{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:52:51Z","timestamp":1754110371322},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Hepatoblastoma is the most common malignant liver tumor in childhood. It has been associated with a variety of constitutional syndromes and gene mutations. However, there are very few reports of associations with pediatric hepatocellular adenomas (HCAs) and no reported associations with pigmented HCAs (P-HCAs). We present a unique case of hepatoblastoma arising in a background of 2 \u03b2-catenin-activated HCAs, one of which is pigmented, in a 4-year-old child. The gross, histologic, and immunohistochemical features are described for each tumor. In addition, the literature is reviewed with specific emphasis on the clinical and pathologic features of B-HCAs. Although the potential of \u03b2-catenin-activated HCAs to progress to hepatocellular carcinoma has been well documented, there are very few reports of their potential to progress to hepatoblastoma. We not only present such a case, but, to our knowledge, we also present the first case of a P-HCA in a child.<\/jats:p>","DOI":"10.1097\/pas.0000000000000652","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T17:23:52Z","timestamp":1461086632000},"page":"998-1003","source":"Crossref","is-referenced-by-count":6,"title":["Hepatoblastoma Arising in a Pigmented \u03b2-catenin-activated Hepatocellular Adenoma"],"prefix":"10.1097","volume":"40","author":[{"given":"Christine Y.","family":"Louie","sequence":"first","affiliation":[{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldo","family":"Concepcion","sequence":"additional","affiliation":[{"name":"Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph K.","family":"Park","sequence":"additional","affiliation":[{"name":"Pediatrics, Stanford University School of Medicine, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Rangaswami","sequence":"additional","affiliation":[{"name":"Pediatrics, Stanford University School of Medicine, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton J.","family":"Finegold","sequence":"additional","affiliation":[{"name":"Pathology"},{"name":"Immunology and Pediatrics, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florette K.","family":"Hazard","sequence":"additional","affiliation":[{"name":"Pathology"},{"name":"Pediatrics, Stanford University School of Medicine, Stanford, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230922","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1056\/NEJM197602262940904","article-title":"Liver-cell adenomas associated with use of oral contraceptives","volume":"294","author":"Edmondson","year":"1976","journal-title":"N Engl J Med"},{"key":"R2-20230922","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1097\/PAS.0b013e31828aeb18","article-title":"Multifocal hepatic neoplasia in 3 children with APC gene mutation","volume":"37","author":"Gupta","year":"2013","journal-title":"Am J Surg Pathol"},{"issue":"suppl 1","key":"R3-20230922","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1007\/BF02679993","article-title":"Glycogen storage disease type I: pathophysiology of liver adenomas","volume":"161","author":"Lee","year":"2002","journal-title":"Eur J Pediatr"},{"key":"R4-20230922","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1097\/MEG.0b013e3282f824e9","article-title":"Liver tumours in patients with Fanconi anaemia: a report of three cases","volume":"20","author":"Ozenne","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R5-20230922","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1097\/00000478-199510000-00008","article-title":"Clinicopathological observations and assessment of cell proliferative activity","volume":"19","author":"Resnick","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"R6-20230922","first-page":"2962","article-title":"Spontaneous hepatocellular adenoma in paediatric age group - case report","volume":"7","author":"Vaithianathan","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"R7-20230922","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.21068","article-title":"Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC","volume":"43","author":"Zucman-Rossi","year":"2006","journal-title":"Hepatology"},{"key":"R8-20230922","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/00000478-200010000-00015","article-title":"Pigmented liver cell adenoma in two male patients","volume":"24","author":"Hasan","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"R9-20230922","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/PAS.0b013e318218ca3f","article-title":"Hepatocellular carcinoma arising in a pigmented telangiectatic adenoma with nuclear beta-catenin and glutamine synthetase positivity: case report and review of the literature","volume":"35","author":"Hechtman","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"R10-20230922","doi-asserted-by":"crossref","first-page":"452","DOI":"10.5009\/gnl.2014.8.4.452","article-title":"Beta-Catenin activated hepatocellular adenoma: a report of three cases in Korea","volume":"8","author":"Kim","year":"2014","journal-title":"Gut Liver"},{"key":"R11-20230922","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1445-2197.2011.05937.x","article-title":"Pigmented liver cell adenoma: rare but benign","volume":"82","author":"Koea","year":"2012","journal-title":"ANZ J Surg"},{"key":"R12-20230922","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00595-010-4344-7","article-title":"Pigmented hepatocellular adenoma: report of a case","volume":"41","author":"Masuda","year":"2011","journal-title":"Surg Today"},{"key":"R13-20230922","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/hpb.12112","article-title":"Predictors of survival and incidence of hepatoblastoma in the paediatric population","volume":"15","author":"Allan","year":"2013","journal-title":"HPB (Oxford)"},{"key":"R14-20230922","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/pbc.24215","article-title":"The epidemiology of hepatoblastoma","volume":"59","author":"Spector","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"R15-20230922","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1038\/sj.onc.1206118","article-title":"New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism","volume":"21","author":"Cadoret","year":"2002","journal-title":"Oncogene"},{"key":"R16-20230922","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/sj.onc.1209824","article-title":"Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas","volume":"26","author":"Zucman-Rossi","year":"2007","journal-title":"Oncogene"},{"key":"R17-20230922","first-page":"269","article-title":"Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene","volume":"59","author":"Koch","year":"1999","journal-title":"Cancer Res"},{"key":"R18-20230922","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/gut.39.6.867","article-title":"Hepatoblastoma and APC gene mutation in familial adenomatous polyposis","volume":"39","author":"Giardiello","year":"1996","journal-title":"Gut"},{"key":"R19-20230922","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jpeds.2005.04.019","article-title":"The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds","volume":"147","author":"Hirschman","year":"2005","journal-title":"J Pediatr"},{"key":"R20-20230922","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1097\/00042737-200012110-00015","article-title":"Multiple black hepatocellular adenomas in a male patient","volume":"12","author":"Bernard","year":"2000","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R21-20230922","doi-asserted-by":"crossref","first-page":"528","DOI":"10.4103\/0377-4929.107801","article-title":"Pigmented hepatocellular adenoma with complete CD34 immunostaining pattern: a diagnostic dilemma","volume":"55","author":"Vij","year":"2012","journal-title":"Indian J Pathol Microbiol"},{"key":"R22-20230922","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-2007-1007123","article-title":"A 42-year-old woman with liver masses and long-term use of oral contraceptives","volume":"19","author":"Ye","year":"1999","journal-title":"Semin Liver Dis"},{"key":"R23-20230922","first-page":"192","article-title":"Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital","volume":"82","author":"Ferko","year":"2003","journal-title":"Rozhl Chir"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00000478-201607000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T22:17:06Z","timestamp":1695421026000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000478-201607000-00016"}},"subtitle":["Case Report and Review of the Literature"],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0000000000000652","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}