{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:40:59Z","timestamp":1787766059075,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1097\/pas.0b013e318236c312","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T06:02:54Z","timestamp":1320386574000},"page":"351-359","source":"Crossref","is-referenced-by-count":80,"title":["Prox1 Transcription Factor as a Marker for Vascular Tumors\u2014Evaluation of 314 Vascular Endothelial and 1086 Nonvascular Tumors"],"prefix":"10.1097","volume":"36","author":[{"given":"Markku","family":"Miettinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210131","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1600-0560.2006.00461.x","article-title":"Usefulness of D2-40 immunohisto-chemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma.","volume":"33","author":"Arai","year":"2006","journal-title":"J Cutan Pathol"},{"key":"R2-4-20210131","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0002-9440(10)65285-6","article-title":"Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium.","volume":"154","author":"Breiteneder-Geleff","year":"1999","journal-title":"Am J Pathol"},{"key":"R3-4-20210131","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0925-4773(02)00240-X","article-title":"Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm.","volume":"118","author":"Burke","year":"2002","journal-title":"Mech Dev"},{"key":"R4-4-20210131","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1038\/jid.2008.176","article-title":"Prox-1 promotes invasion of kaposiform hemangioendotheliomas.","volume":"128","author":"Dadras","year":"2008","journal-title":"J Invest Dermatol"},{"key":"R5-4-20210131","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00429-004-0403-4","article-title":"The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium.","volume":"208","author":"Dudas","year":"2004","journal-title":"Anat Embryol (Berl)"},{"key":"R6-4-20210131","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00418-006-0191-4","article-title":"Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from oval cells.","volume":"126","author":"Dudas","year":"2006","journal-title":"Histochem Cell Biol"},{"key":"R7-4-20210131","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/00000478-199909000-00002","article-title":"Papillary intralymphatic angio-endothelioma (PILA): a report of 12 cases of a distinctive vascular tumor with phenotypic features of lymphatic vessels.","volume":"23","author":"Fanburg-Smith","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"R8-4-20210131","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ng1642","article-title":"Lymphatic vascular defects promoted by Prox1 haploinsufficiency caused adult-onset obesity.","volume":"37","author":"Harvey","year":"2005","journal-title":"Nat Genet"},{"key":"R9-4-20210131","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0002-9440(10)63851-5","article-title":"Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells.","volume":"162","author":"Hirakawa","year":"2003","journal-title":"Am J Pathol"},{"key":"R10-4-20210131","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00441-003-0747-8","article-title":"Prox1, master regulator of the lymphatic vasculature phenotype.","volume":"314","author":"Hong","year":"2003","journal-title":"Cell Tissue Res"},{"key":"R11-4-20210131","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ng1383","article-title":"Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.","volume":"36","author":"Hong","year":"2004","journal-title":"Nat Genet"},{"key":"R12-4-20210131","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1101\/gad.1727208","article-title":"Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.","volume":"22","author":"Johnson","year":"2008","journal-title":"Genes Dev"},{"key":"R13-4-20210131","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/modpathol.3880543","article-title":"Monoclonal antibody D2-40 a new marker of lymphatic endothelium, reacts with Kaposis sarcoma and a subset of angiosarcomas.","volume":"15","author":"Kahn","year":"2002","journal-title":"Mod Pathol"},{"key":"R14-4-20210131","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/PAP.0b013e3181915e94","article-title":"D2-40 immunohistochemistryso far.","volume":"16","author":"Kalof","year":"2009","journal-title":"Adv Anat Pathol"},{"key":"R15-4-20210131","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jhep.2006.07.033","article-title":"Prospero-related homeobox 1 (PROX1) is frequently inactivated by genetic deletions and epigenetic silencing in carcinomas of the biliary system.","volume":"46","author":"Laerm","year":"2007","journal-title":"J Hepatol"},{"key":"R16-4-20210131","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1097\/PAS.0b013e3181f6076f","article-title":"Expression of Prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma.","volume":"34","author":"Le Huu","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"R17-4-20210131","first-page":"495","article-title":"Vascular anomaliesclassification, diagnosis, and natural history. Review.","volume":"9","author":"Marler","year":"2001","journal-title":"Facial Plast Surg Clin North Am"},{"key":"R18-4-20210131","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00292-001-0498-9","article-title":"Tumors of the lymphatic vessels of the skin and soft tissue.","volume":"23","author":"Mentzel","year":"2002","journal-title":"Pathologe"},{"key":"R19-4-20210131","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/PAS.0b013e318206b67b","article-title":"ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma.","volume":"35","author":"Miettinen","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"R21-4-20210131","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1091\/mbc.e06-09-0780","article-title":"Prox1 induces lymphatic endothelial differentiation via integrin alpha-9 and other signaling cascades.","volume":"18","author":"Mishima","year":"2007","journal-title":"Mol Biol Cell"},{"key":"R22-4-20210131","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/modpathol.3800537","article-title":"Infantile hemangioma is a proliferation of LYVE-1 negative blood endothelial cells without lymphatic competence.","volume":"19","author":"Nguyen","year":"2006","journal-title":"Mod Pathol"},{"key":"R23-4-20210131","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1002\/(SICI)1097-0142(19991201)86:11<2406::AID-CNCR31>3.0.CO;2-E","article-title":"Lack of lymphatic vascular specificity of vascular endothelial growth factor 3 in 185 vascular tumors.","volume":"86","author":"Partanen","year":"1999","journal-title":"Cancer"},{"key":"R24-4-20210131","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1097\/00000478-199610000-00004","article-title":"Spindle cell hemangioendothelioma: an analysis of 78 cases with reassessment of its pathogenesis and biologic behavior.","volume":"20","author":"Perkins","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"R25-4-20210131","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ccr.2008.02.020","article-title":"Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.","volume":"13","author":"Petrova","year":"2008","journal-title":"Cancer Cell"},{"key":"R26-4-20210131","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1242\/dev.030007","article-title":"Prox1 maintains muscle structure and growth in the developing heart.","volume":"136","author":"Riseboro","year":"2009","journal-title":"Development"},{"key":"R27-4-20210131","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/ajcp\/96.1.25","article-title":"The human hematopoietic progenitor cell antigen (CD34) in vascular neoplasia.","volume":"96","author":"Traweek","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"R28-4-20210131","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ijc.22705","article-title":"Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer.","volume":"121","author":"Versmold","year":"2007","journal-title":"Int J Cancer"},{"key":"R29-4-20210131","first-page":"243","article-title":"Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposis sarcoma tumor cells.","volume":"79","author":"Weninger","year":"1999","journal-title":"Lab Invest"},{"key":"R30-4-20210131","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/emboj\/21.7.1505","article-title":"An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.","volume":"7","author":"Wigle","year":"2002","journal-title":"EMBO J"},{"key":"R31-4-20210131","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1096\/fj.01-1010fje","article-title":"The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues.","volume":"16","author":"Wilting","year":"2002","journal-title":"FASEB J"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000478-201203000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:30:11Z","timestamp":1786048211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000478-201203000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0b013e318236c312","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}