{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:52:28Z","timestamp":1774943548477,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To compare optical coherence tomography (OCT) and scanning laser polarimetry (GDx) measurements of the retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) patients with and without optic neuritis (ON).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>OCT and GDx were performed on 68 MS patients. Qualifying eyes were divided into two groups: 51 eyes with an ON history \u22656 months before (ON eyes) and 65 eyes with no history of ON (non\u2010ON eyes). Several GDx and OCT parameters and criteria were used to define an eye as abnormal, for example, GDx nerve fiber indicator (NFI) &gt;20 or 30, OCT average RNFL thickness, and GDx temporal\u2010superior\u2010nasal\u2010inferior\u2010temporal average (TSNIT) below 5 or 1% of the normative database of the instruments. Agreement between OCT and GDx parameters was reported as percent of observed agreement, along with the AC1 statistic. Linear regression analyses were used to examine the relationship between OCT average RNFL thickness and GDx NFI and TSNIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      All OCT and GDx measurements showed significantly more RNFL damage in ON than in non\u2010ON eyes. Agreement between OCT and GDx parameters ranged from 69 to 90% (AC1 0.37 to 0.81) in ON eyes and 52 to 91% (AC1 = 0.21 to 0.90) in non\u2010ON eyes. Best agreement was observed between OCT average RNFL thickness (p &lt; 0.01) and NFI (&gt;30) in ON eyes (90%, AC1 = 0.81) and between OCT average RNFL thickness (p &lt; 0.01) and GDx TSNIT average (p &lt; 0.01) in non\u2010ON eyes (91%, AC1 = 0.90). In ON eyes, the OCT average RNFL thickness showed good linear correlation with NFI (R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.69, p &lt; 0.0001) and TSNIT (R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.55, p &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>OCT and GDx show good agreement and can be useful in detecting RNFL loss in MS\/ON eyes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181e3dcb3","type":"journal-article","created":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T08:49:31Z","timestamp":1274431771000},"page":"576-584","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of Optical Coherence Tomography and Scanning Laser Polarimetry Measurements in Patients with Multiple Sclerosis"],"prefix":"10.1002","volume":"87","author":[{"given":"Amanda","family":"Quelly","sequence":"first","affiliation":[{"name":"University of Houston College of Optometry Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Houston College of Optometry Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Laron","sequence":"additional","affiliation":[{"name":"University of Houston College of Optometry Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade S.","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology Department of Head and Neck Surgery University of Texas M. 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Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa A.","family":"Tang","sequence":"additional","affiliation":[{"name":"University of Houston MS Eye CARE Clinic Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,1]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"96","article-title":"Optic neuritis","volume":"99","author":"Cantore WA","year":"1996","journal-title":"Pa Med"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1212\/WNL.53.3.473","article-title":"Optic neuritis as onset manifestation of multiple sclerosis: a nationwide, long\u2010term survey","volume":"53","author":"Sorensen TL","year":"1999","journal-title":"Neurology"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/archopht.1974.01010010097001","article-title":"Insidious atrophy of retinal nerve fibers in multiple sclerosis. 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