and Graduate Programs in Vision Science Microbiology, Infectious Disease and Immunity, and Health and Medical Sciences University of California\u2010Berkeley Berkeley California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Evans","sequence":"additional","affiliation":[{"name":"School of Optometry and Graduate Programs in Vision Science Microbiology, Infectious Disease and Immunity, and Health and Medical Sciences University of California\u2010Berkeley Berkeley California"},{"name":"College of Pharmacy Touro University California Vallejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0140-6736(98)09385-4","article-title":"Incidence of contact\u2010lens\u2010associated microbial keratitis and its related morbidity","volume":"354","author":"Cheng KH","year":"1999","journal-title":"Lancet"},{"key":"e_1_2_4_3_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/ICO.0b013e318156cb1f","article-title":"A longitudinal study of trends in keratitis in Australia","volume":"27","author":"Green M","year":"2008","journal-title":"Cornea"},{"key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1136\/bjo.2008.151167","article-title":"Epidemiological characteristics, predisposing factors and microbiological profiles of infectious corneal ulcers: the Portsmouth corneal ulcer study","volume":"93","author":"Ibrahim YW","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_4_5_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/sj.eye.6702953","article-title":"Characteristics of and risk factors for contact lens\u2010related microbial keratitis in a tertiary referral hospital","volume":"23","author":"Edwards K","year":"2009","journal-title":"Eye (Lond)"},{"key":"e_1_2_4_6_2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.ophtha.2008.04.002","article-title":"The incidence of contact lens\u2010related microbial keratitis in Australia","volume":"115","author":"Stapleton F","year":"2008","journal-title":"Ophthalmology"},{"key":"e_1_2_4_7_2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1056\/NEJM198909213211201","article-title":"The relative risk of ulcerative keratitis among users of daily\u2010wear and extended\u2010wear soft contact lenses. A case\u2010control study. Microbial Keratitis Study Group","volume":"321","author":"Schein OD","year":"1989","journal-title":"N Engl J Med"},{"key":"e_1_2_4_8_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/bjo.2004.052688","article-title":"Incidence of keratitis of varying severity among contact lens wearers","volume":"89","author":"Morgan PB","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_4_9_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2003.10.002","article-title":"Corneal response to Pseudomonas aeruginosa infection","volume":"23","author":"Hazlett LD","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1542-0124(12)70612-2","article-title":"Life at the front: dissecting bacterial\u2010host interactions at the ocular surface","volume":"5","author":"Evans DJ","year":"2007","journal-title":"Ocul Surf"},{"key":"e_1_2_4_11_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/OPX.0b013e3180439c3e","article-title":"Pseudomonas aeruginosa infection and inflammation during contact lens wear: a review","volume":"84","author":"Willcox MD","year":"2007","journal-title":"Optom Vis Sci"},{"key":"e_1_2_4_12_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1542-0124(12)70279-3","article-title":"Toll\u2010like receptors at the ocular surface","volume":"6","author":"Pearlman E","year":"2008","journal-title":"Ocul Surf"},{"key":"e_1_2_4_13_2","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1128\/iai.62.6.2478-2482.1994","article-title":"Corneal virulence of Staphylococcus aureus: roles of alpha\u2010toxin and protein A in pathogenesis","volume":"62","author":"Callegan MC","year":"1994","journal-title":"Infect Immun"},{"key":"e_1_2_4_14_2","first-page":"866","article-title":"The Glenn A. 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The impact of inoculation parameters on the pathogenesis of contact lens related infectious keratitis.Invest Ophthalmol Vis Sci2010Feb 3. 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