{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:45:37Z","timestamp":1790635537923,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Isolated <jats:italic toggle=\"yes\">MYC<\/jats:italic> rearrangement without other recurrent genetic abnormalities is rare in B lymphoblastic leukemia\/lymphoma (B-ALL\/LBL), with most cases reported in pediatric patients. We report 3 adult cases with lymphoblasts showing a precursor B cell immunophenotype, and isolated <jats:italic toggle=\"yes\">MYC<\/jats:italic>\/IGH translocation. All 3 cases occurred in male patients with initial presentation of diffuse lymphadenopathy. Cases 1 and 2 had B-ALL with significantly increased lymphoblasts in peripheral blood and bone marrow. Case 3, a patient with human immunodeficiency virus infection, had the diagnosis of B-LBL made on a retroperitoneal lymph node biopsy and had no peripheral blood or bone marrow involvement. The leukemic and lymphoma cells in all 3 cases demonstrated Burkitt lymphoma-like morphology with deeply basophilic cytoplasm and numerous cytoplasmic vacuoles. However, all 3 had immature immunophenotypes including expression of terminal deoxynucleotidyl transferase (TdT), absence of BCL6, and dim-to-negative CD45. CD20 was largely negative in 2 of 3 cases. All 3 had confirmed <jats:italic toggle=\"yes\">MYC<\/jats:italic>\/IGH translocation, but lacked rearrangements of <jats:italic toggle=\"yes\">BCL2<\/jats:italic> or <jats:italic toggle=\"yes\">BCL6<\/jats:italic>. EBV was negative by Epstein-Barr virus encoded small RNA in situ hybridization. Treatment protocols varied, including both high-risk ALL-type (protocol 8707) and high-grade lymphoma regimens (hyper-CVAD [cyclophosphamide, vincristine, adriamycin, and dexamethasone]), but no patient achieved continuous complete remission. These cases seem to represent a distinct biological phenomenon, in which a <jats:italic toggle=\"yes\">MYC<\/jats:italic> translocation may be acquired at an immature stage of differentiation, thus manifesting features of both B-ALL\/LBL and Burkitt lymphoma.<\/jats:p>","DOI":"10.1097\/pas.0000000000000982","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T21:15:29Z","timestamp":1510780529000},"page":"269-276","source":"Crossref","is-referenced-by-count":32,"title":["B Lymphoblastic Leukemia\/Lymphoma With Burkitt-like Morphology and IGH\/MYC Rearrangement"],"prefix":"10.1097","volume":"42","author":[{"given":"Yiting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, San Francisco Medical Center, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology and 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