{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:16:37Z","timestamp":1790691397577,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>The use of lymphoid interstitial pneumonia (LIP) as a diagnostic term has changed considerably since its introduction. Utilizing a multi-institutional collection of 201 cases from the last 20 years that demonstrate features associated with the LIP rubric, we compared cases meeting strict histologic criteria of LIP per American Thoracic Society (ATS)\/European Respiratory Society (ERS) consensus (\u201cpathologic LIP\u201d; n=62) with cystic cases fulfilling radiologic ATS\/ERS criteria (\u201cradiologic LIP\u201d; n=33) and with other diffuse benign lymphoid proliferations. \u201cPathologic LIP\u201d was associated with immune dysregulation including autoimmune disorders and immune deficiency, whereas \u201cradiologic LIP\u201d was only seen with autoimmune disorders. No case of idiopathic LIP was found. On histology, \u201cpathologic LIP\u201d represented a subgroup of 70% (62\/88) of cases with the distinctive pattern of diffuse expansile lymphoid infiltrates. In contrast, \u201cradiologic LIP\u201d demonstrated a broad spectrum of inflammatory patterns, airway-centered inflammation being most common (52%; 17\/33). Only 5 cases with radiologic cysts also met consensus ATS\/ERS criteria for \u201cpathologic LIP.\u201d Overall, broad overlap was observed with the remaining study cases that failed to meet consensus criteria for \u201cradiologic LIP\u201d and\/or \u201cpathologic LIP.\u201d These data raise concerns about the practical use of the term LIP as currently defined. What radiologists and pathologist encounter as LIP differs remarkably, but neither \u201cradiologic LIP\u201d nor \u201cpathologic LIP\u201d present with sufficiently distinct findings to delineate such cases from other patterns of diffuse benign lymphoid proliferations. As a result of this study, we believe LIP should be abandoned as a pathologic and radiologic diagnosis.<\/jats:p>","DOI":"10.1097\/pas.0000000000002014","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T10:00:17Z","timestamp":1672826417000},"page":"281-295","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":29,"title":["Lymphoid Interstitial Pneumonia (LIP) Revisited"],"prefix":"10.1097","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0833-9549","authenticated-orcid":false,"given":"Christoph","family":"Fraune","sequence":"first","affiliation":[{"name":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Churg","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhee S.","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Khoor","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Kelemen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon T.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen M.","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Gotway","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Ryu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D.","family":"Tazelaar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"R1-20250608","first-page":"277","article-title":"American Thoracic Society\/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. 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