{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:04Z","timestamp":1786119424778,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1097\/pai.0b013e3181bbd5d5","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T02:26:34Z","timestamp":1266373594000},"page":"119-127","source":"Crossref","is-referenced-by-count":3,"title":["Most Morphologic Features in Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (CLL\/SLL) do not Reliably Predict Underlying FISH Genetics or Immunoglobulin Heavy Chain Variable Region Somatic Mutational Status"],"prefix":"10.1097","volume":"18","author":[{"given":"Christine F.","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin E.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huining","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Babb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Vasef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaaren K.","family":"Reichard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210126","article-title":"Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma. 4th ed","author":"Muller-Hermelink","year":"2008"},{"key":"R2-4-20210126","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"R3-4-20210126","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"key":"R4-4-20210126","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.194.11.1625","article-title":"Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells","volume":"194","author":"Klein","year":"2001","journal-title":"J Exp Med"},{"key":"R5-4-20210126","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","article-title":"Genomic aberrations and survival in chronic lymphocytic leukemia","volume":"343","author":"Dohner","year":"2000","journal-title":"N Engl J Med"},{"key":"R6-4-20210126","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1309\/H9AREV6E2JTMEC6J","article-title":"Cytogenetic abnormalities detected by fluorescence in situ hybridization on paraffin-embedded chronic lymphocytic leukemia\/small lymphocytic lymphoma lymphoid tissue biopsy specimens","volume":"130","author":"Flanagan","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"R7-4-20210126","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1182\/blood.V100.4.1410.h81602001410_1410_1416","article-title":"V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia","volume":"100","author":"Krober","year":"2002","journal-title":"Blood"},{"key":"R9-4-20210126","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJMoa023143","article-title":"ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia","volume":"348","author":"Crespo","year":"2003","journal-title":"N Engl J Med"},{"key":"R10-4-20210126","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1309\/230199FLE32ATUB0","article-title":"Comparative analysis of flow cytometric techniques in assessment of ZAP-70 expression in relation to IgVH mutational status in chronic lymphocytic leukemia","volume":"127","author":"Chen","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"R11-4-20210126","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1080\/10428190802360810","article-title":"Combinations of ZAP-70, CD38 and IGHV mutational status as predictors of time to first treatment in CLL","volume":"49","author":"Morilla","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"R12-4-20210126","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1056\/NEJMoa040857","article-title":"ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia","volume":"351","author":"Rassenti","year":"2004","journal-title":"N Engl J Med"},{"key":"R13-4-20210126","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/01.pai.0000213152.41440.34","article-title":"ZAP70 expression assessed by immunohistochemistry on peripheral blood: a simple prognostic assay for patients with chronic lymphocytic leukemia","volume":"15","author":"Roullet","year":"2007","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"R14-4-20210126","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/10428190500272846","article-title":"ZAP-70 immunoreactivity is a prognostic marker of disease progression in chronic lymphocytic leukemia","volume":"47","author":"Vener","year":"2006","journal-title":"Leuk Lymphoma"},{"key":"R15-4-20210126","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/sj.leu.2404458","article-title":"ZAP-70 expression, as detected by immunohistochemistry on bone marrow biopsies from early-phase CLL patients, is a strong adverse prognostic factor","volume":"21","author":"Zanotti","year":"2007","journal-title":"Leukemia"},{"key":"R16-4-20210126","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1309\/7Q1J-1AA8-DU4Q-PVLQ","article-title":"Typical and atypical chronic lymphocytic leukemia differ clinically and immunophenotypically","volume":"116","author":"Frater","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"R17-4-20210126","first-page":"219","article-title":"Prognostic relevance of the FAB morphological criteria in chronic lymphocytic leukemia: correlations with IgVH gene mutational status and other prognostic markers","volume":"53","author":"Schwarz","year":"2006","journal-title":"Neoplasma"},{"key":"R18-4-20210126","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1182\/blood-2002-10-3306","article-title":"ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile","volume":"101","author":"Wiestner","year":"2003","journal-title":"Blood"},{"key":"R19-4-20210126","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/modpathol.3800630","article-title":"Automated analysis of fluorescence in situ hybridization on fixed, paraffin-embedded whole tissue sections in B-cell lymphoma","volume":"19","author":"Reichard","year":"2006","journal-title":"Mod Pathol"},{"key":"R20-4-20210126","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1182\/blood.V87.12.5242.bloodjournal87125242","article-title":"Analysis of clonal rearrangements of the Ig heavy chain locus in acute leukemia","volume":"87","author":"Height","year":"1996","journal-title":"Blood"},{"key":"R21-4-20210126","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/modpathol.3800677","article-title":"Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome","volume":"19","author":"Lai","year":"2006","journal-title":"Mod Pathol"},{"key":"R22-4-20210126","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/jcp.49.8.672","article-title":"Assessment of IgH PCR strategies in multiple myeloma","volume":"49","author":"Owen","year":"1996","journal-title":"J Clin Pathol"},{"key":"R23-4-20210126","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"R25-4-20210126","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2141.2007.06928.x","article-title":"Determination of how many immunoglobulin variable region heavy chain mutations are allowable in unmutated chronic lymphocytic leukaemia-long-term follow up of patients with different percentages of mutations","volume":"140","author":"Hamblin","year":"2008","journal-title":"Br J Haematol"},{"key":"R26-4-20210126","first-page":"284","article-title":"CLL biology and prognosis.","volume":"278-","author":"Dighiero","year":"2005","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"R27-4-20210126","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1182\/blood-2005-04-1677","article-title":"Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia","volume":"107","author":"Binet","year":"2006","journal-title":"Blood"},{"key":"R28-4-20210126","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1200\/JCO.2007.15.4393","article-title":"Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?","volume":"26","author":"Caligaris-Cappio","year":"2008","journal-title":"J Clin Oncol"},{"key":"R29-4-20210126","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3109\/10428190009058509","article-title":"Atypical lymphocytes in B-cell chronic lymphocytic leukemia and trisomy 12 studied by conventional staining combined with fluorescence in situ hybridization","volume":"37","author":"Hjalmar","year":"2000","journal-title":"Leuk Lymphoma"},{"key":"R30-4-20210126","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1309\/AJCPXLY46UPFLISC","article-title":"Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes","volume":"131","author":"Yin","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"R31-4-20210126","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1309\/21TN2RUWKR827UW2","article-title":"Chronic lymphocytic leukemia FISH panel: impact on diagnosis","volume":"128","author":"Nelson","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"R32-4-20210126","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1046\/j.1365-2141.2000.01898.x","article-title":"Four novel non-random chromosome rearrangements in B-cell chronic lymphocytic leukaemia: 6p24-25 and 12p12-13 translocations, 4q21 anomalies and monosomy 21","volume":"108","author":"Cuneo","year":"2000","journal-title":"Br J Haematol"},{"key":"R33-4-20210126","first-page":"24","article-title":"Chromosome 6 abnormalities associated with prolymphocytic acceleration in chronic lymphocytic leukemia","volume":"28","author":"Glassman","year":"1998","journal-title":"Ann Clin Lab Sci"},{"key":"R34-4-20210126","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00000478-199801000-00006","article-title":"Lymph node histology in typical and atypical chronic lymphocytic leukemia","volume":"22","author":"Bonato","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"R35-4-20210126","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/00000478-200205000-00008","article-title":"Immunophenotype does not correlate with lymph node histology in chronic lymphocytic leukemia\/small lymphocytic lymphoma","volume":"26","author":"Asplund","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"R36-4-20210126","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.humpath.2005.09.029","article-title":"The proliferation center microenvironment and prognostic markers in chronic lymphocytic leukemia\/small lymphocytic lymphoma","volume":"37","author":"Soma","year":"2006","journal-title":"Hum Pathol"},{"key":"R37-4-20210126","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/jcp.2006.039586","article-title":"B cell chronic lymphocytic leukaemia\/small lymphocytic lymphoma: role of ZAP70 determination on bone marrow biopsy specimens","volume":"60","author":"Sabattini","year":"2007","journal-title":"J Clin Pathol"},{"key":"R38-4-20210126","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1182\/blood-2005-12-4986","article-title":"Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia","volume":"108","author":"Del Principe","year":"2006","journal-title":"Blood"},{"key":"R39-4-20210126","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1182\/blood.V99.3.1023","article-title":"CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease","volume":"99","author":"Hamblin","year":"2002","journal-title":"Blood"},{"key":"R40-4-20210126","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1182\/blood-2006-12-062265","article-title":"ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia","volume":"111","author":"Chen","year":"2008","journal-title":"Blood"},{"key":"R41-4-20210126","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.leukres.2006.05.024","article-title":"B-CLL cells from lymph nodes express higher ZAP-70 levels than B-CLL cells from peripheral blood","volume":"31","author":"Boelens","year":"2007","journal-title":"Leuk Res"},{"key":"R42-4-20210126","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/cncr.21437","article-title":"Zeta-chain associated protein 70 and CD38 combined predict the time to first treatment in patients with chronic lymphocytic leukemia","volume":"104","author":"Del Giudice","year":"2005","journal-title":"Cancer"}],"container-title":["Applied Immunohistochemistry &amp; Molecular Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00129039-201003000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:13:34Z","timestamp":1786040014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00129039-201003000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/pai.0b013e3181bbd5d5","relation":{},"ISSN":["1541-2016"],"issn-type":[{"value":"1541-2016","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}