{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:06:11Z","timestamp":1789189571456,"version":"build-2803163510"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1097\/pas.0b013e3181cd3aeb","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T02:00:54Z","timestamp":1266890454000},"page":"327-340","source":"Crossref","is-referenced-by-count":314,"title":["B-cell Lymphomas With Concurrent IGH-BCL2 and MYC Rearrangements Are Aggressive Neoplasms With Clinical and Pathologic Features Distinct From Burkitt Lymphoma and Diffuse Large B-cell Lymphoma"],"prefix":"10.1097","volume":"34","author":[{"given":"Matija","family":"Snuderl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga K.","family":"Kolman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie J.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Dal","family":"Cin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Lee","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Hasserjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence R.","family":"Zukerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephraim P.","family":"Hochberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred I.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana E.","family":"Toomey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyah R.","family":"Sohani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210131","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJM199309303291402","article-title":"A Predictive Model for Aggressive Non-Hodgkin's Lymphoma","volume":"329","year":"1993","journal-title":"N Engl J Med"},{"key":"R2-4-20210131","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/leu.2008.281","article-title":"Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of today's knowledge","volume":"23","author":"Boerma","year":"2009","journal-title":"Leukemia"},{"key":"R3-4-20210131","first-page":"83","article-title":"Translocations t(14;18) and t(8;14) with rearranged bcl-2 and c-myc in a case presenting as B-ALL (L3)","volume":"5","author":"Brito-Babapulle","year":"1991","journal-title":"Leukemia"},{"key":"R4-4-20210131","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1365-2141.2006.06194.x","article-title":"Diagnosis of Burkitt lymphoma in due time: a practical approach","volume":"134","author":"Cogliatti","year":"2006","journal-title":"Br J Haematol"},{"key":"R5-4-20210131","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/biomet\/62.2.269","article-title":"Partial likelihood","volume":"62","author":"Cox","year":"1975","journal-title":"Biometrika"},{"key":"R6-4-20210131","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cancergencyto.2006.07.005","article-title":"Translocation (14;18) (q32;q21) in acute lymphoblastic leukemia: a study of 12 cases and review of the literature","volume":"171","author":"D'Achille","year":"2006","journal-title":"Cancer Genet Cytogenet"},{"key":"R7-4-20210131","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa055759","article-title":"Molecular diagnosis of Burkitt's lymphoma","volume":"354","author":"Dave","year":"2006","journal-title":"N Engl J Med"},{"key":"R8-4-20210131","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1056\/NEJM198805263182106","article-title":"Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma","volume":"318","author":"De Jong","year":"1988","journal-title":"N Engl J Med"},{"key":"R9-4-20210131","doi-asserted-by":"crossref","first-page":"610","DOI":"10.5858\/2003-127-0610-MBALLW","article-title":"Mature B-cell acute lymphoblastic leukemia with associated translocations (14;18)(q32;q21) and (8;9)(q24;p13). A Burkitt variant?","volume":"127","author":"Dunphy","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"R10-4-20210131","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/BF01698379","article-title":"Translocation (14;18) and (8;22) in three patients with acute leukemia\/lymphoma following centrocytic\/centroblastic non-Hodgkin's lymphoma","volume":"63","author":"Fiedler","year":"1991","journal-title":"Ann Hematol"},{"key":"R11-4-20210131","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1038\/sj.leu.2403954","article-title":"Translocation t(14;18) and gain of chromosome 18\/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas","volume":"19","author":"Galteland","year":"2005","journal-title":"Leukemia"},{"key":"R12-4-20210131","first-page":"431","article-title":"Pre-B-cell leukemia with a t(8;14) and a t(14;18) translocation is preceded by follicular lymphoma","volume":"2","author":"Gauwerky","year":"1988","journal-title":"Oncogene"},{"key":"R13-4-20210131","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/ajcp\/85.5.636","article-title":"Acute lymphoblastic leukemia of Burkitt's type (L3 ALL) with 8;22 and 14;18 translocations and absent surface immunoglobulins","volume":"85","author":"Gluck","year":"1986","journal-title":"Am J Clin Pathol"},{"key":"R14-4-20210131","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"R15-4-20210131","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1097\/01.pas.0000168176.71405.e5","article-title":"Clinical, immunophenotypic, and genetic analysis of adult lymphomas with morphologic features of Burkitt lymphoma","volume":"29","author":"Haralambieva","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"R16-4-20210131","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/ajcp\/103.4.472","article-title":"Comparison of cytogenetic analysis, southern analysis, and polymerase chain reaction for the detection of t(14;18) in follicular lymphoma","volume":"103","author":"Horsman","year":"1995","journal-title":"Am J Clin Pathol"},{"key":"R17-4-20210131","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa055351","article-title":"A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling","volume":"354","author":"Hummel","year":"2006","journal-title":"N Engl J Med"},{"key":"R18-4-20210131","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood-2009-03-212191","article-title":"Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival","volume":"114","author":"Johnson","year":"2009","journal-title":"Blood"},{"key":"R19-4-20210131","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/modpathol.3800500","article-title":"Lymphoid neoplasms associated with concurrent t(14;18) and 8q24\/c-MYC translocation generally have a poor prognosis","volume":"19","author":"Kanungo","year":"2006","journal-title":"Mod Pathol"},{"key":"R20-4-20210131","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1532\/IJH97.03105","article-title":"Case of B-cell lymphoma with rearrangement of the BCL1, BCL2, BCL6, and c-MYC genes","volume":"79","author":"Kawakami","year":"2004","journal-title":"Int J Hematol"},{"key":"R21-4-20210131","first-page":"265","article-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Kluin","year":"2008"},{"key":"R22-4-20210131","first-page":"145","article-title":"Molecular structure of double reciprocal translocations: significance in B-cell lymphomagenesis","volume":"6","author":"Koduru","year":"1991","journal-title":"Oncogene"},{"key":"R23-4-20210131","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/hon.2900090202","article-title":"Chromosomal abnormalities in adult non-endemic Burkitt's lymphoma and leukemia: 22 new reports and a review of 148 cases from the literature","volume":"9","author":"Kornblau","year":"1991","journal-title":"Hematol Oncol"},{"key":"R24-4-20210131","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1182\/blood.V92.9.3152","article-title":"Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma","volume":"92","author":"Kramer","year":"1998","journal-title":"Blood"},{"key":"R25-4-20210131","first-page":"473","article-title":"De novo acute B-cell leukemia with translocation t(14;18): an entity with a poor prognosis","volume":"5","author":"Kramer","year":"1991","journal-title":"Leukemia"},{"key":"R26-4-20210131","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3324\/haematol.11305","article-title":"The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24\/c-MYC rearrangement","volume":"92","author":"Le","year":"2007","journal-title":"Haematologica"},{"key":"R27-4-20210131","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1172\/JCI114320","article-title":"Sequential bcl-2 and c-myc oncogene rearrangements associated with the clinical transformation of non-Hodgkin's lymphoma","volume":"84","author":"Lee","year":"1989","journal-title":"J Clin Invest"},{"key":"R28-4-20210131","first-page":"262","article-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Leoncini","year":"2008"},{"key":"R29-4-20210131","first-page":"560","article-title":"The t(14;18) in a patient with de novo acute lymphoblastic leukemia is associated with t(8;9)","volume":"8","author":"Lillington","year":"1994","journal-title":"Leukemia"},{"key":"R30-4-20210131","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3324\/haematol.11263","article-title":"High-grade B-cell lymphoma\/leukemia associated with t(14;18) and 8q24\/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis","volume":"92","author":"Lin","year":"2007","journal-title":"Haematologica"},{"key":"R31-4-20210131","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1200\/JCO.1999.17.5.1558","article-title":"Small noncleaved, non-Burkitt's (Burkitt-like) lymphoma: cytogenetics predict outcome and reflect clinical presentation","volume":"17","author":"Macpherson","year":"1999","journal-title":"J Clin Oncol"},{"key":"R32-4-20210131","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01715354","article-title":"Simultaneous occurrence of t(14;18) and t(8;22) common acute lymphoblastic leukemia","volume":"64","author":"Marosi","year":"1992","journal-title":"Ann Hematol"},{"key":"R33-4-20210131","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/gcc.20187","article-title":"Amplification of IGH\/MYC fusion in clinically aggressive IGH\/BCL2-positive germinal center B-cell lymphomas","volume":"43","author":"Martin-Subero","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"R34-4-20210131","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1365-2141.2008.07528.x","article-title":"BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations","volume":"144","author":"Masir","year":"2009","journal-title":"Br J Haematol"},{"key":"R35-4-20210131","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1136\/jcp.2006.043034","article-title":"Follicular lymphoma with trisomy 18 exhibiting loss of BCL-2 expression on transformation to a large cell lymphoma","volume":"60","author":"Masir","year":"2007","journal-title":"J Clin Pathol"},{"key":"R36-4-20210131","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1097\/01.pas.0000180442.87022.08","article-title":"Adult B-cell lymphomas with Burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior","volume":"29","author":"McClure","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"R37-4-20210131","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1182\/blood-2008-03-145128","article-title":"A prospective clinicopathologic study of dose-modified CODOX-M\/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC\/NCRI LY10 trial)","volume":"112","author":"Mead","year":"2008","journal-title":"Blood"},{"key":"R38-4-20210131","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-4608(00)00383-6","article-title":"Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic\/blastoid variant","volume":"126","author":"Mohamed","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"R39-4-20210131","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1182\/blood.V62.5.1142.1142","article-title":"Common ALL with pre-B-cell features showing (8;14) and (14;18) chromosome translocations","volume":"62","author":"Mufti","year":"1983","journal-title":"Blood"},{"key":"R40-4-20210131","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.humpath.2005.01.004","article-title":"Transformation of follicular lymphoma to Burkitt-like lymphoma within a single lymph node","volume":"36","author":"Mukhopadhyay","year":"2005","journal-title":"Hum Pathol"},{"key":"R41-4-20210131","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00000478-200004000-00006","article-title":"Blastic\/blastoid transformation of follicular lymphoma: immunohistologic and molecular analyses of five cases","volume":"24","author":"Natkunam","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"R42-4-20210131","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/leu.2008.344","article-title":"Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24\/c-MYC translocations","volume":"23","author":"Niitsu","year":"2009","journal-title":"Leukemia"},{"key":"R43-4-20210131","doi-asserted-by":"crossref","first-page":"7166","DOI":"10.1073\/pnas.81.22.7166","article-title":"A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia","volume":"81","author":"Pegoraro","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"R44-4-20210131","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1097\/PAS.0b013e31817d7452","article-title":"CD20+ T-cell lymphoma: clinicopathologic analysis of 9 cases and a review of the literature","volume":"32","author":"Rahemtullah","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"R45-4-20210131","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3324\/haematol.13071","article-title":"Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma","volume":"93","author":"Salaverria","year":"2008","journal-title":"Haematologica"},{"key":"R46-4-20210131","article-title":"An International System fot Human Cytogenetic Nomenclature","author":"Shaffer","year":"2005"},{"key":"R47-4-20210131","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1038\/sj.leu.2401910","article-title":"De novo acute B cell leukemia\/lymphoma with t(14;18)","volume":"14","author":"Stamatoullas","year":"2000","journal-title":"Leukemia"},{"key":"R48-4-20210131","article-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2008"},{"key":"R49-4-20210131","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/gcc.2870020211","article-title":"Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11)","volume":"2","author":"Thangavelu","year":"1990","journal-title":"Genes Chromosomes Cancer"},{"key":"R50-4-20210131","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/01.pas.0000146027.76706.50","article-title":"Atypical Burkitt lymphoma arising from follicular lymphoma: demonstration by polymerase chain reaction following laser capture microdissection and by fluorescence in situ hybridization on paraffin-embedded tissue sections","volume":"29","author":"Tomita","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"R51-4-20210131","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3324\/haematol.2008.005355","article-title":"Clinicopathological features of lymphoma\/leukemia patients carrying both BCL2 and MYC translocations","volume":"94","author":"Tomita","year":"2009","journal-title":"Haematologica"},{"key":"R52-4-20210131","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0165-4608(94)90003-5","article-title":"A new B-cell line showing a complex translocation (8;14;18) and BCL2 rearrangement","volume":"74","author":"van Ooteghem","year":"1994","journal-title":"Cancer Genet Cytogenet"},{"key":"R53-4-20210131","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1008201729596","article-title":"Rearrangements of bcl-6, bcl-2, c-myc and 6q deletion in B-diffuse large-cell lymphoma: clinical relevance in 71 patients","volume":"9","author":"Vitolo","year":"1998","journal-title":"Ann Oncol"},{"key":"R54-4-20210131","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5858\/2004-128-210-FLWABT","article-title":"Follicular lymphoma with a Burkitt translocation--predictor of an aggressive clinical course: a case report and review of the literature","volume":"128","author":"Voorhees","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"R55-4-20210131","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1097\/01.pas.0000172191.87176.3b","article-title":"Low histologic grade follicular lymphoma with high proliferation index: morphologic and clinical features","volume":"29","author":"Wang","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"R56-4-20210131","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1056\/NEJM198711053171904","article-title":"Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas","volume":"317","author":"Weiss","year":"1987","journal-title":"N Engl J Med"},{"key":"R58-4-20210131","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0165-4608(00)00301-0","article-title":"Follicular lymphoma with trisomy 18 and over-expression of BCL2 in the absence of t(14;18)(q32;q21)","volume":"123","author":"Wong","year":"2000","journal-title":"Cancer Genet Cytogenet"},{"key":"R59-4-20210131","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1309\/NKK3FEX2BE5L7EKB","article-title":"Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event","volume":"129","author":"Young","year":"2008","journal-title":"Am J Clin Pathol"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000478-201003000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:19:31Z","timestamp":1786040371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000478-201003000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0b013e3181cd3aeb","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}