{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T20:40:02Z","timestamp":1749415202764,"version":"3.41.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Penile melanomas (PM) are an exceedingly rare subtype of mucosal melanoma (MM), and we reviewed the clinicopathologic features and molecular profile in 8 PMs. The patient ages ranged from 46 to 78 (mean: 62.8) years with involvement on the glans (n=5; 62.5%), penile urethra (n=2; 25%), and foreskin (n=1, 12.5%). Tumor depth ranged from 1.6 to 10.0 (mean: 5.25) mm. Most of the patients underwent partial penectomy (n=6; 75%) and sentinel lymph node (LN) biopsy N=7; 87.5%). Seven patients had metastatic disease at diagnosis, 6 involving LNs and 1 the adrenal gland, and 4 died of disease with a mean follow-up period of 40.5 (2 to 95) months. Five of 7 (71%) cases identified 15 molecular alterations within <jats:italic toggle=\"yes\">KIT<\/jats:italic>, <jats:italic toggle=\"yes\">CDKN2A<\/jats:italic>, <jats:italic toggle=\"yes\">NF1<\/jats:italic>, <jats:italic toggle=\"yes\">PTEN<\/jats:italic>, and <jats:italic toggle=\"yes\">APC<\/jats:italic> (n=2 each), and <jats:italic toggle=\"yes\">NRAS<\/jats:italic>, <jats:italic toggle=\"yes\">MAP3K1<\/jats:italic>, <jats:italic toggle=\"yes\">CDH1<\/jats:italic>, <jats:italic toggle=\"yes\">MSH6<\/jats:italic>, and <jats:italic toggle=\"yes\">TERT<\/jats:italic> (n=1 each). Two cases were not found to harbor genetic aberrations, and 1 case failed testing. In addition, we reviewed the English literature and included 93 cases with a reported depth of invasion and follow-up. A total of 101 PMs were analyzed for prognostic parameters, and the overall survival was significantly worse in patients with LN metastasis (P=0.0008), distant metastasis (P=0.0016), and greater depth of invasion (P=0.0222) based upon T-stage. While T4 conferred substantially worse survival, the delineation of the survival curves between T2 and T3 was less clear, and combining T2+T3 disease had a strong prognostic impact (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.0024). Prognostic parameters used in the staging of cutaneous melanomas may also be used in PMs. An alternative staging system expanding the inclusion criteria for T2 might provide a more accurate prognostic stratification.<\/jats:p>","DOI":"10.1097\/pas.0000000000002247","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T13:04:34Z","timestamp":1716987874000},"page":"825-833","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological and Molecular Features of Penile Melanoma With a Proposed Staging System"],"prefix":"10.1097","volume":"48","author":[{"given":"Kristine M.","family":"Cornejo","sequence":"first","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Minnesota, Minneapolis, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Valencia Guerrero","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Astudillo","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology Medical Group Inc, Sacramento, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Dias-Santagata","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Atrium Health Pineville, Charlotte, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam S.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Urology, Massachusetts General Hospital, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai P.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"R1-20250608","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G","article-title":"The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. 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