{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:15:56Z","timestamp":1790082956036,"version":"4.0.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Since the original description of\n                    <jats:italic toggle=\"yes\">CRTC1::TRIM11<\/jats:italic>\n                    fusion cutaneous tumors (CTCT) in 2018, an increasing number of cases with metastatic behavior have been reported, yet there are limited studies analyzing prognostic parameters. This expanding data set presents an opportunity for reappraisal of clinical behavior. We present a series of 21 cases with detailed morphologic, molecular, clinical outcomes, and therapeutic response data. We utilize this data and a meta-analysis of all the cases in the literature to assess potential prognostic parameters to assist in clinical management. Primary tumors resulting in metastasis were larger (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.038), had higher mitotic counts (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001), were more frequently ulcerated (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.001), and exclusively harbored\n                    <jats:italic toggle=\"yes\">TERT<\/jats:italic>\n                    promoter mutations (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.005). A functional analysis of mixed data demonstrated a clear clustering pattern in which metastatic cases had larger diameters and were more mitotically active compared with nonmetastatic cases. Inclusion of\n                    <jats:italic toggle=\"yes\">TERT<\/jats:italic>\n                    promoter mutational status further improved the model. There were no metastatic events among cases meeting all the following criteria: size &lt;1.2\u00a0cm, &lt;7 mitoses\/mm\n                    <jats:sup>2<\/jats:sup>\n                    , and absent\n                    <jats:italic toggle=\"yes\">TERT<\/jats:italic>\n                    promoter mutation. Metastatic events frequently involved regional lymph nodes, and all patients with distant metastasis had pulmonary involvement. Considering metastatic events in 23% of cases, sentinel lymph node biopsy and imaging studies may be considered in some cases, while, in cases with smaller size, low mitotic counts, and no evidence of a\n                    <jats:italic toggle=\"yes\">TERT<\/jats:italic>\n                    promoter mutation, excision alone may be adequate. Given poor therapeutic responses in reported metastatic cases, more therapeutic options should be explored.\n                  <\/jats:p>","DOI":"10.1097\/pas.0000000000002575","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:00:08Z","timestamp":1780470008000},"page":"1015-1028","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes and Prognostication of CRTC1::TRIM11 Fusion Cutaneous Tumors"],"prefix":"10.1097","volume":"50","author":[{"given":"Nithya S.","family":"Trichy","sequence":"first","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Braat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay J.","family":"Holic","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantel","family":"Olivares","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus J.","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Service, Memorial Sloan Kettering Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Cheah","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Douglass Hanly Moir Pathology, Macquarie Park"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Cloutier","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Queen Elizabeth Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Dorwal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Monash Health"},{"name":"School of Clinical Sciences, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"de la Fouchardi\u00e8re","sequence":"additional","affiliation":[{"name":"Department de Biopathologie, Centre L\u00e9on B\u00e9rard"},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre L\u00e9on B\u00e9rard, Cancer Research Center of Lyon, Equipe Labellis\u00e9e Ligue contre le Cancer, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, The Johns Hopkins University, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Ieremia","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, John Radcliffe Hospital, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"John","sequence":"additional","affiliation":[{"name":"Departments of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arivarasan","family":"Karunamurthy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh"},{"name":"University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Linos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Service, Memorial Sloan Kettering Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ata S.","family":"Moshiri","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York City, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Salinas","sequence":"additional","affiliation":[{"name":"Servicio de Hemato-Oncolog\u00eda Infantil, Hospital Universitari Son Espases, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Shalin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Campbell","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatopathology, University of Connecticut Health Center, Farmington, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khin","family":"Thway","sequence":"additional","affiliation":[{"name":"Sarcoma Unit, Royal Marsden Hospital"},{"name":"Division 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