{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:27:58Z","timestamp":1774592878611,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1097\/pas.0b013e3182583678","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T12:51:01Z","timestamp":1340887861000},"page":"1036-1046","source":"Crossref","is-referenced-by-count":44,"title":["Tumor Cell Anaplasia and Multinucleation Are Predictors of Disease Recurrence in Oropharyngeal Squamous Cell Carcinoma, Including Among Just the Human Papillomavirus-Related Cancers"],"prefix":"10.1097","volume":"36","author":[{"given":"James S.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette B.","family":"Scantlebury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingqin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wade L.","family":"Thorstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-13-20210131","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hed.21269","article-title":"Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, DC.","volume":"31","author":"Adelstein","year":"2009","journal-title":"Head Neck"},{"key":"R2-13-20210131","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11912-010-0084-5","article-title":"Human papillomavirus: changing paradigms in oropharyngeal cancer.","volume":"12","author":"Adelstein","year":"2010","journal-title":"Curr Oncol Rep"},{"key":"R3-13-20210131","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1126\/science.1206923","article-title":"Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.","volume":"333","author":"Agrawal","year":"2011","journal-title":"Science"},{"key":"R4-13-20210131","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer.","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"R5-13-20210131","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.humpath.2011.02.004","article-title":"PAX8 immunostaining of anaplastic thyroid carcinoma: a reliable means of discerning thyroid origin for undifferentiated tumors of the head and neck.","volume":"42","author":"Bishop","year":"2011","journal-title":"Hum Pathol"},{"key":"R6-13-20210131","doi-asserted-by":"crossref","first-page":"138469","DOI":"10.4061\/2011\/138469","article-title":"Ancillary studies in determining human papillomavirus status of squamous cell carcinoma of the oropharynx: a review.","volume":"2011","author":"Cantley","year":"2011","journal-title":"Pathol Res Int"},{"key":"R7-13-20210131","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12105-009-0126-1","article-title":"HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome.","volume":"3","author":"Chernock","year":"2009","journal-title":"Head Neck Pathol"},{"key":"R8-13-20210131","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0030-4220(80)90436-3","article-title":"Spindle cell carcinoma of the oral cavity. A clinicopathologic assessment of fifty-nine cases.","volume":"50","author":"Ellis","year":"1980","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R9-13-20210131","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hed.21440","article-title":"Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis.","volume":"33","author":"Fischer","year":"2011","journal-title":"Head Neck"},{"key":"R11-13-20210131","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5858\/2008-0547-RAR.1","article-title":"Sarcomatoid carcinoma of the lung: histologic criteria and common lesions in the differential diagnosis.","volume":"134","author":"Franks","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"R12-13-20210131","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1002\/ijc.23458","article-title":"Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas.","volume":"122","author":"Hafkamp","year":"2008","journal-title":"Int J Cancer"},{"key":"R13-13-20210131","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/modpathol.2009.23","article-title":"P21 Cip1WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis.","volume":"22","author":"Hafkamp","year":"2009","journal-title":"Mod Pathol"},{"key":"R14-13-20210131","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1002\/ijc.22177","article-title":"Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer.","volume":"119","author":"Hammarstedt","year":"2006","journal-title":"Int J Cancer"},{"key":"R15-13-20210131","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.ejca.2010.04.016","article-title":"Relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer.","volume":"46","author":"Hong","year":"2010","journal-title":"Eur J Cancer"},{"key":"R16-13-20210131","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/sj.bjc.6605944","article-title":"Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy.","volume":"103","author":"Hong","year":"2011","journal-title":"Br J Cancer"},{"key":"R18-13-20210131","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/modpathol.2011.105","article-title":"Extracapsular extension is a poor predictor of disease recurrence in surgically treated oropharyngeal squamous cell carcinoma.","volume":"24","author":"Lewis","year":"2011","journal-title":"Mod Pathol"},{"key":"R21-13-20210131","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","article-title":"HPV-associated head and neck cancer: a virus-related cancer epidemic.","volume":"11","author":"Marur","year":"2010","journal-title":"Lancet Oncol"},{"key":"R22-13-20210131","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/(SICI)1097-0142(19990815)86:4<608::AID-CNCR9>3.0.CO;2-1","article-title":"Sarcomatoid carcinoma of the lung: a clinicopathologic study of 37 cases.","volume":"86","author":"Nakajima","year":"1999","journal-title":"Cancer"},{"key":"R25-13-20210131","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/ijc.22851","article-title":"Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis.","volume":"121","author":"Ragin","year":"2007","journal-title":"Int J Cancer"},{"key":"R26-13-20210131","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1002\/ijc.22355","article-title":"Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer.","volume":"120","author":"Reimers","year":"2007","journal-title":"Int J Cancer"},{"key":"R27-13-20210131","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/lary.20552","article-title":"Transoral laser microsurgery (TLM) adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors.","volume":"119","author":"Rich","year":"2009","journal-title":"Laryngoscope"},{"key":"R28-13-20210131","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1200\/JCO.2010.29.2904","article-title":"Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial.","volume":"28","author":"Rischin","year":"2010","journal-title":"J Clin Oncol"},{"key":"R29-13-20210131","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.oraloncology.2010.02.013","article-title":"Refining the diagnosis of oropharyngeal squamous cell carcinoma using human papillomavirus testing.","volume":"46","author":"Robinson","year":"2010","journal-title":"Oral Oncol"},{"key":"R30-13-20210131","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1200\/JCO.2009.23.1670","article-title":"Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma.","volume":"27","author":"Shi","year":"2009","journal-title":"J Clin Oncol"},{"key":"R31-13-20210131","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/cncr.20998","article-title":"Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years.","volume":"103","author":"Shiboski","year":"2005","journal-title":"Cancer"},{"key":"R32-13-20210131","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1208130","article-title":"The mutational landscape of head and neck squamous cell carcinoma.","volume":"333","author":"Stransky","year":"2011","journal-title":"Science"},{"issue":"suppl 1","key":"R34-13-20210131","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/j.jcv.2004.11.017","article-title":"Human papillomavirus (HPV) in head and neck cancer.","volume":"32","author":"Syrjanen","year":"2005","journal-title":"J Clin Virol"},{"key":"R35-13-20210131","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00000478-200202000-00002","article-title":"Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases.","volume":"26","author":"Thompson","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"R36-13-20210131","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/PAS.0b013e318220e59d","article-title":"High risk human papillomavirus E6E7 mRNA detection by a novel in situ hybridization assay strongly correlates with p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma.","volume":"35","author":"Ukpo","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"R37-13-20210131","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1016\/j.otohns.2009.04.014","article-title":"Defining molecular phenotypes of human papillomavirus-associated oropharyngeal squamous cell carcinoma: validation of three-class hypothesis.","volume":"141","author":"Weinberger","year":"2009","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00000478-201207000-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T20:35:33Z","timestamp":1642624533000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000478-201207000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0b013e3182583678","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}