{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T10:28:37Z","timestamp":1794652117615,"version":"4.9.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>A third to half of penile invasive squamous cell carcinomas are human papillomavirus (HPV) related. Warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with HPV. Less frequent are clear cell and lymphoepithelioma-like carcinomas. Here we report a novel penile tumor associated with HPV. Twelve cases were selected from 1010 penile carcinomas, part of an international HPV detection study conducted at the Institut Catal\u00e0 d\u2019Oncologia, Barcelona, Spain. Immunostaining with p16<jats:sup>INK4a<\/jats:sup> was performed on all cases, and HPV-mRNA detection was also performed. En bloc full tumor staining was the utilized criteria for positivity of p16<jats:sup>INK4a<\/jats:sup>. For HPV-DNA detection, whole-tissue section polymerase chain reaction analysis was performed by SPF<jats:sub>10<\/jats:sub>-DEIA-LiPA<jats:sub>25<\/jats:sub> (version 1). The patients\u2019 ages ranged from 42 to 92 years (average, 71 y). The tumor was most commonly located in the glans. A characteristic microscopic finding was the presence of a moderate to dense tumor-associated inflammatory cell infiltrate composed of neutrophils, lymphocytes, plasma cells, or eosinophils. Tumors grew in large solid sheets, nests, or had a trabecular pattern. Cells were large and poorly differentiated or anaplastic. Keratinization was minimal or absent. Nuclei were large with prominent nucleoli. Mitoses were numerous. Tumor necrosis was common. Deep invasion of the corpora cavernosa was frequent. p16<jats:sup>INK4a<\/jats:sup> and HPV-DNA were positive in all cases, whereas mRNA detection was positive in 9 cases only. The prevalent genotype was HPV16 (9 cases, 75%). Other genotypes were HPVs 58, 33, and 66. Medullary carcinomas of the penis are morphologically distinctive HPV-related high-grade neoplasms affecting older individuals. More studies are necessary to delineate the epidemiological, clinical, and molecular features of this unusual penile neoplasm.<\/jats:p>","DOI":"10.1097\/pas.0000000000000779","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:29:20Z","timestamp":1489508960000},"page":"535-540","source":"Crossref","is-referenced-by-count":28,"title":["Medullary Carcinoma of the Penis"],"prefix":"10.1097","volume":"41","author":[{"given":"Sof\u00eda","family":"Ca\u00f1ete-Portillo","sequence":"first","affiliation":[{"name":"Instituto de Patolog\u00eda e Investigaci\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Clavero","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO)-IDIBELL, L\u2019Hospitalet de Llobregat, Gran Via de l\u2019Hospitalet, Barcelona"},{"name":"CIBER Epidemiology and Public Health, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego F.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Instituto de Patolog\u00eda e Investigaci\u00f3n"},{"name":"School of Medicine, National University of Asuncion - UNA, Asunci\u00f3n, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Silvero","sequence":"additional","affiliation":[{"name":"Instituto de Patolog\u00eda e Investigaci\u00f3n"},{"name":"School of Medicine, National University of Asuncion - UNA, Asunci\u00f3n, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Abed","sequence":"additional","affiliation":[{"name":"Instituto de Patolog\u00eda e Investigaci\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Instituto de Patolog\u00eda e Investigaci\u00f3n"},{"name":"School of Medicine, National University of Asuncion - UNA, Asunci\u00f3n, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Ayala","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Alemany","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO)-IDIBELL, L\u2019Hospitalet de Llobregat, Gran Via de l\u2019Hospitalet, Barcelona"},{"name":"CIBER Epidemiology and Public Health, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nubia","family":"Munoz","sequence":"additional","affiliation":[{"name":"National Institute of Cancer, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"de Sanjose","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO)-IDIBELL, L\u2019Hospitalet de Llobregat, Gran Via de l\u2019Hospitalet, Barcelona"},{"name":"CIBER Epidemiology and Public Health, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Quint","sequence":"additional","affiliation":[{"name":"DDL Diagnostic Laboratory, Rijswijk, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc X.","family":"Bosch","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO)-IDIBELL, L\u2019Hospitalet de Llobregat, Gran Via de l\u2019Hospitalet, Barcelona"},{"name":"CIBER Epidemiology and Public Health, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio L.","family":"Cubilla","sequence":"additional","affiliation":[{"name":"Instituto de Patolog\u00eda e Investigaci\u00f3n"},{"name":"School of Medicine, National University of Asuncion - UNA, Asunci\u00f3n, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230922","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00000478-199302000-00005","article-title":"Basaloid and warty carcinomas of the vulva. 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