{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:15:48Z","timestamp":1786119348572,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1097\/paf.0b013e3181d3de94","type":"journal-article","created":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T05:35:56Z","timestamp":1268890556000},"page":"193-196","source":"Crossref","is-referenced-by-count":4,"title":["Cause of Death Conundrum With Methadone Use"],"prefix":"10.1097","volume":"32","author":[{"given":"Michael C.","family":"Letsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross E.","family":"Zumwalt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaine E.","family":"Benson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-26-20210126","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00000433-199212000-00017","article-title":"Methadone toxicity causing death in ten subjects starting on a methadone maintenance program.","volume":"13","author":"Drummer","year":"1992","journal-title":"Am J Forensic Med Pathol"},{"key":"R2-26-20210126","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1046\/j.1360-0443.2000.951116475.x","article-title":"Lethal methadone intoxications in Geneva, Switzerland, from 1994 to 1998.","volume":"95","author":"Perret","year":"2000","journal-title":"Addiction"},{"key":"R3-26-20210126","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF01225230","article-title":"Methadone and drug addicts.","volume":"106","author":"Worm","year":"1993","journal-title":"Int J Leg Med"},{"key":"R4-26-20210126","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/cc5150","article-title":"Case report: quantification of methadone-induced respiratory depression using toxicokinetic\/toxicodynamic relationships.","volume":"11","author":"Megarbane","year":"2007","journal-title":"Crit Care"},{"key":"R5-26-20210126","first-page":"253","article-title":"Update of the clinical issues regarding methadone (Dolophine) therapy in pain management.","volume":"19","author":"Linderbeck","year":"2008","journal-title":"AACN Adv Crit Care"},{"key":"R6-26-20210126","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/hup.630","article-title":"The effects of methadone and its role in fatalities.","volume":"19","author":"Corkery","year":"2004","journal-title":"Hum Psychopharmacol Clin Exp"},{"key":"R7-26-20210126","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00007691-199606000-00001","article-title":"Stereoselective pharmacokinetics of methadone in chronic pain patients.","volume":"18","author":"Kristensen","year":"1996","journal-title":"Ther Drug Mon"},{"key":"R8-26-20210126","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1067\/mcp.2001.116793","article-title":"Pharmacokinetics and pharmacodynamics of methadone enantiomers after a single oral dose of racemate.","volume":"40","author":"Boulton","year":"2001","journal-title":"Clin Pharmacol Ther"},{"key":"R9-26-20210126","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00004714-200104000-00016","article-title":"Cytochrome P450 2D6 genotype and methadone steady-state concentrations.","volume":"21","author":"Eap","year":"2001","journal-title":"J Clin Psychopharmacol"},{"key":"R10-26-20210126","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2165\/00003088-200241140-00003","article-title":"Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence.","volume":"41","author":"Eap","year":"2002","journal-title":"Clin Pharmacokinet"},{"key":"R12-26-20210126","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.drugalcdep.2006.12.018","article-title":"Association of CYP2D6 ultrarapid metabolizer genotype with deficient patient satisfaction regarding methadone maintenance treatment.","volume":"89","author":"Perez de los Cobos","year":"2007","journal-title":"Drug Alcohol Depend"},{"key":"R13-26-20210126","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cpt1975182180","article-title":"Methadone in man: pharmacokinetic and excretion studies in acute and chronic treatment.","volume":"18","author":"Verebely","year":"1975","journal-title":"Clin Pharmacol Ther"},{"key":"R14-26-20210126","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1067\/mcp.2002.128386","article-title":"Disposition of nasal, intravenous, and oral methadone in healthy volunteers.","volume":"72","author":"Dale","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"R15-26-20210126","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/ewjm.172.1.11","article-title":"Toxicology and pathology of deaths related to methadone: retrospective review.","volume":"172","author":"Karch","year":"2000","journal-title":"West J Med"},{"key":"R16-26-20210126","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/cpt197213164","article-title":"Urinary excretion of methadone in man.","volume":"13","author":"Baselt","year":"1972","journal-title":"Clin Pharmacol Ther"},{"key":"R17-26-20210126","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cpt197722192","article-title":"Methadone maintenance: effect of urinary pH on renal clearance in chronic high and low doses.","volume":"22","author":"Bellward","year":"1977","journal-title":"Clin Pharmacol Ther"},{"key":"R18-26-20210126","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00007691-200208000-00001","article-title":"Characterization of methadone overdose: clinical considerations and the scientific evidence.","volume":"24","author":"Wolff","year":"2002","journal-title":"Ther Drug Monit"},{"key":"R19-26-20210126","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/0959523021000023171","article-title":"Methadone dose and post-mortem blood concentration.","volume":"21","author":"Caplehorn","year":"2002","journal-title":"Drug Alcohol Rev"},{"key":"R20-26-20210126","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jpainsymman.2004.06.012","article-title":"Measurement of QTc in patients receiving chronic methadone therapy.","volume":"29","author":"Cruciani","year":"2005","journal-title":"J Pain Symptom Manage"},{"key":"R21-26-20210126","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1360-0443.2006.01668.x","article-title":"Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients: a cross-sectional study.","volume":"102","author":"Peles","year":"2007","journal-title":"Addiction"},{"key":"R22-26-20210126","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/clinchem\/37.9.1651","article-title":"High-dose methadone and the need for drug measurements in plasma.","volume":"37","author":"Wolff","year":"1991","journal-title":"Clin Chem"},{"key":"R23-26-20210126","doi-asserted-by":"crossref","first-page":"501","DOI":"10.7326\/0003-4819-137-6-200209170-00010","article-title":"Torsade de Pointes associated with very-high-dose methadone.","volume":"137","author":"Krantz","year":"2002","journal-title":"Ann Intern Med"},{"key":"R24-26-20210126","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1520\/JFS2002424","article-title":"Methadone-related deaths in Hennepin County, Minnesota: 1992-2002.","volume":"48","author":"Gagajewski","year":"2003","journal-title":"J Forensic Sci"},{"key":"R26-26-20210126","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/jat\/32.2.165","article-title":"A comparison of methadone, oxycodone, and hydrocodone related deaths in Northeast Ohio.","volume":"32","author":"Baker","year":"2008","journal-title":"J Anal Toxicol"},{"key":"R28-26-20210126","first-page":"675","article-title":"QuickStats: age-adjusted death rates per 100,000 population for the three leading causes of injury death-United States, 1979-2006.","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"}],"container-title":["American Journal of Forensic Medicine &amp; Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/PAF.0b013e3181d3de94","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:20:14Z","timestamp":1786040414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000433-201106000-00026"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/paf.0b013e3181d3de94","relation":{},"ISSN":["0195-7910"],"issn-type":[{"value":"0195-7910","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}