{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:03:34Z","timestamp":1774944214093,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>Buried disc drusen are an important differential diagnosis for papilledema. Spectral domain optical coherence tomography (SD\u2010OCT) affords clinicians with new non\u2010invasive opportunities to probe below the surface of the optic nerve. Clinicians may use the knowledge of this appearance to rule out buried disc drusen in patients with irregular optic nerve borders or a bulging, hyperemic appearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>SD\u2010OCTs were obtained in a patient with one surfacing disc druse, identifying the nature of the appearance of this disc druse and others in this and the contralateral eye when imaged with this technology. B\u2010scan ultrasonography was used to confirm the presence of disc drusen. Additional scans in multiple patients with confirmed buried drusen were obtained for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Drusen appear as rounded hyporeflectant areas on SD\u2010OCT, similar in appearance to blood vessels. They share the appearance of cysts but show a fine hyperreflective border anteriorly. These same discrete hyporeflective areas were found at various depths within optic nerve heads with confirmed buried disc drusen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>The hyporeflective appearance may not be anticipated by clinicians, as B\u2010scans show calcified drusen as hyperreflective on echo. It is hypothesized that the hyporeflectant appearance of drusen is due to a constancy in refractive index through the druse, as OCT detects changes in optical reflectivity. Thus, drusen are likely dense and homogenous. SD\u2010OCT may be more useful in those patients with buried disc drusen which are not calcified as B\u2010scan often contributes little in such cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e31824ee8e0","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T13:32:42Z","timestamp":1332509562000},"source":"Crossref","is-referenced-by-count":23,"title":["Buried Disc Drusen Have Hypo\u2010Reflective Appearance on SD\u2010OCT"],"prefix":"10.1002","volume":"89","author":[{"given":"Samantha","family":"Slotnick","sequence":"first","affiliation":[{"name":"Department of Clinical Science SUNY Eye Institute SUNY State College of Optometry New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Clinical Science SUNY Eye Institute SUNY State College of Optometry New York New York"},{"name":"Eye Institute and Laser Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s11910-008-0062-6","article-title":"Drusen of the optic disc","volume":"8","author":"Lam BL","year":"2008","journal-title":"Curr Neurol Neurosci Rep"},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/08820530390895244","article-title":"Optic nerve head drusen","volume":"18","author":"Davis PL","year":"2003","journal-title":"Semin Ophthalmol"},{"key":"e_1_2_10_4_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/archophthalmol.2008.524","article-title":"Differentiating optic disc edema from optic nerve head drusen on optical coherence tomography","volume":"127","author":"Johnson LN","year":"2009","journal-title":"Arch 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improvements with spectral domain optical coherence tomography","volume":"18","author":"Yi K","year":"2009","journal-title":"J Glaucoma"},{"key":"e_1_2_10_12_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2342-10-11","article-title":"In\u2010vivo high resolution imaging of optic nerve head drusen using spectral\u2010domain Optical Coherence Tomography","volume":"10","author":"Murthy RK","year":"2010","journal-title":"BMC Med Imaging"},{"key":"e_1_2_10_13_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ophtha.2010.09.006","article-title":"Differentiation of optic nerve head drusen and optic disc edema with spectral\u2010domain optical coherence tomography","volume":"118","author":"Lee KM","year":"2011","journal-title":"Ophthalmology"}],"container-title":["Optometry and Vision 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