{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:52:13Z","timestamp":1774943533871,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To identify risk factors for contact lens\u2010related corneal inflammatory events and mechanical events in wearers of silicone hydrogel lenses on a 30\u2010night extended wear (EW) schedule in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>An interventional study with 188 subjects wearing silicone hydrogel lenses bilaterally on a 30\u2010night EW schedule. Subjects were dispensed with lenses and reviewed at scheduled visits up to 6 months of EW. Multivariate logistic regression, after adjusting for within subject correlation, was used to develop the statistical model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Occupations in non\u2010ideal environments were found to predispose a lens wearer to inflammatory events (p = 0.003). Wearers in the non\u2010ideal group, who had varying degrees of exposure to ocular irritants in their work environment had highest incidence of inflammatory events (19.2%). Wearers in a controlled, ideal environment had lowest levels of events (3.3%). Students occupied a position between the two groups (9.3%). Inflammatory rate was higher among wearers with increased microbial contamination of lenses (p = 0.002). Wearers with an inflammatory event had mean colony forming unit of 1.97 log compared with mean colony forming unit of 1.45 log in group with no inflammatory event. Corneal vascularization was associated with the development of inflammatory events (p = 0.001) with 50% of wearers with vascularization experiencing events compared with 7.6% of subjects with no vascularization. Reduced lens movement was associated with inflammatory events with subjects more likely to develop inflammatory events compared with those wearers with optimal lens movement (p = 0.027).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>A multitude of factors, including environmental influences, lens contamination, ocular characteristics, and lens fit, contributes to the development of inflammatory events, information that is of clinical relevance to practitioners worldwide. Occupational environment was also a contributory factor, confirming that a duty of clinicians is to ascertain the nature of the work environment of lens wearers (and potential wearers) and to balance the needs of the wearer with the potential risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181f6f97d","type":"journal-article","created":{"date-parts":[[2010,9,10]],"date-time":"2010-09-10T06:30:51Z","timestamp":1284100251000},"page":"847-853","source":"Crossref","is-referenced-by-count":28,"title":["Risk Factors for Corneal Inflammatory and Mechanical Events with Extended Wear Silicone Hydrogel Contact Lenses"],"prefix":"10.1002","volume":"87","author":[{"given":"Jerome","family":"Ozkan","sequence":"first","affiliation":[{"name":"Brien Holden Vision Institute New South Wales Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeji","family":"Mandathara","sequence":"additional","affiliation":[{"name":"L V Prasad Eye Institute Hyderabad Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravin","family":"Krishna","sequence":"additional","affiliation":[{"name":"L V Prasad Eye Institute Hyderabad Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padmaja","family":"Sankaridurg","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute New South Wales Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Naduvilath","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute New South Wales Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D. P.","family":"Willcox","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute New South Wales Queensland Australia"},{"name":"School of Optometry and Vision Science University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brien","family":"Holden","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute New South Wales Queensland Australia"},{"name":"School of Optometry and Vision Science University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1097\/00140068-200301001-00042","article-title":"Risk factors for corneal infiltrative events with 30\u2010night continuous wear of silicone hydrogel lenses","volume":"29","author":"McNally 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