{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:10:23Z","timestamp":1788239423107,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1097\/pas.0b013e31822a5a2c","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T18:32:38Z","timestamp":1317753158000},"page":"1-7","source":"Crossref","is-referenced-by-count":74,"title":["Columnar-Lined Esophagus Without Intestinal Metaplasia Has No Proven Risk of Adenocarcinoma"],"prefix":"10.1097","volume":"36","author":[{"given":"Parakrama","family":"Chandrasoma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulochana","family":"Wijetunge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"DeMeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Zamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"DeMeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20210131","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/thx.8.2.87","article-title":"The oesophagus lined with gastric mucous membrane.","volume":"8","author":"Allison","year":"1953","journal-title":"Thorax"},{"key":"R2-2-20210131","first-page":"881","article-title":"The lower esophagus lined by columnar epithelium.","volume":"41","author":"Barrett","year":"1957","journal-title":"Surgery"},{"key":"R4-2-20210131","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/0016-5085(95)90642-8","article-title":"Adenocarcinoma of the esophago-gastric junction and Barretts esophagus.","volume":"109","author":"Cameron","year":"1995","journal-title":"Gastroenterology"},{"key":"R5-2-20210131","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2559.2005.02088.x","article-title":"Controversies of the cardiac mucosa and Barretts esophagus.","volume":"46","author":"Chandrasoma","year":"2005","journal-title":"Histopathol"},{"key":"R6-2-20210131","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/00000478-200109000-00010","article-title":"Distribution and significance of epithelial types in columnar lined esophagus.","volume":"25","author":"Chandrasoma","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"R7-2-20210131","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/00000478-200307000-00008","article-title":"Histologic classification of patients based on mapping biopsies of the gastroesophageal junction.","volume":"27","author":"Chandrasoma","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"R9-2-20210131","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1097\/PAS.0b013e3181f06990","article-title":"The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux disease.","volume":"34","author":"Chandrasoma","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"R10-2-20210131","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1053\/gast.2002.31879","article-title":"Surveillance and survival in Barretts adenocarcinomas: a population-based study.","volume":"122","author":"Corley","year":"2002","journal-title":"Gastroenterology"},{"key":"R11-2-20210131","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2","article-title":"Changing patterns in the incidence of esophageal and gastric carcinoma in the United States.","volume":"83","author":"Devesa","year":"1998","journal-title":"Cancer"},{"key":"R13-2-20210131","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/00365520701879831","article-title":"Relevance of the detection of intestinal metaplasia in non-dysplastic columnar-lined oesophagus.","volume":"43","author":"Gatenby","year":"2008","journal-title":"Scand J Gastroenterol"},{"key":"R15-2-20210131","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/thx.16.1.36","article-title":"The lower end of the oesophagus.","volume":"16","author":"Hayward","year":"1961","journal-title":"Thorax"},{"key":"R16-2-20210131","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1080\/00365520701420735","article-title":"Barretts oesophagus: intestinal metaplasia is not essential for cancer risk.","volume":"42","author":"Kelty","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"R17-2-20210131","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ajg.2009.85","article-title":"Metaplastic esophageal columnar epithelium without goblet cells shows DNA content abnormalities similar to goblet cell-containing epithelium.","volume":"104","author":"Liu","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"R18-2-20210131","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/bmj.327.7414.534","article-title":"Risk of adenocarcinoma in Barretts oesophagus: population-based study.","volume":"327","author":"Murray","year":"2003","journal-title":"Brit Med J"},{"key":"R19-2-20210131","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00000478-199502000-00007","article-title":"Surgical pathology of adenocarcinoma arising in Barretts esophagus: analysis of 67 cases.","volume":"19","author":"Paraf","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"R20-2-20210131","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJM197608262950904","article-title":"The histologic spectrum of Barretts esophagus.","volume":"295","author":"Paull","year":"1976","journal-title":"N Eng J Med"},{"key":"R21-2-20210131","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0022-5223(94)70178-4","article-title":"Outcome of adenocarcinoma arising in Barretts esophagus in endoscopically surveyed and nonsurveyed patients.","volume":"108","author":"Peters","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R22-2-20210131","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/SLA.0b013e318188c474","article-title":"The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection.","volume":"248","author":"Peyre","year":"2008","journal-title":"Ann Surg"},{"key":"R23-2-20210131","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/jnci\/dji024","article-title":"The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence.","volume":"97","author":"Pohl","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"R24-2-20210131","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1053\/j.gastro.2003.09.030","article-title":"Screening for Barretts esophagus in colonoscopy patients with and without heartburn.","volume":"125","author":"Rex","year":"2003","journal-title":"Gastroenterology"},{"key":"R26-2-20210131","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1053\/j.gastro.2005.08.053","article-title":"Prevalence of Barretts esophagus in the general population: an endoscopic study.","volume":"129","author":"Ronkainen","year":"2005","journal-title":"Gastroenterology"},{"key":"R27-2-20210131","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/1097-0142(19850315)55:6<1353::AID-CNCR2820550632>3.0.CO;2-D","article-title":"Analysis of adenocarcinoma in Barretts esophagus utilizing a staging system.","volume":"55","author":"Rosenberg","year":"1985","journal-title":"Cancer"},{"key":"R28-2-20210131","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1002\/1097-0142(20000601)88:11<2520::AID-CNCR13>3.0.CO;2-L","article-title":"Intestinal metaplasia is the probable common precursor of adenocarcinoma in Barrett esophagus and adenocarcinoma of the gastric cardia.","volume":"88","author":"Ruol","year":"2000","journal-title":"Cancer"},{"key":"R29-2-20210131","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00000658-198310000-00016","article-title":"Barretts esophagus: comparison of benign and malignant cases.","volume":"198","author":"Skinner","year":"1983","journal-title":"Ann Surg"},{"key":"R30-2-20210131","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1053\/j.gastro.2011.01.031","article-title":"American Gastroenterological Association Medical Position Statement on the Management of Barretts esophagus.","volume":"140","author":"Spechler","year":"2011","journal-title":"Gastroenterology"},{"key":"R31-2-20210131","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.humpath.2008.06.008","article-title":"Cardiac rather than intestinal-type background in endoscopic mucosal resection specimens of minute Barrett adenocarcinoma.","volume":"40","author":"Takubo","year":"2009","journal-title":"Hum Pathol"},{"key":"R32-2-20210131","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00464-005-0255-x","article-title":"Predictive factors of coexisting cancer in Barretts high grade dysplasia.","volume":"20","author":"Tharavej","year":"2006","journal-title":"Surg Endosc"},{"key":"R33-2-20210131","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00464-001-8307-3","article-title":"Preoperative chemotherapy unmasks underlying Barretts mucosa in patients with adenocarcinoma of the distal esophagus.","volume":"16","author":"Theisen","year":"2002","journal-title":"Surg Endosc"},{"key":"R34-2-20210131","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1002\/1097-0142(20000601)88:11<2429::AID-CNCR1>3.0.CO;2-H","article-title":"Pathology of early invasive adenocarcinoma of the esophagus or esophagogastric junction: implications for therapeutic decision making.","volume":"88","author":"van Sandyck","year":"2000","journal-title":"Cancer"},{"key":"R35-2-20210131","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/PAS.0b013e3181eff133","article-title":"Association of adenocarcinomas of the distal esophagus, gastroesophageal junction and gastric cardia with gastric pathology.","volume":"34","author":"Wijetunge","year":"2010","journal-title":"Am J Surg Pathol"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000478-201201000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:29:45Z","timestamp":1786048185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000478-201201000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0b013e31822a5a2c","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}