{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:08:56Z","timestamp":1778843336781,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To introduce a novel biomarker for screening of primary open\u2010angle glaucoma (POAG) by detecting and measuring brain\u2010derived neurotrophic factor (BDNF) in the serum of normal subjects and patients with early stage of glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Twenty\u2010five glaucoma patients as the case group and 25 age\u2010 and sex\u2010matched normal persons as the control group were tested. The control group comprised 19 men and 6 women, with the mean age of 59.32 \u00b1 11.8 years and without any apparent ocular or systemic diseases. The case group comprised 20 men and 5 women, with the mean age of 59.64 \u00b1 11.56 years, who were assessed by routinely performed clinical and paraclinical investigations. BDNF levels in serum were determined by enzyme\u2010linked immunosorbent assay using monoclonal antibodies specific for BDNF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>The mean of BDNF levels in the serum was 27.16 \u00b1 5.53 ng\/mL in the control subjects and 18.42 \u00b1 4.05 ng\/mL in the subjects with the early stage glaucoma. A statistically significant difference was evident between the two groups (p &lt; 0.05). We found no significant differences in serum BDNF levels according to the subjects' age, gender, duration of the glaucoma, mean intraocular pressure, and blood pressure (p &gt; 0.05). Glaucoma patients who had lower serum BDNF concentration had disclosed a significant negative correlation with pattern standard deviations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>We conclude that BDNF in the serum might be a useful biochemical marker for early detection of POAG. We also propose that this might be a reliable, time efficient, and cost\u2010effective method for diagnosis, screening, and assessing the progression of POAG. However, more studies and trials are needed to investigate these factors in greater detail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3181fc329f","type":"journal-article","created":{"date-parts":[[2010,11,13]],"date-time":"2010-11-13T04:17:17Z","timestamp":1289621837000},"page":"80-85","source":"Crossref","is-referenced-by-count":55,"title":["Brain\u2010Derived Neurotrophic Factor as a Biomarker in Primary Open\u2010Angle Glaucoma"],"prefix":"10.1002","volume":"88","author":[{"given":"Alireza","family":"Ghaffariyeh","sequence":"first","affiliation":[{"name":"Ophthalmology department Dr. Khodadoust Eye Hospital Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazafarin","family":"Honarpisheh","sequence":"additional","affiliation":[{"name":"Ophthalmology department Dr. Khodadoust Eye Hospital Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hossein","family":"Heidari","sequence":"additional","affiliation":[{"name":"Proteomics Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadollah","family":"Puyan","sequence":"additional","affiliation":[{"name":"Ophthalmology department Dr. Khodadoust Eye Hospital Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuad","family":"Abasov","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Z. 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