{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:10:50Z","timestamp":1786119050619,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1097\/pai.0b013e3181788186","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T03:23:02Z","timestamp":1229484182000},"page":"47-50","source":"Crossref","is-referenced-by-count":29,"title":["Skin Homing of Treponema pallidum in Early Syphilis"],"prefix":"10.1097","volume":"17","author":[{"given":"Pascale","family":"Quatresooz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rald E.","family":"Pi\u00e9rard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210126","doi-asserted-by":"crossref","first-page":"94","DOI":"10.7326\/0003-4819-121-2-199407150-00003","article-title":"Altered clinical presentation of early syphilis in patients with HIV infection","volume":"121","author":"Hutchinson","year":"1994","journal-title":"Ann Intern Med"},{"key":"R2-8-20210126","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00126334-200312010-00014","article-title":"The recent increase of syphilis cases in Lyon University hospitals is mainly observed in HIV-infected patients: descriptive data from a laboratory-based surveillance system","volume":"34","author":"Giard","year":"2003","journal-title":"J Acquir Immun Defic Syndr"},{"key":"R3-8-20210126","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/sti.2004.009571","article-title":"Recent trends in HIV and other STIs in the United Kingdom: data to the end of 2002","volume":"80","author":"Brown","year":"2004","journal-title":"Sex Transm Infect"},{"key":"R4-8-20210126","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature03072","article-title":"Host immunity and synchronized epidemics of syphilis across the United States","volume":"433","author":"Grassly","year":"2005","journal-title":"Nature"},{"key":"R5-8-20210126","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00000372-198302000-00004","article-title":"Secondary syphilis: clinical morphology and histopathology","volume":"5","author":"Alessi","year":"1983","journal-title":"Am J Dermatopathol"},{"key":"R6-8-20210126","first-page":"399","article-title":"Secondary syphilis. A clinicopathologic study","volume":"10","author":"Jordaan","year":"1988","journal-title":"Am J Dermatopathol"},{"key":"R7-8-20210126","first-page":"102","article-title":"The localization of treponemes and characterization of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious jaws","volume":"69","author":"Engelkens","year":"1993","journal-title":"Genitourin Med"},{"key":"R8-8-20210126","first-page":"135","article-title":"Immunoperoxidase localization of Treponema pallidum: its use in formaldehyde-fixed and paraffin embedded tissue sections","volume":"103","author":"Beckett","year":"1979","journal-title":"Arch Pathol Lab Med"},{"key":"R9-8-20210126","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3349\/ymj.1991.32.4.335","article-title":"Detection of Treponema pallidum in tissue: a comparative study of the avidin-biotin-peroxidase complex, indirect immunoperoxidase, FTA-ABS complement techniques and darkfield method","volume":"32","author":"Lee","year":"1991","journal-title":"Yonsei Med J"},{"key":"R10-8-20210126","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.1365-4362.2000.00029.x","article-title":"Immunoperoxidase technique for detecting spirochetes in tissue sections: comparison with other methods","volume":"39","author":"Phelps","year":"2000","journal-title":"Int J Dermatol"},{"key":"R11-8-20210126","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.0303-6987.2004.00236.x","article-title":"Secondary syphilis: a histologic and immunohistochemical evaluation","volume":"31","author":"Hoang","year":"2004","journal-title":"J Cutan Pathol"},{"key":"R12-8-20210126","first-page":"6","article-title":"La syphilis, la grande simulatrice d\u00e9masqu\u00e9e","volume":"104","author":"Quatresooz","year":"2007","journal-title":"Dermatol Actual"},{"key":"R13-8-20210126","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00007435-200305000-00008","article-title":"AIDS mortality may have contributed to the decline in syphilis rates in the United States in the 1990s","volume":"30","author":"Chesson","year":"2003","journal-title":"Sex Transm Dis"},{"key":"R14-8-20210126","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/sti.77.5.319","article-title":"Surfing with spirochetes: an ongoing syphilis outbreak in Brighton","volume":"77","author":"Poulton","year":"2001","journal-title":"Sex Transm Infect"},{"key":"R15-8-20210126","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/sti.2004.009415","article-title":"Recent trends in the epidemiology of sexually transmitted infections in the European Union","volume":"80","author":"Fenton","year":"2004","journal-title":"Sex Transm Infect"},{"key":"R16-8-20210126","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/bmj.329.7460.249-a","article-title":"Sexually transmitted diseases continue to rise","volume":"329","author":"White","year":"2004","journal-title":"Br Med J"},{"key":"R17-8-20210126","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000082569","article-title":"Sexually transmitted infections in Switzerland: return of the classics","volume":"210","author":"Lautenschlager","year":"2005","journal-title":"Dermatology"},{"key":"R18-8-20210126","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/01.olq.0000180455.79024.e9","article-title":"The changing epidemiology of syphilis","volume":"32","author":"Peterman","year":"2005","journal-title":"Sex Transm Dis"},{"key":"R19-8-20210126","first-page":"426","article-title":"Syphilis: une MST de retour en nos murs","volume":"59","author":"Flagothier","year":"2004","journal-title":"Rev Med Li\u00e9ge"},{"key":"R20-8-20210126","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1136\/bmj.39042.491400.DB","article-title":"Incidence of syphilis in UK rises as HIV diagnoses hold steady","volume":"333","author":"Frauenfelder","year":"2006","journal-title":"Br Med J"},{"key":"R21-8-20210126","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000089021","article-title":"Increased incidence of sexually transmitted infections in Geneva, Switzerland","volume":"212","author":"Abraham","year":"2006","journal-title":"Dermatology"},{"key":"R22-8-20210126","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/01.olq.0000233709.93891.e5","article-title":"Rising rates of syphilis in the era of syphilis elimination","volume":"34","author":"Kerani","year":"2007","journal-title":"Sex Transm Dis"},{"key":"R23-8-20210126","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1468-3083.2004.00859.x","article-title":"Secondary syphilis presenting as a lichen planus-like rash","volume":"18","author":"Tang","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R24-8-20210126","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2165\/00128071-200607050-00003","article-title":"Cutaneous manifestations of syphilis. Recognition and management","volume":"7","author":"Lautenschlager","year":"2006","journal-title":"Am J Clin Dermatol"},{"key":"R25-8-20210126","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000090663","article-title":"Presternal indurated ulceration: primary syphilis","volume":"212","author":"Lautenschlager","year":"2006","journal-title":"Dermatology"},{"key":"R26-8-20210126","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/j.1365-4632.2006.02869.x","article-title":"Evaluation of specific antibodies for early diagnosis and management of syphilis","volume":"45","author":"Dang","year":"2006","journal-title":"Int J Dermatol"},{"key":"R27-8-20210126","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1128\/JCM.01578-06","article-title":"Development of a real-time PCR assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testing","volume":"45","author":"Leslie","year":"2007","journal-title":"J Clin Microbiol"},{"key":"R28-8-20210126","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00007435-199609000-00004","article-title":"Comparison of methods for the detection of Treponema pallidum in lesions of early syphilis","volume":"23","author":"Cummings","year":"1996","journal-title":"Sex Transm Dis"},{"key":"R29-8-20210126","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0732-8893(00)00213-3","article-title":"Treponema pallidum western blot: comparison with the FTA-ABS test as a confirmatory test for syphilis","volume":"39","author":"Backhouse","year":"2001","journal-title":"Diag Microbiol Inf Dis"},{"key":"R30-8-20210126","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1136\/sti.79.6.479","article-title":"Use of PCR in the diagnosis of early syphilis in the United Kingdom","volume":"79","author":"Palmer","year":"2003","journal-title":"Sex Transm Infect"},{"key":"R31-8-20210126","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000076479","article-title":"Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate","volume":"208","author":"Wenhai","year":"2004","journal-title":"Dermatology"},{"key":"R32-8-20210126","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1111\/j.1469-0691.2006.01566.x","article-title":"Specific and sensitive diagnosis of syphilis using a real-time PCR for Treponema pallidum","volume":"12","author":"Koek","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"R33-8-20210126","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1574-695X.2006.00191.x","article-title":"Molecular methods used in clinical laboratory: prospects and pitfalls","volume":"49","author":"Morshed","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"R34-8-20210126","first-page":"277","article-title":"Identification immunohistochimique des spiroch\u00e8tes de type Borrelia","volume":"118","author":"Arrese Estrada","year":"1991","journal-title":"Ann Dermatol Venereol"}],"container-title":["Applied Immunohistochemistry & Molecular Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/PAI.0b013e3181788186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:27:08Z","timestamp":1786037228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00129039-200901000-00008"}},"subtitle":["An Immunohistochemical Study"],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/pai.0b013e3181788186","relation":{},"ISSN":["1541-2016"],"issn-type":[{"value":"1541-2016","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}