{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T10:00:58Z","timestamp":1794650458634,"version":"4.9.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Brenner tumors are uncommon ovarian neoplasms, which have morphologic and immunophenotypical features of transitional cell (urothelial) differentiation. The origin of Brenner tumors is perplexing, but they are believed to arise from transitional cell metaplasia occurring within the ovary and\/or fallopian tube, although it is controversial whether this metaplasia is truly along transitional cell lines. Recently, <jats:italic toggle=\"yes\">TERT<\/jats:italic> promoter mutations have been identified in urothelial carcinoma (UC) with high frequency (approximately 70%), and the current literature suggests a potential diagnostic and\/or prognostic role of these mutations in UC. Molecular evidence supporting that Brenner tumors represent neoplasms exhibiting transitional cell differentiation is scant. To explore this further, we investigated a series of 19 Brenner tumors of the ovary (15 benign and 4 malignant) for the presence of <jats:italic toggle=\"yes\">TERT<\/jats:italic> promoter mutations after genomic DNA extraction from formalin-fixed paraffin-embedded tissue blocks and standard polymerase chain reaction sequencing. <jats:italic toggle=\"yes\">TERT<\/jats:italic> promoter mutations were not identified in any of the cases (0\/19). The absence of <jats:italic toggle=\"yes\">TERT<\/jats:italic> promoter mutations in Brenner tumors suggests that despite the morphologic and some immunophenotypical resemblance to non-neoplastic and neoplastic transitional epithelium, Brenner tumors may exhibit a molecularly distinct pathogenesis. The findings also may portend diagnostic utility in rare cases wherein it is difficult to distinguish a primary malignant Brenner tumor of the ovary from metastatic UC.<\/jats:p>","DOI":"10.1097\/pas.0000000000000680","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T11:59:17Z","timestamp":1465905557000},"page":"1291-1295","source":"Crossref","is-referenced-by-count":18,"title":["Benign and Malignant Brenner Tumors Show an Absence of TERT Promoter Mutations That Are Commonly Present in Urothelial Carcinoma"],"prefix":"10.1097","volume":"40","author":[{"given":"Francesca","family":"Khani","sequence":"first","affiliation":[{"name":"Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairo L.","family":"Diolombi","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Khattar","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Westchester Medical Center\/New York Medical College, Valhalla, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Huang","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Westchester Medical Center\/New York Medical College, Valhalla, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Fallon","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Westchester Medical Center\/New York Medical College, Valhalla, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan I.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, 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