{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:44:45Z","timestamp":1790063085498,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>This case report aims to demonstrate that pregnancy\u2010induced biomechanical corneal changes in combination with risk factors for ectasia can develop into (the exacerbation of) keratoconus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report.<\/jats:title>\n                    <jats:p>We describe two women who were clinically diagnosed with keratoconus after their second pregnancy. Both women were myopic and had a history of allergies and contact lens wear. It is unclear whether these two women had a newly diagnosed keratoconus that developed during pregnancy or had experienced an exacerbation of an unrecognized, subclinical keratoconus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Nowadays, documented progression of keratoconus can be treated by corneal crosslinking to stabilize the weakened cornea. Therefore, it is important to understand the effects of hormonal changes in (keratoconic) eyes during pregnancy and to include topographic imaging in unexplained visual deterioration in young individuals, especially during or after a pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e318238c3f2","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T03:44:32Z","timestamp":1320291872000},"page":"112-116","source":"Crossref","is-referenced-by-count":33,"title":["Two Cases of Keratoconus Diagnosed After Pregnancy"],"prefix":"10.1002","volume":"89","author":[{"given":"Nienke","family":"Soeters","sequence":"first","affiliation":[{"name":"Utrecht Cornea Research Group Department of Ophthalmology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayyirih G.","family":"Tahzib","sequence":"additional","affiliation":[{"name":"Utrecht Cornea Research Group Department of Ophthalmology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bakker","sequence":"additional","affiliation":[{"name":"Utrecht Cornea Research Group Department of Ophthalmology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allegonda","family":"Van der Lelij","sequence":"additional","affiliation":[{"name":"Utrecht Cornea Research Group Department of Ophthalmology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"Rabinowitz YS","year":"1998","journal-title":"Surv 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during pregnancy","volume":"31","author":"Gatzioufas Z","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_4_11_2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/ICO.0b013e3181bd9f2d","article-title":"Pregnancy\u2010triggered iatrogenic (post\u2010laser in situ keratomileusis) corneal ectasia\u2014a case report","volume":"29","author":"Padmanabhan P","year":"2010","journal-title":"Cornea"},{"key":"e_1_2_4_12_2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/ICO.0b013e3182068adc","article-title":"Pregnancy\u2010induced progression of keratoconus","volume":"30","author":"Bilgihan K","year":"2011","journal-title":"Cornea"},{"key":"e_1_2_4_13_2","first-page":"151","article-title":"Dynamic mechanical spectroscopy of the cornea for measurement of its viscoelastic properties in vitro","volume":"4","author":"Soergel F","year":"1995","journal-title":"Ger J 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