{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:04:18Z","timestamp":1781571858466,"version":"3.54.5"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To explore non\u2010invasive, protein\u2010based, membrane array technology as a means to evaluate the global immune and angiogenic profile of tear proteins in patients with active ocular cicatricial pemphigoid (OCP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Forty\u2010three proteins consisting of cytokines, angiogenic\/growth factors, and immunoinflammatory modulators were measured by membrane array in tear samples of four control patients and four OCP patients during active disease and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Signals for several distinct and consistent molecular entities were upregulated in all four active OCP tear samples relative to controls. In particular, interleukin\u20108 and matrix metalloproteinase\u20109 were elevated during active disease and decreased after systemic immunomodulatory therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Protein array analysis may provide a well\u2010tolerated assay to monitor levels of inflammatory markers in the tears of OCP patients in response to therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e31821ddc6c","type":"journal-article","created":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T04:41:10Z","timestamp":1304656870000},"page":"1005-1009","source":"Crossref","is-referenced-by-count":27,"title":["Membrane Array Analysis of Tear Proteins in Ocular Cicatricial Pemphigoid"],"prefix":"10.1002","volume":"88","author":[{"given":"Matilda F.","family":"Chan","sequence":"first","affiliation":[{"name":"Francis I. Proctor Research Foundation University of California San Francisco Medical School San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sack","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Research Foundation University of California San Francisco Medical School San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Quigley","sequence":"additional","affiliation":[{"name":"Cancer Research Institute University of California San Francisco Medical School San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Sathe","sequence":"additional","affiliation":[{"name":"State University of New York, SUNY College of Optometry New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinka","family":"Vijmasi","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Research Foundation University of California San Francisco Medical School San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Li","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Research Foundation University of California San Francisco Medical School San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Holsclaw","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Research Foundation University of California San Francisco Medical School San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich C.","family":"Strauss","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Research Foundation University of California San Francisco Medical School San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Research Foundation University of California San Francisco Medical School San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00130832-200410000-00017","article-title":"Ocular cicatricial pemphigoid review","volume":"4","author":"Foster CS","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1167\/iovs.04-0760","article-title":"Membrane array characterization of 80 chemokines, cytokines, and growth factors in open\u2010 and closed\u2010eye tears: angiogenin and other defense system constituents","volume":"46","author":"Sack RA","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_4_2","unstructured":"Team RDC.R: A Language and Environment for Statistical Computing. Available at:http:\/\/www.R\u2010project.org. Accessed March 30 2011."},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10384-005-0319-4","article-title":"Antibody array\u2010generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis","volume":"50","author":"Shoji J","year":"2006","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s10384-007-0461-2","article-title":"Concentration of soluble interleukin\u20106 receptors in tears of allergic conjunctival disease patients","volume":"51","author":"Shoji J","year":"2007","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/OPX.0b013e3181824e20","article-title":"Antibody protein array analysis of the tear film cytokines","volume":"85","author":"Li S","year":"2008","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1398-9995.2008.01858.x","article-title":"Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients","volume":"64","author":"Leonardi A","year":"2009","journal-title":"Allergy"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.exer.2007.07.004","article-title":"Antibody array characterization of inflammatory mediators in allergic and normal tears in the open and closed eye environments","volume":"85","author":"Sack R","year":"2007","journal-title":"Exp Eye Res"}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e31821ddc6c","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0b013e31821ddc6c","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e31821ddc6c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:17:12Z","timestamp":1774937832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0b013e31821ddc6c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1097\/OPX.0b013e31821ddc6c"],"URL":"https:\/\/doi.org\/10.1097\/opx.0b013e31821ddc6c","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}