{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:19:12Z","timestamp":1774959552651,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Lymphoma is the most common malignancy of the ocular adnexa. Most of the ocular adnexa lymphomas are non\u2010Hodgkin B\u2010cell lymphomas. The most common type of ocular adnexa lymphoma is primary extranodal marginal zone B\u2010cell lymphoma of the MALT (mucosa\u2010associated lymphoid tissue). Most of these neoplasms are primary extranodal lymphomas, although 10% to 32% are secondary tumors from disseminated disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 58\u2010year\u2010old woman presented for a comprehensive examination, with the chief complaint of ocular discomfort in both eyes. Anterior segment examination revealed bilateral salmon\u2010colored lesions of the inferior and superior conjunctivae. The patient was referred for systemic evaluation and histopathology of the conjunctival lesions. She was diagnosed as having marginal zone lymphoma of the MALT and underwent radiation therapy (RT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ocular lymphoma may present on routine examination or with mild symptoms. Although most commonly a primary extranodal neoplasm, the condition may be associated with disseminated lymphoma and requires thorough evaluation and staging of the disease for determination of appropriate treatment. The primary eye care provider plays an important role in the identification and staging of the disease, as well as managing complications from RT. It is also important to recognize that concurrent conditions requiring treatment with topical medications, such as glaucoma, may be complicated after treatment because of the inflammation and ocular surface irritation after RT. The necessity and benefit of the addition of intraocular pressure medications during that time should be measured on a case\u2010by\u2010case basis. Patients should be followed closely after treatment for relapse of disease and identification of complications from ocular RT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e318280050b","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T03:13:25Z","timestamp":1358478805000},"source":"Crossref","is-referenced-by-count":3,"title":["The Diagnosis and Management of Ocular Lymphoma"],"prefix":"10.1002","volume":"90","author":[{"given":"Lori","family":"Vollmer","sequence":"first","affiliation":[{"name":"Nova Southeastern University Fort Lauderdale Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1182\/blood-2008-12-195453","article-title":"Extranodal marginal zone lymphoma of the ocular adnexa","volume":"114","author":"Stefanovic A","year":"2009","journal-title":"Blood"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ijrobp.2011.03.050","article-title":"Localized orbital mucosa\u2010associated lymphoma tissue lymphoma managed with primary radiation therapy: efficacy and toxicity","volume":"81","author":"Goda JS","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_2_7_4_1","first-page":"722","article-title":"Translocation (5;11) in a conjunctival MALT lymphoma","volume":"4","author":"Clement CG","year":"2011","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/bjo.83.6.742","article-title":"Ocular adnexal lymphoma\u2014comparison of MALT lymphoma with other histological types","volume":"83","author":"Cahill M","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.ijrobp.2010.07.1992","article-title":"Treatment effects and sequelae of radiation therapy for orbital mucosa\u2013associated lymphoid tissue lymphoma","volume":"81","author":"Hata M","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00277-004-0914-3","article-title":"Extranodal marginal zone B\u2010cell lymphomas of mucosa\u2010associated lymphoid tissue type of the orbit and ocular adnexa","volume":"84","author":"Lee JL","year":"2005","journal-title":"Ann Hematol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijrobp.2009.04.018","article-title":"Primary radiation therapy in patients with localized orbital marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue (MALT lymphoma)","volume":"77","author":"Son SH","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/annonc\/mdm513","article-title":"Ocular adnexal MALT lymphoma: an intriguing model for antigen\u2010driven lymphomagenesis and microbial\u2010targeted therapy","volume":"19","author":"Ferreri AJ","year":"2008","journal-title":"Ann Oncol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/ICO.0b013e3180307667","article-title":"Asymptomatic conjunctival mucosa\u2010associated lymphoid tissue\u2010type lymphoma with presumed intraocular involvement","volume":"26","author":"Ramulu P","year":"2007","journal-title":"Cornea"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/modpathol.3880366","article-title":"Clinical, histopathological, and immunogenetic analysis of ocular adnexal lymphoproliferative disorders: characterization of malt lymphoma and reactive lymphoid hyperplasia","volume":"14","author":"Mannami T","year":"2001","journal-title":"Mod Pathol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/bjo.85.1.63","article-title":"Long\u2010term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. 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