{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:51:26Z","timestamp":1775001086655,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Compared with daily disposable wear schedule, continuous wear (CW) or extended wear of contact lenses has been associated with an increased risk of developing an ocular infection. Proof\u2010of\u2010principle studies were conducted to investigate the impact of daily replacement of lenses on the rate of contact lens\u2013related ocular adverse events (AEs) during 30\u2010night CW.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 215 subjects were dispensed with silicone hydrogel lenses on a 30\u2010night CW schedule but replaced lenses daily either each night before sleeping (n = 178 eyes) or each morning after waking (n = 252 eyes). Scheduled clinic visits were conducted at 1 week and 1 month. Neophytes were required to complete 1 week of daily wear before commencing CW. A historical control (n = 191 eyes) using the same site, subject demographics, and visit schedule but monthly lens replacement was used for AE rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Logistic regression analysis showed a significant reduction in mechanical AEs (0.8 vs 5.2%, p = 0.01) and overall AEs (inflammatory and mechanical events) (4.0 vs 8.9%, p = 0.04) when lenses were replaced each morning compared with being replaced monthly. Estimation of handling\u2010related lens contamination of unworn lenses in a subgroup of subjects showed isolation of\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      from the lenses of 35% of subjects, and 65% of subjects had more than 1000 colony\u2010forming units per lens of gram\u2010positive bacterial contamination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Morning lens replacement during CW reduced mechanical and overall ocular AEs. Replacing lenses at night had no beneficial effects perhaps because the benefit of a fresh lens at night might be partially negated by contamination of the contact lens caused by lens handling before overnight eye closure. Contact lens wearers on an extended wear or CW schedule should be advised to minimize lens handling before sleep to reduce the risk of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e31827731ac","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T03:00:10Z","timestamp":1353034810000},"page":"1674-1681","source":"Crossref","is-referenced-by-count":9,"title":["The Effect of Daily Lens Replacement During Overnight Wear on Ocular Adverse Events"],"prefix":"10.1002","volume":"89","author":[{"given":"Jerome","family":"Ozkan","sequence":"first","affiliation":[{"name":"Brien Holden Vision Institute University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.P.","family":"Willcox","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Percy Lazon","family":"de la Jara","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute University of New South Wales Sydney New South Wales Australia"},{"name":"School of Optometry and Vision Science University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeji S.","family":"Mandathara","sequence":"additional","affiliation":[{"name":"L. V. Prasad Eye Institute Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha M.","family":"Rathi","sequence":"additional","affiliation":[{"name":"L. V. Prasad Eye Institute Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varghese","family":"Thomas","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brien A.","family":"Holden","sequence":"additional","affiliation":[{"name":"Brien Holden Vision Institute University of New South Wales Sydney New South Wales Australia"},{"name":"School of Optometry and Vision Science University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1136\/bjo.72.12.926","article-title":"Predisposing factors in microbial keratitis: the significance of contact lens wear","volume":"72","author":"Dart JK","year":"1988","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ophtha.2005.08.013","article-title":"Microbial keratitis predisposing factors and morbidity","volume":"113","author":"Keay L","year":"2006","journal-title":"Ophthalmology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/bjo.87.7.834","article-title":"Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases","volume":"87","author":"Bourcier T","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0140-6736(98)09385-4","article-title":"Incidence of contact lens\u2013associated microbial keratitis and its related morbidity","volume":"354","author":"Cheng KH","year":"1999","journal-title":"Lancet"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/01.ico.0000138844.90668.91","article-title":"Microbial keratitis in prospective studies of extended wear with disposable hydrogel contact lenses","volume":"24","author":"Holden BA","year":"2005","journal-title":"Cornea"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.ophtha.2008.04.002","article-title":"The incidence of contact lens\u2010related microbial keratitis in Australia","volume":"115","author":"Stapleton F","year":"2008","journal-title":"Ophthalmology"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ajo.2007.06.037","article-title":"Relationship between climate, disease severity, and causative organism for contact lens\u2013associated microbial keratitis in Australia","volume":"144","author":"Stapleton F","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/01.ICL.0000141923.63458.DF","article-title":"Microbial changes in conjunctival flora with 30\u2010day continuous wear silicone hydrogel contact lenses","volume":"31","author":"Iskeleli G","year":"2005","journal-title":"Eye Contact Lens"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/OPX.0b013e3181d408ee","article-title":"Pathogenesis of contact lens\u2010associated microbial keratitis","volume":"87","author":"Fleiszig SM","year":"2010","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_11_1","first-page":"250","article-title":"A 3\u2010year prospective study of the clinical performance of daily disposable contact lenses compared with frequent replacement and conventional daily wear contact lenses","volume":"22","author":"Solomon OD","year":"1996","journal-title":"CLAO J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/S1367-0484(11)60051-9","article-title":"Influence of care system and wearing modality on clinical performance of a single silicone hydrogel contact lens","volume":"34","author":"Lazon de la Jara P","year":"2011","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/S0161-6420(03)00795-4","article-title":"Comparison of adverse events with daily disposable hydrogels and spectacle wear: results from a 12\u2010month prospective clinical trial","volume":"110","author":"Sankaridurg PR","year":"2003","journal-title":"Ophthalmology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ajo.2005.08.047","article-title":"Prolonging contact lens wear and making contact lens wear safer","volume":"141","author":"Foulks GN","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2672.1997.tb03598.x","article-title":"Microbial contamination of hydrogel contact lenses","volume":"82","author":"Gopinathan U","year":"1997","journal-title":"J Appl Microbiol"},{"key":"e_1_2_6_16_1","first-page":"30","article-title":"Bacterial populations on 30\u2010night extended wear silicone hydrogel lenses","volume":"27","author":"Keay L","year":"2001","journal-title":"CLAO J"},{"key":"e_1_2_6_17_1","first-page":"100","article-title":"Microbial colonization of soft contact lenses over time","volume":"78","author":"Sweeney DF","year":"2001","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00006324-199303000-00002","article-title":"Microbial contamination of hydrophilic contact lenses: quantitation and identification of microorganisms associated with contact lenses while on the eye","volume":"70","author":"Hart DE","year":"1993","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00003226-199905000-00008","article-title":"Colonization of hydrogel lenses with Streptococcus pneumoniae: risk of development of corneal infiltrates","volume":"18","author":"Sankaridurg PR","year":"1999","journal-title":"Cornea"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0161-6420(87)33513-4","article-title":"Severe corneal infections associated with contact lens wear","volume":"94","author":"Chalupa E","year":"1987","journal-title":"Ophthalmology"},{"key":"e_1_2_6_21_1","first-page":"47","article-title":"Gram\u2010negative bacteria can induce contact lens\u2013related acute red eye (CLARE) responses","volume":"22","author":"Holden BA","year":"1996","journal-title":"CLAO J"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1128\/jcm.34.10.2426-2431.1996","article-title":"Haemophilus influenzae adherent to contact lenses associated with production of acute ocular inflammation","volume":"34","author":"Sankaridurg PR","year":"1996","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00003226-200001000-00023","article-title":"Isolation of Staphylococcus aureus from a contact lens at the time of a contact lens\u2013induced peripheral ulcer: case report","volume":"19","author":"Jalbert I","year":"2000","journal-title":"Cornea"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00417-007-0703-5","article-title":"Bacterial adhesion to conventional hydrogel and new silicone hydrogel contact lens materials","volume":"246","author":"Kodjikian L","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/01.opx.0000168585.53845.64","article-title":"Adhesion of Pseudomonas aeruginosa and Staphylococcus epidermidis to silicone hydrogel contact lenses","volume":"82","author":"Henriques M","year":"2005","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/01.ico.0000230324.28956.77","article-title":"Influence of day and night wear on surface properties of silicone hydrogel contact lenses and bacterial adhesion","volume":"25","author":"Vermeltfoort PB","year":"2006","journal-title":"Cornea"},{"key":"e_1_2_6_27_1","first-page":"240","article-title":"Microbial contamination of hydrophilic contact lenses. Part II: quantitation of microbes after patient handling and after aseptic removal from the eye","volume":"18","author":"Mowrey\u2010McKee MF","year":"1992","journal-title":"CLAO J"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/ICL.0b013e3181d20cae","article-title":"Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review","volume":"36","author":"Szczotka\u2010Flynn LB","year":"2010","journal-title":"Eye Contact Lens"},{"key":"e_1_2_6_29_1","article-title":"Time course of the development of contact lens case and contact lens contamination","volume":"50","author":"Lakkis C","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clae.2006.09.007","article-title":"Clinical and laboratory testing of a silver\u2010impregnated lens case","volume":"29","author":"Amos CF","year":"2006","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1167\/iovs.11-8197","article-title":"In vivo assessment of antimicrobial efficacy of silver\u2010impregnated contact lens storage cases","volume":"53","author":"Dantam J","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_32_1","first-page":"640","article-title":"Antimicrobial efficacy of a silver layer on hydrogel lenses","volume":"97","author":"Nissen S","year":"2000","journal-title":"Ophthalmologe"},{"key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1888-4296(10)70020-0","article-title":"Ability of silver\u2010impregnated contact lenses to control microbial growth and colonisation","volume":"3","author":"Willcox MD","year":"2010","journal-title":"J Optom"},{"key":"e_1_2_6_34_1","article-title":"The effect of silver\u2010infused silicone hydrogel contact lenses on the ocular biota during daily wear","volume":"52","author":"Lakkis C","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_35_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/01.ico.0000224636.57062.90","article-title":"Prevention of bacterial colonization of contact lenses with covalently attached selenium and effects on the rabbit cornea","volume":"25","author":"Mathews SM","year":"2006","journal-title":"Cornea"},{"key":"e_1_2_6_36_1","article-title":"Efficacy and clinical performance of selenium antibacterial silicone hydrogel contact lenses","volume":"50","author":"Ozkan J","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/OPX.0b013e31816bea0f","article-title":"Fimbrolide\u2010coated antimicrobial lenses: their in vitro and in vivo effects","volume":"85","author":"Zhu H","year":"2008","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1111\/j.1365-2672.2008.03942.x","article-title":"A novel cationic\u2010peptide coating for the prevention of microbial colonization on contact lenses","volume":"105","author":"Willcox MD","year":"2008","journal-title":"J Appl Microbiol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1167\/iovs.09-4068","article-title":"In vivo performance of melimine as an antimicrobial coating for contact lenses in models of CLARE and CLPU","volume":"51","author":"Cole N","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_40_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.clae.2008.12.008","article-title":"A comparison of regimen methods for the removal and inactivation of bacteria, fungi and Acanthamoeba from two types of silicone hydrogel lenses","volume":"32","author":"Kilvington S","year":"2009","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_6_41_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/OPX.0b013e31821bf976","article-title":"Importance of rub and rinse in use of multipurpose contact lens solution","volume":"88","author":"Zhu H","year":"2011","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_42_1","first-page":"182","article-title":"Penetration of topical ciprofloxacin by presoaked medicated soft contact lenses","volume":"25","author":"Kalayci D","year":"1999","journal-title":"CLAO J"},{"key":"e_1_2_6_43_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/OPX.0b013e318243280e","article-title":"Effect of prophylactic antibiotic drops on ocular microbiota and physiology during silicone hydrogel lens wear","volume":"89","author":"Ozkan J","year":"2012","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_44_1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/OPX.0b013e3181f6f97d","article-title":"Risk factors for corneal inflammatory and mechanical events with extended wear silicone hydrogel contact lenses","volume":"87","author":"Ozkan J","year":"2010","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_45_1","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1097\/00140068-200301001-00042","article-title":"Risk factors for corneal infiltrative events with 30\u2010night continuous wear of silicone hydrogel lenses","volume":"29","author":"McNally JJ","year":"2003","journal-title":"Eye Contact Lens"},{"key":"e_1_2_6_46_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/1536867X0200200302","article-title":"The robust variance estimator for two\u2010stage models","volume":"2","author":"Hardin JW","year":"2002","journal-title":"Stata J"},{"key":"e_1_2_6_47_1","volume-title":"Intercooled STATA for Windows","author":"STATA Corporation","year":"2009"},{"key":"e_1_2_6_48_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/OPX.0b013e3180485d5f","article-title":"The epidemiology of contact lens related infiltrates","volume":"84","author":"Stapleton F","year":"2007","journal-title":"Optom Vis Sci"},{"key":"e_1_2_6_49_1","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1128\/iai.63.11.4501-4505.1995","article-title":"Changes to the ocular biota with time in extended\u2010 and daily\u2010wear disposable contact lens use","volume":"63","author":"Stapleton F","year":"1995","journal-title":"Infect Immun"},{"key":"e_1_2_6_50_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/ICL.0b013e31820d12db","article-title":"External ocular surface and lens microbiota in contact lens wearers with corneal infiltrates during extended wear of hydrogel lenses","volume":"37","author":"Willcox M","year":"2011","journal-title":"Eye Contact Lens"},{"key":"e_1_2_6_51_1","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1097\/00140068-200301001-00018","article-title":"The causes of and cures for contact lens\u2010induced peripheral ulcer","volume":"29","author":"Wu P","year":"2003","journal-title":"Eye Contact Lens"},{"key":"e_1_2_6_52_1","first-page":"217","volume-title":"Silicone Hydrogels Continuous\u2010Wear Contact Lenses","author":"Sankaridurg P","year":"2004"},{"key":"e_1_2_6_53_1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0161-6420(99)90346-9","article-title":"Adverse events with extended wear of disposable hydrogels: results for the first 13 months of lens wear","volume":"106","author":"Sankaridurg PR","year":"1999","journal-title":"Ophthalmology"},{"key":"e_1_2_6_54_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0161-6420(02)01283-6","article-title":"Trends in contact lens\u2013associated microbial keratitis in Southern India","volume":"110","author":"Sharma S","year":"2003","journal-title":"Ophthalmology"},{"key":"e_1_2_6_55_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4103\/0019-557X.92408","article-title":"A study on prevalence of bacteria in the hands of children and their perception on hand washing in two schools of Bangalore and Kolkata","volume":"55","author":"Ray SK","year":"2011","journal-title":"Indian J Public Health"},{"key":"e_1_2_6_56_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.clae.2011.11.003","article-title":"Hand hygiene prior to contact lens handling is problematical","volume":"35","author":"McMonnies CW","year":"2012","journal-title":"Cont Lens Anterior Eye"},{"key":"e_1_2_6_57_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1444-0938.2002.tb03031.x","article-title":"Bacterial populations on high\u2010Dk silicone hydrogel contact lenses: effect of length of wear in asymptomatic patients","volume":"85","author":"Willcox MD","year":"2002","journal-title":"Clin Exp Optom"},{"key":"e_1_2_6_58_1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1097\/OPX.0b013e3181bbca18","article-title":"Risk factors for contact lens bacterial contamination during continuous wear","volume":"86","author":"Szczotka\u2010Flynn LB","year":"2009","journal-title":"Optom Vis Sci"}],"container-title":["Optometry and Vision Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e31827731ac","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1097\/OPX.0b013e31827731ac","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/OPX.0b013e31827731ac","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:58:59Z","timestamp":1774951139000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/OPX.0b013e31827731ac"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1097\/OPX.0b013e31827731ac"],"URL":"https:\/\/doi.org\/10.1097\/opx.0b013e31827731ac","archive":["Portico"],"relation":{},"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}