{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:31:32Z","timestamp":1782257492458,"version":"3.54.5"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Granular cell tumors are lesions of Schwannian phenotype that most frequently arise in the skin, breast, and tongue. Pulmonary granular cell tumors (pGCTs) are exceedingly rare and only a handful of cases worldwide have been reported as malignant. We report here a series of 4 pGCTs, including an extremely rare case of a malignant pGCT which underwent next-generation sequencing to identify a novel pathogenic mutation. We are the first to report any prognostic data and response to treatment. Consistent with granular cell tumors of other primary sites, the majority of pGCTs (75%) were deemed histologically and biological benign without metastasis or recurrence after resection (mean follow-up, 750\u2009d). pGCTs occurred predominantly in women (75%) with a mean age of 57 years (range, 49 to 66\u2009y) and variable smoking history. Notably, 2 women also developed an associated lung carcinoma (adenocarcinoma and small cell carcinoma). We also report here an exceedingly rare case of a 51-year-old nonsmoker woman diagnosed with a malignant pGCT. She presented with a 6.4\u00d76.1\u00d74.4\u2009cm infrahilar left lower lobe mass with extrinsic compression and obstruction of the left mainstem on enhanced computed tomography. Pathology of the resection specimen confirmed a pGCT composed of sheets of tumor cells with pleural, pericardial, and diaphragmatic metastases. Molecular analysis by next-generation sequencing failed to yield any driver mutations common to primary lung adenocarcinomas. Only 2 previous malignant pGCTs have been reported; our case revealed a novel pathologic <jats:italic toggle=\"yes\">ATM<\/jats:italic> mutation.<\/jats:p>","DOI":"10.1097\/pas.0000000000001303","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T04:35:06Z","timestamp":1560141306000},"page":"1397-1402","source":"Crossref","is-referenced-by-count":9,"title":["Pulmonary Granular Cell Tumors"],"prefix":"10.1097","volume":"43","author":[{"given":"Richard","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Deak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn H.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230922","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02078314","article-title":"\u00dcber Myome ausgehend von der quergestreiften willk\u00fcrlichen Muskulatur","volume":"260","author":"Abrikossoff","year":"1926","journal-title":"Virchows Archiv"},{"key":"R2-20230922","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0022-5223(03)00601-9","article-title":"Granular cell tumors of the tracheobronchial tree","volume":"126","author":"van der Maten","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R3-20230922","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/00000478-199506000-00002","article-title":"Granular cell tumors of the lung. 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