{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:03:23Z","timestamp":1792098203501,"version":"4.4.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1097\/pas.0b013e3181cf3d79","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T02:00:54Z","timestamp":1266890454000},"page":"433-443","source":"Crossref","is-referenced-by-count":1532,"title":["The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory"],"prefix":"10.1097","volume":"34","author":[{"given":"Robert J.","family":"Kurman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie-Ming","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20210131","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1471-2407-9-111","article-title":"KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay","volume":"9","author":"Auner","year":"2009","journal-title":"BMC Cancer"},{"key":"R2-18-20210131","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/1097-0142(19940401)73:7<1859::AID-CNCR2820730714>3.0.CO;2-L","article-title":"Early de novo ovarian carcinoma. A study of fourteen cases","volume":"73","author":"Bell","year":"1994","journal-title":"Cancer"},{"key":"R3-18-20210131","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N Engl J Med"},{"key":"R4-18-20210131","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1200\/JCO.2007.12.2622","article-title":"Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction","volume":"25","author":"Callahan","year":"2007","journal-title":"J Clin Oncol"},{"key":"R5-18-20210131","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/01.pgp.0000101082.35393.84","article-title":"Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers","volume":"23","author":"Carcangiu","year":"2004","journal-title":"Int J Gynecol Pathol"},{"key":"R6-18-20210131","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nm1230","article-title":"Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract","volume":"11","author":"Cheng","year":"2005","journal-title":"Nat Med"},{"key":"R7-18-20210131","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.pathol.4.110807.092246","article-title":"Ovarian cancer","volume":"4","author":"Cho","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"R8-18-20210131","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1097\/00000478-200110000-00009","article-title":"Occult carcinoma in prophylactic oophorectomy specimens: prevalence and association with BRCA germline mutation status","volume":"25","author":"Colgan","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"R9-18-20210131","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/PAS.0b013e31802cbbe9","article-title":"The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis","volume":"31","author":"Dehari","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"R10-18-20210131","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/(SICI)1097-0142(19991015)86:8<1544::AID-CNCR22>3.0.CO;2-I","article-title":"Ovarian dysplasia in prophylactic oophorectomy specimens: cytogenetic and morphometric correlations","volume":"86","author":"Deligdisch","year":"1999","journal-title":"Cancer"},{"key":"R11-18-20210131","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S1470-2045(08)70308-5","article-title":"The cell of origin of ovarian epithelial tumours","volume":"9","author":"Dubeau","year":"2008","journal-title":"Lancet Oncol"},{"key":"R12-18-20210131","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ygyno.2005.06.065","article-title":"Clinical and pathologic findings of prophylactic salpingo-oophorectomies in 159 BRCA1 and BRCA2 carriers","volume":"100","author":"Finch","year":"2006","journal-title":"Gynecol Oncol"},{"key":"R13-18-20210131","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ygyno.2009.01.013","article-title":"Precursors to pelvic serous carcinoma and their clinical implications","volume":"113","author":"Folkins","year":"2009","journal-title":"Gynecol Oncol"},{"key":"R14-18-20210131","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ygyno.2004.11.053","article-title":"Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma","volume":"97","author":"Gagner","year":"2005","journal-title":"Gynecol Oncol"},{"key":"R15-18-20210131","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/humrep\/13.6.1425","article-title":"Endoscopic visualization of the process of fimbrial ovum retrieval in the human","volume":"13","author":"Gordts","year":"1998","journal-title":"Hum Reprod"},{"key":"R16-18-20210131","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/cncr.22919","article-title":"Metastatic patterns at autopsy in patients with ovarian carcinoma","volume":"110","author":"Guth","year":"2007","journal-title":"Cancer"},{"key":"R17-18-20210131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/pgp.0b013e31814b191f","article-title":"Serous carcinogenesis in the fallopian tube: a descriptive classification","volume":"27","author":"Jarboe","year":"2008","journal-title":"Int J Gynecol Pathol"},{"key":"R18-18-20210131","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3322\/caac.20006","article-title":"Cancer statistics, 2009","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J Clin"},{"key":"R19-18-20210131","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship","volume":"31","author":"Kindelberger","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"R20-18-20210131","doi-asserted-by":"crossref","DOI":"10.7208\/chicago\/9780226458106.001.0001","article-title":"The Structure of Scientific Revolutions","author":"Kuhn","year":"1996"},{"key":"R21-18-20210131","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1158\/0008-5472.CAN-08-3913","article-title":"Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas","volume":"69","author":"Kuo","year":"2009","journal-title":"Cancer Res"},{"key":"R22-18-20210131","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.2353\/ajpath.2009.081000","article-title":"Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma","volume":"174","author":"Kuo","year":"2009","journal-title":"Am J Pathol"},{"key":"R23-18-20210131","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00006254-197203000-00001","article-title":"The secondary Mullerian system","volume":"27","author":"Lauchlan","year":"1972","journal-title":"Obstet Gynecol Surv"},{"key":"R24-18-20210131","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube","volume":"211","author":"Lee","year":"2007","journal-title":"J Pathol"},{"key":"R25-18-20210131","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1158\/1078-0432.CCR-04-2509","article-title":"Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon","volume":"11","author":"Marquez","year":"2005","journal-title":"Clin Cancer Res"},{"key":"R26-18-20210131","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-2008-1068762","article-title":"Cancer and endometriosis: do we need to be concerned?","volume":"15","author":"Martin","year":"1997","journal-title":"Semin Reprod Endocrinol"},{"key":"R27-18-20210131","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Medeiros","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"R28-18-20210131","first-page":"1489","article-title":"Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy","volume":"53","author":"Mok","year":"1993","journal-title":"Cancer Res"},{"key":"R29-18-20210131","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/gyno.2000.6071","article-title":"Occult cancer of the fallopian tube in BRCA-1 germline mutation carriers at prophylactic oophorectomy: a case for recommending hysterectomy at surgical prophylaxis","volume":"80","author":"Paley","year":"2001","journal-title":"Gynecol Oncol"},{"key":"R30-18-20210131","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/AOG.0b013e3181a11c64","article-title":"Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study","volume":"113","author":"Parker","year":"2009","journal-title":"Obstet Gynecol"},{"key":"R31-18-20210131","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/AOG.0b013e31819cda77","article-title":"Results from four rounds of ovarian cancer screening in a randomized trial","volume":"113","author":"Partridge","year":"2009","journal-title":"Obstet Gynecol"},{"key":"R32-18-20210131","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-1-60327-492-0_20","article-title":"Epidemiology of ovarian cancer","volume":"472","author":"Permuth-Wey","year":"2009","journal-title":"Methods Mol Biol"},{"key":"R33-18-20210131","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J Pathol"},{"key":"R34-18-20210131","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0140-6736(01)05992-X","article-title":"Tubal ligation and risk of ovarian cancer","volume":"358","author":"Piek","year":"2001","journal-title":"Lancet"},{"key":"R35-18-20210131","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0090-8258(03)00365-2","article-title":"BRCA1\/2-related ovarian cancers are of tubal origin: a hypothesis","volume":"90","author":"Piek","year":"2003","journal-title":"Gynecol Oncol"},{"key":"R36-18-20210131","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/oxfordjournals.aje.a113523","article-title":"Events of reproductive life and the incidence of epithelial ovarian cancer","volume":"117","author":"Risch","year":"1983","journal-title":"Am J Epidemiol"},{"key":"R37-18-20210131","first-page":"933","article-title":"Reduced risk of ovarian cancer in women with a tubal ligation or hysterectomy. The World Health Organization Collaborative Study of Neoplasia and Steroid Contraceptives","volume":"5","author":"Rosenblatt","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R38-18-20210131","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/IGC.0b013e318199009c","article-title":"The fallopian tube: primary site of most pelvic high-grade serous carcinomas","volume":"19","author":"Salvador","year":"2009","journal-title":"Int J Gynecol Cancer"},{"key":"R39-18-20210131","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00006254-196104000-00022","article-title":"Primary carcinoma of the fallopian tube","volume":"16","author":"Sedlis","year":"1961","journal-title":"Obstet Gynecol Surv"},{"key":"R40-18-20210131","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.5858\/132.11.1753","article-title":"Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: a study of 120 tumors","volume":"132","author":"Seidman","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"R41-18-20210131","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/modpathol.2009.89","article-title":"Candidate serous cancer precursors in fallopian tube epithelium of BRCA1\/2 mutation carriers","volume":"22","author":"Shaw","year":"2009","journal-title":"Mod Pathol"},{"key":"R42-18-20210131","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00004347-199904000-00009","article-title":"Histopathologic features of ovaries at increased risk for carcinoma. A case-control analysis","volume":"18","author":"Sherman","year":"1999","journal-title":"Int J Gynecol Pathol"},{"key":"R43-18-20210131","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0002-9440(10)63708-X","article-title":"Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis","volume":"164","author":"Shih","year":"2004","journal-title":"Am J Pathol"},{"key":"R44-18-20210131","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/PAS.0b013e31819c4271","article-title":"Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases","volume":"33","author":"Veras","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"R45-18-20210131","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/00000478-200006000-00004","article-title":"Minimal uterine serous carcinoma: diagnosis and clinicopathologic correlation","volume":"24","author":"Wheeler","year":"2000","journal-title":"Am J Surg Pathol"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000478-201003000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:19:20Z","timestamp":1786040360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000478-201003000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0b013e3181cf3d79","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.2181957.1792055","asserted-by":"object"}]},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}