{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:01:06Z","timestamp":1774944066591,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR\u201096\u2010120"],"award-info":[{"award-number":["DMR\u201096\u2010120"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR\u201098\u2010077"],"award-info":[{"award-number":["DMR\u201098\u2010077"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>It is expected that spectral\u2010domain optical coherence tomography (SD\u2010OCT) will replace time\u2010domain (TD)\u2010OCT in the near future. In this study, we applied a robust set of statistical analyses to evaluate the correlation between retinal nerve fiber layer (RNFL) thickness measurements obtained by SD\u2010OCT and those obtained by TD\u2010OCT in a Chinese population with different stages of glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A total of 40 patients with primary open\u2010angle glaucoma, 31 with primary angle\u2010closure glaucoma (PACG), 31 with suspected glaucoma (GS), 25 with ocular hypertension (OH), and 52 normal subjects were enrolled in this prospective, cross\u2010sectional study. Eyes of all participants were imaged by a single trained operator using the Stratus TD\u2010OCT (fast RNFL scan mode) system and the Cirrus SD\u2010OCT (optic disc cube mode) system during the same visit. The correlations between RNFL thickness measurements obtained from the two OCT instruments were assessed using Pearson correlation analysis and generalized estimating equation (GEE), mixed effect, linear regression models, after adjusting for the effect of individual variation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>There was good correlation in RNFL thickness parameters between the two OCT devices, particularly in average RNFL thickness (Pearson Correlation, 0.8798 vs. GEE mixed model, 0.9470). The proposed GEE mixed model method showed better correlation than the Pearson correlation analysis in each RNFL thickness parameter between the two OCT measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Although the RNFL thickness measurements obtained by the TD\u2010OCT system correlated well with those obtained by the SD\u2010OCT system, clinicians should be cautious when interpreting RNFL thickness data for any subject undergoing longitudinal follow\u2010up with different OCTs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e31822f4b82","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T14:22:38Z","timestamp":1317738158000},"page":"1326-1332","source":"Crossref","is-referenced-by-count":6,"title":["Correlation in Retinal Nerve Fiber Layer Thickness between Two OCT Units"],"prefix":"10.1002","volume":"88","author":[{"given":"Hsin\u2010Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Science China Medical University Taichung Taiwan"},{"name":"Glaucoma Service Department of Ophthalmology China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Cune","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Mathematics Tamkang University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien\u2010Yuan","family":"Lane","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science China Medical University Taichung Taiwan"},{"name":"Department of Psychiatry China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"120","article-title":"Retinal nerve fiber layer analysis in the diagnosis of glaucoma","volume":"17","author":"Zangwill LM","year":"2006","journal-title":"Curr Opin Ophthalmol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1167\/iovs.05-0069","article-title":"Development and comparison of automated classifiers for glaucoma diagnosis using Stratus optical coherence tomography","volume":"46","author":"Huang ML","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s00417-005-1140-y","article-title":"Discrimination between normal and glaucomatous eyes using Stratus optical coherence tomography in Taiwan Chinese subjects","volume":"243","author":"Chen HY","year":"2005","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1167\/iovs.05-0366","article-title":"Optical coherence tomography machine learning classifiers for glaucoma detection: a preliminary study","volume":"46","author":"Burgansky\u2010Eliash Z","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ophtha.2004.10.020","article-title":"Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study","volume":"112","author":"Leung CK","year":"2005","journal-title":"Ophthalmology"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ajo.2006.05.004","article-title":"Baseline optical coherence tomography predicts the development of glaucomatous change in glaucoma suspects","volume":"142","author":"Lalezary M","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ajo.2005.08.023","article-title":"Comparison of retinal nerve fiber layer thickness and optic disk algorithms with optical coherence tomography to detect glaucoma","volume":"141","author":"Manassakorn A","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ajo.2004.08.069","article-title":"Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography","volume":"139","author":"Medeiros FA","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1016\/j.ophtha.2007.03.005","article-title":"Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma","volume":"114","author":"Parikh RS","year":"2007","journal-title":"Ophthalmology"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/IJG.0b013e31815768c4","article-title":"Detection of early glaucoma with optical coherence tomography (StratusOCT)","volume":"17","author":"Nouri\u2010Mahdavi K","year":"2008","journal-title":"J Glaucoma"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1167\/iovs.06-1407","article-title":"Evaluation of optical coherence tomography and heidelberg retinal tomography parameters in detecting early and moderate glaucoma","volume":"48","author":"Naithani P","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.preteyeres.2006.10.002","article-title":"Recent developments in optical coherence tomography for imaging the retina","volume":"26","author":"Velthoven ME","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1001\/archopht.123.12.1715","article-title":"Spectral domain optical coherence tomography: ultra\u2010high speed, ultra\u2010high resolution ophthalmic imaging","volume":"123","author":"Chen TC","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_6_15_2","volume-title":"Cirrus HD\u2010OCT User Manual. Rev. A","author":"Carl Zeiss Meditec Inc.","year":"2008"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/bjo.2008.150698","article-title":"Agreement between spectral\u2010domain and time\u2010domain OCT for measuring RNFL thickness","volume":"93","author":"Vizzeri G","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1167\/iovs.08-2988","article-title":"Cirrus high\u2010definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis","volume":"51","author":"Moreno\u2010Montanes J","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ophtha.2009.04.013","article-title":"Retinal nerve fiber layer imaging with spectral\u2010domain optical coherence tomography: a variability and diagnostic performance study","volume":"116","author":"Leung CK","year":"2009","journal-title":"Ophthalmology"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.ophtha.2010.01.026","article-title":"Retinal nerve fiber layer imaging with spectral\u2010domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection","volume":"117","author":"Leung CK","year":"2010","journal-title":"Ophthalmology"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.ophtha.2008.12.045","article-title":"Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography","volume":"116","author":"Sung KR","year":"2009","journal-title":"Ophthalmology"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archophthalmol.2010.204","article-title":"Spectral\u2010domain optical coherence tomography for detection of localized retinal nerve fiber layer defects in patients with open\u2010angle glaucoma","volume":"128","author":"Kim NR","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.ophtha.2008.12.032","article-title":"Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography","volume":"116","author":"Knight OJ","year":"2009","journal-title":"Ophthalmology"},{"key":"e_1_2_6_23_2","first-page":"2321","article-title":"Slope of the peripapillary nerve fiber layer surface in glaucoma","volume":"39","author":"Caprioli J","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang KY","year":"1986","journal-title":"Biometrika"},{"key":"e_1_2_6_25_2","volume-title":"Analysis of Longitudinal Data","author":"Diggle PJ","year":"1994"},{"key":"e_1_2_6_26_2","article-title":"RNFL thickness measurements with Cirrus HD\u2010OCT and Stratus OCT","volume":"49","author":"Zangwill LM","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_27_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/IJG.0b013e31815c3aeb","article-title":"Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph","volume":"17","author":"Vizzeri G","year":"2008","journal-title":"J Glaucoma"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00061198-200002000-00011","article-title":"An optical model of the human retinal nerve fiber layer: implications of directional reflectance for variability of clinical measurements","volume":"9","author":"Knighton RW","year":"2000","journal-title":"J Glaucoma"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ophtha.2006.08.046","article-title":"Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT","volume":"114","author":"Budenz DL","year":"2007","journal-title":"Ophthalmology"},{"key":"e_1_2_6_30_2","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1167\/iovs.09-4737","article-title":"Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography","volume":"51","author":"Kang SH","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ajo.2004.03.019","article-title":"Optical coherence tomography (OCT) macular and peripapillary retinal nerve fiber layer measurements and automated visual fields","volume":"138","author":"Wollstein G","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ophtha.2004.09.016","article-title":"Relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertensive patients","volume":"112","author":"Henderson PA","year":"2005","journal-title":"Ophthalmology"}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e31822f4b82","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0b013e31822f4b82","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e31822f4b82","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:30:06Z","timestamp":1774938606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0b013e31822f4b82"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1097\/OPX.0b013e31822f4b82"],"URL":"https:\/\/doi.org\/10.1097\/opx.0b013e31822f4b82","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}