{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T01:47:39Z","timestamp":1794534459759,"version":"4.9.1"},"reference-count":107,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1097\/pas.0000000000000533","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T08:05:04Z","timestamp":1447142704000},"page":"1730-1741","source":"Crossref","is-referenced-by-count":822,"title":["A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas"],"prefix":"10.1097","volume":"39","author":[{"given":"Olca","family":"Basturk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Mo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Volkan","family":"Adsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Albores-Saavedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew V.","family":"Biankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lodewijk A.A.","family":"Brosens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph H.","family":"Hruban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Klimstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Kl\u00f6ppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Krasinskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Longnecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Matthaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Johan A.","family":"Offerhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoichi","family":"Takaori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Terris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Yachida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210131","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/00000478-200105000-00003","article-title":". Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions.","volume":"25","author":"Hruban","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"R2-16-20210131","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/01.pas.0000126675.59108.80","article-title":". An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms.","volume":"28","author":"Hruban","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"R5-16-20210131","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1158\/0008-5472.CAN-05-2168","article-title":". Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.","volume":"66","author":"Hruban","year":"2006","journal-title":"Cancer Res"},{"key":"R6-16-20210131","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s005340200007","article-title":"p16 and p53 gene alterations and accumulations in the malignant evolution of intraductal papillary-mucinous tumors of the pancreas.","volume":"9","author":"Wada","year":"2002","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"R7-16-20210131","first-page":"1447","article-title":". Genetic progression and heterogeneity in intraductal papillary-mucinous neoplasms of the pancreas.","volume":"151","author":"Fujii","year":"1997","journal-title":"Am J Pathol"},{"key":"R8-16-20210131","first-page":"541","article-title":"P53 mutation but not p16MTS1 mutation occurs in intraductal papillary mucinous tumors of the pancreas.","volume":"50","author":"Mueller","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"R9-16-20210131","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/S0002-9440(10)61104-2","article-title":". Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma.","volume":"160","author":"Fukushima","year":"2002","journal-title":"Am J Pathol"},{"key":"R10-16-20210131","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1593\/neo.04445","article-title":". Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.","volume":"7","author":"Lohr","year":"2005","journal-title":"Neoplasia"},{"key":"R11-16-20210131","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00423-009-0579-4","article-title":". Widespread and multifocal carcinomas in situ (CISs) through almost the entire pancreas: report of a case with preoperative cytological diagnosis.","volume":"395","author":"Seki","year":"2010","journal-title":"Langenbecks Arch Surg"},{"key":"R12-16-20210131","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000346693","article-title":". Microinvasion of high-grade pancreatic intraepithelial neoplasia.","volume":"7","author":"Kawada","year":"2013","journal-title":"Case Rep Gastroenterol"},{"key":"R13-16-20210131","first-page":"3643","article-title":"Tang LH, et al..","volume":"20","author":"Konstantinidis","year":"2013","journal-title":"Incidentally discovered pancreatic intraepithelial neoplasia: what is its clinical significance Ann Surg Oncol"},{"key":"R14-16-20210131","doi-asserted-by":"crossref","first-page":"272","DOI":"10.4253\/wjge.v6.i7.272","article-title":"Endoscopic ultrasonography for surveillance of individuals at high risk for pancreatic cancer.","volume":"6","author":"Lami","year":"2014","journal-title":"World J Gastrointest Endosc"},{"key":"R15-16-20210131","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/MPA.0000000000000142","article-title":". Can endoscopic ultrasound predict pancreatic intraepithelial neoplasia lesions in chronic pancreatitis: a retrospective study of pathologic correlation.","volume":"43","author":"LeBlanc","year":"2014","journal-title":"Pancreas"},{"key":"R16-16-20210131","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000371842","article-title":". A case of pancreatic intraepithelial neoplasia that was difficult to diagnose preoperatively.","volume":"8","author":"Ito","year":"2015","journal-title":"Case Rep Oncol"},{"key":"R17-16-20210131","doi-asserted-by":"crossref","first-page":"e0117575","DOI":"10.1371\/journal.pone.0117575","article-title":". Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas.","volume":"10","author":"Matsuda","year":"2015","journal-title":"PLoS One"},{"key":"R18-16-20210131","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/1078-0432.CCR-14-2385","article-title":"Gaujoux S, dAssignies G, et al.. Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN).","volume":"21","author":"Rebours","year":"2015","journal-title":"Clin Cancer Res"},{"key":"R19-16-20210131","first-page":"89","article-title":"Bargello M, et al..","volume":"12","author":"Bartsch","year":"2013","journal-title":"Multiple small imaging branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia Fam Cancer"},{"key":"R20-16-20210131","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/SLA.0b013e31819a6e16","article-title":". Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma.","volume":"249","author":"Fritz","year":"2009","journal-title":"Ann Surg"},{"key":"R21-16-20210131","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1164368","article-title":". Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.","volume":"321","author":"Jones","year":"2008","journal-title":"Science"},{"key":"R22-16-20210131","doi-asserted-by":"crossref","first-page":"21188","DOI":"10.1073\/pnas.1118046108","article-title":". Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.","volume":"108","author":"Wu","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"R23-16-20210131","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/srep00161","article-title":". Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas.","volume":"1","author":"Furukawa","year":"2011","journal-title":"Sci Rep"},{"key":"R24-16-20210131","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/PAS.0b013e3182417d36","article-title":". Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors.","volume":"36","author":"Yachida","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"R25-16-20210131","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/path.4310","article-title":". Whole-exome sequencing of pancreatic neoplasms with acinar differentiation.","volume":"232","author":"Jiao","year":"2014","journal-title":"J Pathol"},{"key":"R26-16-20210131","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/modpathol.2013.154","article-title":". Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm of pancreas.","volume":"27","author":"Park","year":"2014","journal-title":"Mod Pathol"},{"key":"R27-16-20210131","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00428-014-1562-1","article-title":". APC alterations are frequently involved in the pathogenesis of acinar cell carcinoma of the pancreas, mainly through gene loss and promoter hypermethylation.","volume":"464","author":"Furlan","year":"2014","journal-title":"Virchows Arch"},{"key":"R28-16-20210131","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/MPA.0000000000000034","article-title":". PIK3CA mutations in mucinous cystic neoplasms of the pancreas.","volume":"43","author":"Garcia-Carracedo","year":"2014","journal-title":"Pancreas"},{"key":"R29-16-20210131","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pan.2012.04.004","article-title":". International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas.","volume":"12","author":"Tanaka","year":"2012","journal-title":"Pancreatology"},{"key":"R30-16-20210131","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1245\/s10434-011-1745-9","article-title":". Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer.","volume":"18","author":"Matthaei","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"R31-16-20210131","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1097\/01.MP.0000087422.24733.62","article-title":"Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma.","volume":"16","author":"Andea","year":"2003","journal-title":"Mod Pathol"},{"key":"R32-16-20210131","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/01.sla.0000216763.27673.97","article-title":". Periampullary and pancreatic incidentaloma: a single institutions experience with an increasingly common diagnosis.","volume":"243","author":"Winter","year":"2006","journal-title":"Ann Surg"},{"key":"R33-16-20210131","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2214\/AJR.07.3340","article-title":". Prevalence of unsuspected pancreatic cysts on MDCT.","volume":"191","author":"Laffan","year":"2008","journal-title":"Am J Roentgenol"},{"key":"R34-16-20210131","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4240\/wjgs.v2.i10.319","article-title":"Intraductal papillary mucinous neoplasm and the pancreatic incidentaloma.","volume":"2","author":"Kent","year":"2010","journal-title":"World J Gastrointest Surg"},{"key":"R35-16-20210131","first-page":"110","article-title":"Yeo CJ, et al..","volume":"27","author":"Abraham","year":"2003","journal-title":"Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: are they allchronic pancreatitis Am J Surg Pathol"},{"key":"R36-16-20210131","first-page":"572","article-title":". A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients.","volume":"244","author":"Allen","year":"2006","journal-title":"Ann Surg"},{"key":"R37-16-20210131","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s00428-005-0039-7","article-title":". Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study.","volume":"447","author":"Furukawa","year":"2005","journal-title":"Virchows Arch"},{"key":"R39-16-20210131","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s11605-014-2449-9","article-title":". Uncinate duct dilation in intraductal papillary mucinous neoplasms of the pancreas: a radiographic finding with potentially increased malignant potential.","volume":"18","author":"Ammori","year":"2014","journal-title":"J Gastrointest Surg"},{"key":"R40-16-20210131","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/MPA.0b013e31827a7b84","article-title":". Predictors of malignancy in intraductal papillary mucinous neoplasm of the pancreas: analysis of 310 pancreatic resection patients at multiple high-volume centers.","volume":"42","author":"Shimizu","year":"2013","journal-title":"Pancreas"},{"key":"R41-16-20210131","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/MPA.0b013e3182480c44","article-title":". Malignant transformation of branch duct-type intraductal papillary mucinous neoplasms of the pancreas based on contrast-enhanced endoscopic ultrasonography morphological changes: focus on malignant transformation of intraductal papillary mucinous neoplasm itself.","volume":"41","author":"Ohno","year":"2012","journal-title":"Pancreas"},{"key":"R42-16-20210131","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3346\/jkms.2011.26.6.740","article-title":". Determination of malignant and invasive predictors in branch duct type intraductal papillary mucinous neoplasms of the pancreas: a suggested scoring formula.","volume":"26","author":"Hwang","year":"2011","journal-title":"J Korean Med Sci"},{"key":"R43-16-20210131","first-page":"613","article-title":". Utility of 2-18F fluoro-2-deoxy-D-glucose positron emission tomography in differential diagnosis of benign and malignant intraductal papillary-mucinous neoplasm of the pancreas.","volume":"24","author":"Tomimaru","year":"2010","journal-title":"Oncol Rep"},{"key":"R44-16-20210131","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1097\/MCG.0b013e3181d8fb91","article-title":". Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas.","volume":"44","author":"Mimura","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"R45-16-20210131","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/MPA.0b013e3181d6ba04","article-title":". MUC1 is a useful molecular marker for malignant intraductal papillary mucinous neoplasms in pancreatic juice obtained from endoscopic retrograde pancreatography.","volume":"39","author":"Shimamoto","year":"2010","journal-title":"Pancreas"},{"key":"R46-16-20210131","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s11605-009-1001-9","article-title":". Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms.","volume":"13","author":"Bausch","year":"2009","journal-title":"J Gastrointest Surg"},{"key":"R47-16-20210131","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1158\/1055-9965.EPI-08-0417","article-title":". A population-based, descriptive analysis of malignant intraductal papillary mucinous neoplasms of the pancreas.","volume":"17","author":"Le","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R48-16-20210131","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.amjsurg.2011.01.003","article-title":". Predicting malignant intraductal papillary mucinous neoplasm: a single-center review.","volume":"201","author":"Cone","year":"2011","journal-title":"Am J Surg"},{"key":"R49-16-20210131","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/bjs.7280","article-title":". Role of serum carbohydrate antigen 19-9 and carcinoembryonic antigen in distinguishing between benign and invasive intraductal papillary mucinous neoplasm of the pancreas.","volume":"98","author":"Fritz","year":"2011","journal-title":"Br J Surg"},{"key":"R50-16-20210131","first-page":"251","article-title":"Shah SA, et al..","volume":"167","author":"Simons","year":"2011","journal-title":"Malignant intraductal papillary mucinous neoplasm: are we doing the right thing J Surg Res"},{"key":"R52-16-20210131","first-page":"1451","article-title":"Lawler LP, et al..","volume":"25","author":"Kawamoto","year":"2005","journal-title":"Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT Radiographics"},{"key":"R53-16-20210131","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1148\/radiol.2531080604","article-title":". Main pancreatic duct intraductal papillary mucinous neoplasms: accuracy of MR imaging in differentiation between benign and malignant tumors compared with histopathologic analysis.","volume":"253","author":"Manfredi","year":"2009","journal-title":"Radiology"},{"key":"R54-16-20210131","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00430702","article-title":". Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis.","volume":"387","author":"Kloppel","year":"1980","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"R55-16-20210131","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/ajcp\/77.2.137","article-title":"Hyperplastic preneoplastic and neoplastic lesions found in 83 human pancreases.","volume":"77","author":"Pour","year":"1982","journal-title":"Am J Clin Pathol"},{"key":"R56-16-20210131","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/s00428-005-0032-1","article-title":". Pancreatic fibrosis associated with age and ductal papillary hyperplasia.","volume":"447","author":"Detlefsen","year":"2005","journal-title":"Virchows Arch"},{"key":"R57-16-20210131","first-page":"1103","article-title":". Pancreatic intraepithelial neoplasms in the normal appearing pancreas: on their precise relationship with age.","volume":"55","author":"Ito","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"R58-16-20210131","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.semdp.2014.08.004","article-title":"Adenocarcinoma of the pancreas.","volume":"31","author":"Hruban","year":"2014","journal-title":"Semin Diagn Pathol"},{"key":"R59-16-20210131","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000478-199802000-00003","article-title":". Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas.","volume":"22","author":"Brat","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"R60-16-20210131","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/hupa.2001.24991","article-title":". Pancreatic intraepithelial neoplasia and infiltrating adenocarcinoma: analysis of progression and recurrence by DPC4 immunohistochemical labeling.","volume":"32","author":"McCarthy","year":"2001","journal-title":"Hum Pathol"},{"key":"R61-16-20210131","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.surg.2010.03.013","article-title":". Prognostic impact of pancreatic margin status in the intraductal papillary mucinous neoplasms of the pancreas.","volume":"148","author":"Fujii","year":"2010","journal-title":"Surgery"},{"key":"R62-16-20210131","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1245\/s10434-007-9546-x","article-title":". Surgical outcome of intraductal papillary mucinous neoplasms of the pancreas.","volume":"14","author":"Nakagohri","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"R63-16-20210131","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1245\/ASO.2006.05.002","article-title":". Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival.","volume":"13","author":"Raut","year":"2006","journal-title":"Ann Surg Oncol"},{"key":"R64-16-20210131","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000339334","article-title":". Impact of pancreatic margin status and lymph node metastases on recurrence after resection for invasive and noninvasive intraductal papillary mucinous neoplasms of the pancreas: a meta-analysis.","volume":"29","author":"Leng","year":"2012","journal-title":"Dig Surg"},{"key":"R65-16-20210131","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/hpb.12137","article-title":". Dysplasia at the surgical margin is associated with recurrence after resection of non-invasive intraductal papillary mucinous neoplasms.","volume":"15","author":"Frankel","year":"2013","journal-title":"HPB (Oxford)"},{"key":"R67-16-20210131","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/SLA.0000000000000470","article-title":". Long-term prospective cohort study of patients undergoing pancreatectomy for intraductal papillary mucinous neoplasm of the pancreas: implications for postoperative surveillance.","volume":"260","author":"Kang","year":"2014","journal-title":"Ann Surg"},{"key":"R68-16-20210131","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ijscr.2013.05.009","article-title":"Recurrence of non-invasive intraductal papillary municious neoplasm seven years following total pancreatectomy.","volume":"4","author":"Dejean","year":"2013","journal-title":"Int J Surg Case Rep"},{"key":"R69-16-20210131","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000231982","article-title":". Incidence of synchronous and metachronous pancreatic carcinoma in 168 patients with branch duct intraductal papillary mucinous neoplasm.","volume":"10","author":"Tanno","year":"2010","journal-title":"Pancreatology"},{"key":"R70-16-20210131","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1002\/cncr.22301","article-title":". Role of intraoperative cytology combined with histology in detecting continuous and skip type intraductal cancer existence for intraductal papillary mucinous carcinoma of the pancreas.","volume":"107","author":"Eguchi","year":"2006","journal-title":"Cancer"},{"key":"R71-16-20210131","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.5858\/2002-126-1169-FSDOPL","article-title":". Frozen section diagnosis of pancreatic lesions.","volume":"126","author":"Cioc","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"R72-16-20210131","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1001\/archsurg.136.11.1256","article-title":". Surgical management of intraductal papillary mucinous tumors of the pancreas: the role of routine frozen section of the surgical margin, intraoperative endoscopic staged biopsies of the Wirsung duct, and pancreaticogastric anastomosis.","volume":"136","author":"Gigot","year":"2001","journal-title":"Arch Surg"},{"key":"R74-16-20210131","doi-asserted-by":"crossref","first-page":"92ra66","DOI":"10.1126\/scitranslmed.3002543","article-title":". Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.","volume":"3","author":"Wu","year":"2011","journal-title":"Sci Transl Med"},{"key":"R76-16-20210131","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/PAS.0000000000000117","article-title":". GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as incipient IPMNs.","volume":"38","author":"Matthaei","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"R77-16-20210131","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1159\/000064716","article-title":". Intraductal papillary-mucinous tumor of the pancreas concomitant with ductal carcinoma of the pancreas.","volume":"2","author":"Yamaguchi","year":"2002","journal-title":"Pancreatology"},{"key":"R78-16-20210131","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/MPA.0b013e318215010c","article-title":". Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN.","volume":"40","author":"Yamaguchi","year":"2011","journal-title":"Pancreas"},{"key":"R79-16-20210131","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/SLA.0b013e31828cd008","article-title":". Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype.","volume":"258","author":"Ideno","year":"2013","journal-title":"Ann Surg"},{"key":"R80-16-20210131","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1159\/000065089","article-title":". Intraductal spread of pancreatic cancer. Clinicopathologic study of 54 pancreatectomized patients.","volume":"2","author":"Yamasaki","year":"2002","journal-title":"Pancreatology"},{"key":"R81-16-20210131","first-page":"154","article-title":"Schroder S, et al..","volume":"15","author":"Kosmahl","year":"2002","journal-title":"Mucinous nonneoplastic cyst of the pancreas: a novel nonneoplastic cystic change Mod Pathol"},{"key":"R82-16-20210131","first-page":"445A","article-title":". Cystic mucinous duct lesion of the pancreas: a clinicopathologic analysis of 40 examples of a diagnostically challenging and terminologically controversial entity.","volume":"25","author":"Krasinskas","year":"2012","journal-title":"Mod Pathol"},{"key":"R83-16-20210131","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2007.02.020","article-title":"A case of mistaken identity Nonductal origins of pancreatic ductal cancers.","volume":"11","author":"Murtaugh","year":"2007","journal-title":"Cancer Cell"},{"key":"R84-16-20210131","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF01536153","article-title":"Histochemical and ultrastructural characteristics of tubular complexes in human acute pancreatitis.","volume":"34","author":"Willemer","year":"1989","journal-title":"Dig Dis Sci"},{"key":"R85-16-20210131","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/01.LAB.0000074918.31303.5A","article-title":". Origin and development of the precursor lesions in experimental pancreatic cancer in rats.","volume":"83","author":"Bockman","year":"2003","journal-title":"Lab Invest"},{"key":"R86-16-20210131","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1038\/onc.2012.210","article-title":". Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.","volume":"32","author":"Shi","year":"2013","journal-title":"Oncogene"},{"key":"R87-16-20210131","doi-asserted-by":"crossref","first-page":"18907","DOI":"10.1073\/pnas.0810111105","article-title":". Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.","volume":"105","author":"De La","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"R88-16-20210131","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":". Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.","volume":"11","author":"Guerra","year":"2007","journal-title":"Cancer Cell"},{"key":"R89-16-20210131","doi-asserted-by":"crossref","first-page":"18913","DOI":"10.1073\/pnas.0810097105","article-title":". Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice.","volume":"105","author":"Habbe","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"R90-16-20210131","doi-asserted-by":"crossref","first-page":"e16786","DOI":"10.1371\/journal.pone.0016786","article-title":". Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model.","volume":"6","author":"Ray","year":"2011","journal-title":"PLoS One"},{"key":"R91-16-20210131","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ccr.2012.10.025","article-title":". Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.","volume":"22","author":"Kopp","year":"2012","journal-title":"Cancer Cell"},{"key":"R92-16-20210131","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0002-9610(82)90518-9","article-title":"Origin of tubular complexes in human chronic pancreatitis.","volume":"144","author":"Bockman","year":"1982","journal-title":"Am J Surg"},{"key":"R93-16-20210131","first-page":"1285","article-title":". Ductal metaplasia of human exocrine pancreas and its association with carcinoma.","volume":"45","author":"Parsa","year":"1985","journal-title":"Cancer Res"},{"key":"R94-16-20210131","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/mpa.0b013e31805d0190","article-title":". Hypothetical progression model of pancreatic cancer with origin in the centroacinar-acinar compartment.","volume":"35","author":"Esposito","year":"2007","journal-title":"Pancreas"},{"key":"R95-16-20210131","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1158\/1541-7786.MCR-08-0206","article-title":". KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.","volume":"7","author":"Shi","year":"2009","journal-title":"Mol Cancer Res"},{"key":"R96-16-20210131","first-page":"1067","article-title":". Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.","volume":"30","author":"Brune","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"R97-16-20210131","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/path.3017","article-title":". Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.","volume":"226","author":"Aichler","year":"2012","journal-title":"J Pathol"},{"key":"R98-16-20210131","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.pan.2013.04.042","article-title":". Characterization of putative precursor lesions of familial pancreatic cancer.","volume":"13","author":"Konukiewitz","year":"2013","journal-title":"Pancreatology"},{"key":"R99-16-20210131","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.amjsurg.2010.06.020","article-title":". Mural nodule in branch duct-type intraductal papillary mucinous neoplasms of the pancreas is a marker of malignant transformation and indication for surgery.","volume":"202","author":"Akita","year":"2011","journal-title":"Am J Surg"},{"key":"R100-16-20210131","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/01.sla.0000124386.54496.15","article-title":". Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection.","volume":"239","author":"Salvia","year":"2004","journal-title":"Ann Surg"},{"key":"R101-16-20210131","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/bjs.4265","article-title":". Predictive factors for malignancy in intraductal papillary-mucinous tumours of the pancreas.","volume":"90","author":"Sugiyama","year":"2003","journal-title":"Br J Surg"},{"key":"R102-16-20210131","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1097\/00000478-200010000-00006","article-title":". Intraductal papillary mucinous tumors of the pancreas confined to secondary ducts show less aggressive pathologic features as compared with those involving the main pancreatic duct.","volume":"24","author":"Terris","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"R103-16-20210131","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00004728-200401000-00020","article-title":". Natural history of pancreatic intraductal papillary mucinous tumor of branch duct type: follow-up study by magnetic resonance cholangiopancreatography.","volume":"28","author":"Irie","year":"2004","journal-title":"J Comput Assist Tomogr"},{"key":"R104-16-20210131","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/MPA.0b013e3181bab60e","article-title":". Cyst size indicates malignant transformation in branch duct intraductal papillary mucinous neoplasm of the pancreas without mural nodules.","volume":"39","author":"Sadakari","year":"2010","journal-title":"Pancreas"},{"key":"R105-16-20210131","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/MPA.0b013e31820a5975","article-title":". Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas: a multicenter study in Japan.","volume":"40","author":"Maguchi","year":"2011","journal-title":"Pancreas"},{"key":"R106-16-20210131","first-page":"1086","article-title":"Falconi M, et al..","volume":"56","author":"Salvia","year":"2007","journal-title":"Branch-duct intraductal papillary mucinous neoplasms of the pancreas: to operate or not to operate Gut"},{"key":"R107-16-20210131","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/gut.2007.129684","article-title":". Natural history of branch duct intraductal papillary-mucinous neoplasms of the pancreas without mural nodules: long-term follow-up results.","volume":"57","author":"Tanno","year":"2008","journal-title":"Gut"},{"key":"R108-16-20210131","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0046-8177(88)80344-7","article-title":". Observer variation in the diagnosis of dysplasia in Barretts esophagus.","volume":"19","author":"Reid","year":"1988","journal-title":"Hum Pathol"},{"key":"R109-16-20210131","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/jcp.43.4.320","article-title":". Observer reproducibility in grading dysplasia in colorectal adenomas: comparison between two different grading systems.","volume":"43","author":"Fenger","year":"1990","journal-title":"J Clin Pathol"},{"key":"R110-16-20210131","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02052450","article-title":". Observer variability in the assessment of type and dysplasia of colorectal adenomas, analyzed using kappa statistics.","volume":"38","author":"Jensen","year":"1995","journal-title":"Dis Colon Rectum"},{"key":"R111-16-20210131","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/00000478-199508000-00002","article-title":". Interobserver reproducibility in the diagnosis of prostatic intraepithelial neoplasia.","volume":"19","author":"Epstein","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"R112-16-20210131","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1097\/AOG.0b013e31827001d5","article-title":". Revised terminology for cervical histopathology and its implications for management of high-grade squamous intraepithelial lesions of the cervix.","volume":"120","author":"Waxman","year":"2012","journal-title":"Obstet Gynecol"},{"key":"R113-16-20210131","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/PGP.0b013e31826916c7","article-title":". The Lower Anogenital Squamous Terminology Standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology.","volume":"32","author":"Darragh","year":"2013","journal-title":"Int J Gynecol Pathol"},{"key":"R114-16-20210131","first-page":"227","article-title":". Varying grades of epithelial atypia in the pancreatic ducts of humans. Classification based on morphometry and multivariate analysis and correlated with positive reactions of carcinoembryonic antigen.","volume":"118","author":"Furukawa","year":"1994","journal-title":"Arch Pathol Lab Med"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PAS.0000000000000533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:45:47Z","timestamp":1620953147000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000478-201512000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":107,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0000000000000533","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}