{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T21:52:57Z","timestamp":1782597177313,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To report demographics, wearing patterns, and symptoms from soft contact lens (SCL) wearers with significant SCL\u2010related dryness symptoms with and without significant ocular signs of dryness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>In a multicenter, prospective observational clinical trial, symptomatic SCL wearers reported significant SCL\u2010related dryness via self\u2010administered questionnaire of frequency and intensity of dryness after a dry eye (DE) examination. DE etiology was assigned post hoc by an expert panel, and those with and without significant DE\u2010related signs were analyzed by univariate logistic regression. Possible DE etiologies were aqueous tear deficiency, SCL\u2010induced tear instability, meibomian gland dysfunction, or \u201cother.\u201d Wearers without signs that qualified for any DE etiology were designated as No DE Signs (NDES).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Of the 226 SCL symptomatic wearers examined, 23% were without signs, 30% had aqueous tear deficiency, 25% had SCL\u2010induced tear instability, 14% had meibomian gland dysfunction, and 8% had \u201cother\u201d diagnoses. The NDES wearers had significantly longer pre\u2010lens break\u2010up time (9.8 vs. 6.6 s, p &lt; 0.0001), better lens wetting (3.4 vs. 2.4 0 to 4 scale, p &lt; 0.0001), lower levels of film deposits on lenses (0.45 vs. 0.92, 0 to 4 scale, p &lt; 0.0001), and of most slit lamp signs. The NDES wearers were significantly more likely to be male (36% vs.19%, p = 0.013), were less likely to have deteriorating comfort during the day (81% vs. 97%, p = 0.001), reported longer average hours of comfortable wear (11 \u00b1 3 vs. 9 \u00b1 4 h, p = 0.014), had older contact lenses (18 \u00b1 14 vs. 13 \u00b1 12 days, p = 0.029), and greater intensity of photophobia early and late in the day (p = 0.043 and 0.021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Symptoms of dryness in SCL wearers stem from a variety of underlying causes. However, nearly one\u2010quarter of these symptomatic SCL wearers appear to be free of signs of dryness. The effective management of CL\u2010related dryness requires a comprehensive range of clinical assessments and the use of a diverse range of management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e3182640af8","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T15:13:56Z","timestamp":1342797236000},"page":"1125-1132","source":"Crossref","is-referenced-by-count":64,"title":["Soft Contact Lens\u2010Related Dryness with and without Clinical Signs"],"prefix":"10.1002","volume":"89","author":[{"given":"Graeme","family":"Young","sequence":"first","affiliation":[{"name":"Visioncare Research Ltd Farnham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Chalmers","sequence":"additional","affiliation":[{"name":"Clinical Trial Consultant Atlanta 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