{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:22:15Z","timestamp":1791436935721,"version":"4.3.3"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OVS"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The common change in corneal morphology that is seen in keratoconus (KC) suggests the presence of common high\u2010order aberration (HOA) structures and the potential for HOA corrections that apply to more than one eye. The purpose of this investigation is to classify a sample of KC eyes into subgroups based on similar HOA characteristics and simulate optical performance of common HOA corrections on members of each subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>High\u2010order aberrations were recorded over a 5\u2010mm pupil on 111 KC eyes. The eyes were divided into five subgroups based on observed commonality in HOA structure. From each subgroup, two eyes were removed for later evaluation of corrections. Principal components analysis was performed on the remaining eyes of each subgroup. The first principal component was scaled to form a set of corrections. Simulated optical correction of the test eyes was performed by identifying the magnitude of the inner\u2010group correction providing the lowest level of residual higher order root mean square wavefront error (HORMS). Residual uncorrected HORMS was compared with levels found in uncorrected normal eyes and KC eyes wearing rigid gas\u2010permeable corrections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety (81%) of the 111 eyes were included in one of the five subgroups. All 10 test eyes experienced a reduction in HORMS with a template correction compared with their uncorrected levels. Median HORMS reduced from uncorrected levels of 2.14 to 0.97 \u03bcm. On average, the 10 subjects experienced a 51% reduction in HORMS (minimum, 16%; maximum, 81%; p &lt; 0.01). When scaled to a 4\u2010mm pupil, five of the 10 eyes experienced residual uncorrected HORMS within limits associated with gas\u2010permeable wear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overlap exists across these templates because of the dominance of vertical coma in the HOA structure. All eyes evaluated received reduced HORMS with a template\u2010based correction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/opx.0b013e318288c2b1","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T13:37:23Z","timestamp":1362145043000},"page":"324-334","source":"Crossref","is-referenced-by-count":13,"title":["Template\u2010Based Correction of High\u2010Order Aberration in Keratoconus"],"prefix":"10.1002","volume":"90","author":[{"given":"Jason D.","family":"Marsack","sequence":"first","affiliation":[{"name":"University of Houston College of Optometry Visual Optics Institute Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos J.","family":"Rozema","sequence":"additional","affiliation":[{"name":"University of Houston College of Optometry Visual Optics Institute Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Koppen","sequence":"additional","affiliation":[{"name":"Antwerp University Hospital Department of Ophthalmology Edegem Belgium"},{"name":"University of Antwerp Faculty of Medicine and Health Sciences Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Jose","family":"Tassignon","sequence":"additional","affiliation":[{"name":"University of Antwerp Faculty of Medicine and Health Sciences Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Applegate","sequence":"additional","affiliation":[{"name":"University of Houston College of Optometry Visual Optics Institute Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/B978-0-323-06387-6.00081-7","volume-title":"Cornea","author":"Feder RS","year":"2011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511609541","volume-title":"The Eye and Visual Optical Instruments","author":"Smith G","year":"1997"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.ophtha.2007.01.008","article-title":"Characterizing the wave aberration in eyes with keratoconus or penetrating keratoplasty using a high\u2010dynamic range wavefront sensor","volume":"114","author":"Pantanelli S","year":"2007","journal-title":"Ophthalmology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1167\/iovs.06-1285","article-title":"Magnitude and orientation of Zernike terms in patients with keratoconus","volume":"48","author":"Kosaki R","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/OPX.0b013e31802e64f0","article-title":"Uncorrected wavefront error and visual performance during RGP wear in keratoconus","volume":"84","author":"Marsack JD","year":"2007","journal-title":"Optom Vis Sci"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.ajo.2007.08.004","article-title":"Effect of higher\u2010order aberrations on visual function in keratoconic eyes with a rigid gas\u2010permeable contact lens","volume":"144","author":"Negishi K","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00003226-199603000-00006","article-title":"Biomicroscopic signs and disease severity in keratoconus. 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