{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:00:33Z","timestamp":1774944033032,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To emphasize the importance of neuromyelitis optica (NMO)\u2010immunoglobulin G (IgG) antibodies testing in patients with typical optic neuritis (ON) refractory to steroid treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Two patients were evaluated with ON refractory to steroid therapy and poor visual acuity; they were tested for NMO\u2010IgG antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Brain magnetic resonance imaging was normal in both patients. The serum and cerebrospinal fluid were positive for NMO\u2010IgG antibodies. Magnetic resonance imaging of the cervical and thoracic spine revealed lesions longer than three vertebral segments and the diagnosis of NMO was confirmed. Treatment with plasma exchange and immunosuppressive therapy resulted in marked improvement of visual acuity. This improvement was sustained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>The testing for NMO\u2010IgG antibodies is important for distinguishing ON in NMO from multiple sclerosis in cases of ON refractory to steroid treatment. These cases suggest that testing for NMO\u2010IgG antibodies should be performed in comparative trials on a larger series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e31823ac6a8","type":"journal-article","created":{"date-parts":[[2011,11,19]],"date-time":"2011-11-19T04:20:56Z","timestamp":1321676456000},"page":"234-237","source":"Crossref","is-referenced-by-count":0,"title":["Role of NMO\u2010IgG in Distinguishing the Type of Optic Neuritis"],"prefix":"10.1002","volume":"89","author":[{"given":"Lovro","family":"Boji\u0107","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Clinical Hospital Center Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljko","family":"Kova\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Clinical Hospital Center Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branimir","family":"Cerovski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meri","family":"Matijaca","sequence":"additional","affiliation":[{"name":"Department of Neurology Clinical Hospital Center Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kre\u0161imir","family":"Koli\u0107","sequence":"additional","affiliation":[{"name":"Department of Radiology Clinical Hospital Center Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.autrev.2006.02.008","article-title":"Neuromyelitis optica\u2014Devic's syndrome, update","volume":"5","author":"Mandler RN","year":"2006","journal-title":"Autoimmun Rev"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0140-6736(03)12784-5","article-title":"Neuromyelitis optica: what it is and what it might be","volume":"361","author":"Weinshenker BG","year":"2003","journal-title":"Lancet"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1212\/WNL.53.5.1107","article-title":"The clinical course of neuromyelitis optica (Devic's syndrome)","volume":"53","author":"Wingerchuk DM","year":"1999","journal-title":"Neurology"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00415-006-0116-0","article-title":"A patient with a benign course of neuromyelitis optica (Devic's syndrome) over 12 years: MRI follow up and histological findings","volume":"253","author":"Koller H","year":"2006","journal-title":"J Neurol"},{"issue":"4","key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"S371","DOI":"10.1007\/s10072-004-0344-y","article-title":"MR imaging of Devic's neuromyelitis optica","volume":"25","author":"Filippi M","year":"2004","journal-title":"Neurol Sci"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20050304","article-title":"IgG marker of optic\u2010spinal multiple sclerosis binds to the aquaporin\u20104 water channel","volume":"202","author":"Lennon VA","year":"2005","journal-title":"J Exp Med"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s10072-003-0098-y","article-title":"Neuromyelitis optica: importance of cerebrospinal fluid examination during relapse","volume":"24","author":"Milano E","year":"2003","journal-title":"Neurol Sci"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/archneur.63.3.390","article-title":"Brain abnormalities in neuromyelitis optica","volume":"63","author":"Pittock SJ","year":"2006","journal-title":"Arch Neurol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0002-9394(03)00862-6","article-title":"Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial","volume":"137","author":"Beck RW","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1212\/WNL.0b013e318200d80c","article-title":"Absence of cortical demyelination in neuromyelitis optica","volume":"75","author":"Popescu BF","year":"2010","journal-title":"Neurology"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk DM","year":"2007","journal-title":"Lancet Neurol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clineuro.2005.11.008","article-title":"The differential diagnosis of acute transverse myelitis","volume":"108","author":"Brinar VV","year":"2006","journal-title":"Clin Neurol Neurosurg"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000303817.82134.da","article-title":"NMO\u2010IgG predicts the outcome of recurrent optic neuritis","volume":"70","author":"Matiello M","year":"2008","journal-title":"Neurology"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1212\/01.wnl.0000216139.44259.74","article-title":"Revised diagnostic criteria for neuromyelitis optica","volume":"66","author":"Wingerchuk DM","year":"2006","journal-title":"Neurology"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1212\/01.WNL.0000049912.02954.2C","article-title":"Neuromyelitis optica: clinical predictors of a relapsing course and survival","volume":"60","author":"Wingerchuk DM","year":"2003","journal-title":"Neurology"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00415-004-0271-0","article-title":"Clinical characteristics, course and prognosis of relapsing Devic's Neuromyelitis Optica","volume":"251","author":"Ghezzi A","year":"2004","journal-title":"J Neurol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1212\/WNL.58.1.143","article-title":"Plasma exchange for severe attacks of CNS demyelination: predictors of response","volume":"58","author":"Keegan M","year":"2002","journal-title":"Neurology"},{"key":"e_1_2_5_19_2","first-page":"42","article-title":"Neuromyelitis optica","volume":"13","author":"Wingerchuk DM","year":"2006","journal-title":"Int MS J"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1212\/01.WNL.0000159399.81861.D5","article-title":"An open label study of the effects of rituximab in neuromyelitis optica","volume":"64","author":"Cree BA","year":"2005","journal-title":"Neurology"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1212\/WNL.51.4.1219","article-title":"Devic's neuromyelitis optica: a prospective study of seven patients treated with prednisone and azathioprine","volume":"51","author":"Mandler RN","year":"1998","journal-title":"Neurology"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.clineuro.2005.11.017","article-title":"The spectrum of disseminated encephalomyelitis","volume":"108","author":"Brinar VV","year":"2006","journal-title":"Clin Neurol Neurosurg"},{"key":"e_1_2_5_23_2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1177\/1352458506070756","article-title":"Recurrent optic neuromyelitis with endocrinopathies: a new syndrome or just a coincidence?","volume":"12","author":"Petravi\u0107 D","year":"2006","journal-title":"Mult Scler"}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e31823ac6a8","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0b013e31823ac6a8","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e31823ac6a8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:29:20Z","timestamp":1774938560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0b013e31823ac6a8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1097\/OPX.0b013e31823ac6a8"],"URL":"https:\/\/doi.org\/10.1097\/opx.0b013e31823ac6a8","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}