{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:34:31Z","timestamp":1790393671275,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1097\/pas.0b013e31826cebad","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T11:57:16Z","timestamp":1358942236000},"page":"323-332","source":"Crossref","is-referenced-by-count":157,"title":["Double-hit B-cell Lymphomas With BCL6 and MYC Translocations Are Aggressive, Frequently Extranodal Lymphomas Distinct From BCL2 Double-hit B-cell Lymphomas"],"prefix":"10.1097","volume":"37","author":[{"given":"Raju K.","family":"Pillai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malini","family":"Sathanoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Branden","family":"Van Oss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Swerdlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20210131","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1182\/blood-2010-09-297879","article-title":"Double-hit B-cell lymphomas.","volume":"117","author":"Aukema","year":"2011","journal-title":"Blood"},{"key":"R2-2-20210131","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1038\/leu.2008.230","article-title":"Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkins Lymphoma Study Group (DSHNHL).","volume":"22","author":"Klapper","year":"2008","journal-title":"Leukemia"},{"key":"R3-2-20210131","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/leu.2008.281","article-title":"Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge.","volume":"23","author":"Boerma","year":"2009","journal-title":"Leukemia"},{"key":"R4-2-20210131","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1038\/sj.leu.2404856","article-title":"Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma.","volume":"21","author":"Iqbal","year":"2007","journal-title":"Leukemia"},{"key":"R5-2-20210131","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/10428190701742472","article-title":"Frequency of BCL2 and BCL6 translocations in follicular lymphoma: relation with histological and clinical features.","volume":"49","author":"Diaz-Alderete","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"R8-2-20210131","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood-2009-03-212191","article-title":"Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival.","volume":"114","author":"Johnson","year":"2009","journal-title":"Blood"},{"key":"R9-2-20210131","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3324\/haematol.11305","article-title":"The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24c-MYC rearrangement.","volume":"92","author":"Le Gouill","year":"2007","journal-title":"Haematologica"},{"key":"R10-2-20210131","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1200\/JCO.1999.17.5.1558","article-title":"Small noncleaved, non-Burkitts (Burkit-Like) lymphoma: cytogenetics predict outcome and reflect clinical presentation.","volume":"17","author":"Macpherson","year":"1999","journal-title":"J Clin Oncol"},{"key":"R11-2-20210131","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/leu.2008.344","article-title":"Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24c-MYC translocations.","volume":"23","author":"Niitsu","year":"2009","journal-title":"Leukemia"},{"key":"R12-2-20210131","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/PAS.0b013e3181cd3aeb","article-title":"B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.","volume":"34","author":"Snuderl","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"R13-2-20210131","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3324\/haematol.2008.005355","article-title":"Clinicopathological features of lymphomaleukemia patients carrying both BCL2 and MYC translocations.","volume":"94","author":"Tomita","year":"2009","journal-title":"Haematologica"},{"key":"R14-2-20210131","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/sj.leu.2404529","article-title":"Bastard C, Maingonnat C, et al. Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas.","volume":"21","author":"Bertrand","year":"2007","journal-title":"Leukemia"},{"key":"R15-2-20210131","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/modpathol.3800500","article-title":"Lymphoid neoplasms associated with concurrent t(14;18) and 8q24c-MYC translocation generally have a poor prognosis.","volume":"19","author":"Kanungo","year":"2006","journal-title":"Mod Pathol"},{"key":"R16-2-20210131","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/MOH.0b013e328353bbbd","article-title":"Biology of double-hit B-cell lymphomas.","volume":"19","author":"Lindsley","year":"2012","journal-title":"Curr Opin Hematol"},{"key":"R17-2-20210131","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/modpathol.2011.147","article-title":"B-cell lymphomas with MYC8q24 rearrangements and IGHBCL2t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome.","volume":"25","author":"Li","year":"2012","journal-title":"Mod Pathol"},{"key":"R18-2-20210131","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1309\/AJCP7YLDTJPLCE5F","article-title":"Double-Hit mature B-cell lymphomas show a common immunophenotype by flow cytometry that includes decreased CD20 expression.","volume":"134","author":"Wu","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"R19-2-20210131","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-065X.2012.01112.x","article-title":"Roles of BCL6 in normal and transformed germinal center B cells.","volume":"247","author":"Basso","year":"2012","journal-title":"Immunol Rev"},{"key":"R22-2-20210131","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"R25-2-20210131","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/modpathol.2010.76","article-title":"Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas.","volume":"23","author":"Seegmiller","year":"2010","journal-title":"Mod Pathol"},{"key":"R26-2-20210131","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/j.1365-2141.2005.05706.x","article-title":"G-banding and molecular cytogenetic analyses of marginal zone lymphoma.","volume":"130","author":"Aamot","year":"2005","journal-title":"Br J Haematol"},{"key":"R27-2-20210131","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF02982069","article-title":"Human herpes virus 8-negative primary effusion lymphoma in a patient with a ventriculoperitoneal shunt tube.","volume":"74","author":"Ashihara","year":"2001","journal-title":"Int J Hematol"},{"key":"R28-2-20210131","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000108319","article-title":"Molecular cytogenetics of IGH rearrangements in non-Hodgkin B-cell lymphoma.","volume":"118","author":"Bernicot","year":"2007","journal-title":"Cytogenet Genome Res"},{"key":"R29-2-20210131","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0165-4608(01)00548-9","article-title":"Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization.","volume":"132","author":"Dave","year":"2002","journal-title":"Cancer Genet Cytogenet"},{"key":"R30-2-20210131","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/gcc.10120","article-title":"Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma.","volume":"35","author":"Itoyama","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"R31-2-20210131","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1080\/10428190310001625674","article-title":"Molecular-cytogenetic characterization of non-Hodgkins lymphoma with double and cryptic translocations of the immunoglobulin heavy chain gene.","volume":"45","author":"Kanda-Akano","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"R32-2-20210131","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1182\/blood.V77.5.1057.1057","article-title":"MYC rearrangement and translocations involving band 8q24 in diffuse large cell lymphomas.","volume":"77","author":"Ladanyi","year":"1991","journal-title":"Blood"},{"key":"R33-2-20210131","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0165-4608(97)00391-9","article-title":"Translocation (3;13)(q27;q14): a nonrandom and probably secondary structural change in non-Hodgkin lymphomas.","volume":"103","author":"Lai","year":"1998","journal-title":"Cancer Genet Cytogenet"},{"key":"R34-2-20210131","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/sj.leu.2401059","article-title":"BCL6 rearrangement and mediastinal involvement in a case of B cell acute lymphoblastic leukemia.","volume":"12","author":"Rubnitz","year":"1998","journal-title":"Leukemia"},{"key":"R35-2-20210131","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cancergencyto.2005.12.013","article-title":"A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphomaleukemia and ataxia-telangiectasia.","volume":"168","author":"Sandlund","year":"2006","journal-title":"Cancer Genet Cytogenet"},{"key":"R36-2-20210131","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1182\/blood.V92.11.4269","article-title":"Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping.","volume":"92","author":"Sawyer","year":"1998","journal-title":"Blood"},{"key":"R37-2-20210131","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cancergencyto.2006.07.016","article-title":"A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma.","volume":"172","author":"Wang","year":"2007","journal-title":"Cancer Genet Cytogenet"},{"key":"R38-2-20210131","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2141.1986.tb02212.x","article-title":"Variant translocation t(8;22) and abnormalities of chromosome 15(q22) and 17(q12-21) in a Burkitts lymphomaleukaemia with disseminated intravascular coagulation.","volume":"64","author":"Daly","year":"1986","journal-title":"Br J Haematol"},{"key":"R39-2-20210131","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2169\/internalmedicine.50.4860","article-title":"Diffuse large B-cell lymphoma carrying both t(3; 7)(q27; p12) and t(8; 14)(q24; q32).","volume":"50","author":"Katsura","year":"2011","journal-title":"Intern Med"},{"key":"R40-2-20210131","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa055351","article-title":"A biologic definition of Burkitts lymphoma from transcriptional and genomic profiling.","volume":"354","author":"Hummel","year":"2006","journal-title":"N Engl J Med"},{"key":"R41-2-20210131","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa055759","article-title":"Molecular diagnosis of Burkitts lymphoma.","volume":"354","author":"Dave","year":"2006","journal-title":"N Engl JMed"},{"key":"R42-2-20210131","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3324\/haematol.13071","article-title":"Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitts lymphoma.","volume":"93","author":"Salaverria","year":"2008","journal-title":"Haematologica"},{"key":"R43-2-20210131","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/cncr.26433","article-title":"Prognostic value of MYC rearrangement in cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma.","volume":"118","author":"Lin","year":"2012","journal-title":"Cancer"},{"key":"R44-2-20210131","first-page":"585","article-title":"The negative prognostic impact of derivative 9 deletions in patients who received hydroxyurea treatment for chronic myelogenous leukemia in the chronic phase.","volume":"31","author":"Li","year":"2008","journal-title":"Onkologie"},{"key":"R45-2-20210131","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/modpathol.2009.168","article-title":"Diffuse large B-cell lymphoma associated with chronic inflammation as an incidental finding and new clinical scenarios.","volume":"23","author":"Loong","year":"2010","journal-title":"Mod Pathol"},{"key":"R46-2-20210131","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3960\/jslrt.51.7","article-title":"BCL2 and MYC dual-hit lymphomaleukemia.","volume":"51","author":"Tomita","year":"2011","journal-title":"J Clin Exp Hematop"},{"key":"R47-2-20210131","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/modpathol.2008.75","article-title":"BCL6 gene amplification3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation.","volume":"21","author":"Karube","year":"2008","journal-title":"Mod Pathol"},{"key":"R48-2-20210131","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1200\/JCO.2009.26.3947","article-title":"Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab.","volume":"28","author":"Barrans","year":"2010","journal-title":"J Clin Oncol"},{"key":"R49-2-20210131","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1309\/AJCPATUP1D0HGCUG","article-title":"Expression of LMO2 is associated with t(14;18)IGH-BCL2 fusion but not BCL6 translocations in diffuse large B-cell lymphoma.","volume":"134","author":"Durnick","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"R50-2-20210131","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3324\/haematol.2011.042531","article-title":"Follicular lymphoma grade 3B is a distinct neoplasm according to cytogenetic and immunohistochemical profiles.","volume":"96","author":"Horn","year":"2011","journal-title":"Haematologica"},{"key":"R51-2-20210131","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1525-1578(10)60564-8","article-title":"Molecular cytogenetic analyses of immunoglobulin loci in nodular lymphocyte predominant Hodgkins lymphoma reveal a recurrent IGH-BCL6 juxtaposition.","volume":"7","author":"Renne","year":"2005","journal-title":"J Mol Diagn"},{"key":"R52-2-20210131","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.beha.2011.02.002","article-title":"Follicular lymphoma grade 3B.","volume":"24","author":"Salaverria","year":"2011","journal-title":"Best Pract Res Clin Haematol"},{"key":"R53-2-20210131","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1182\/blood-2002-05-1592","article-title":"Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma.","volume":"101","author":"Wlodarska","year":"2003","journal-title":"Blood"},{"key":"R54-2-20210131","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3960\/jslrt.46.43","article-title":"Pathogenetic and clinical implications of non-immunoglobulin; BCL6 translocations in B-cell non-Hodgkins lymphoma.","volume":"46","author":"Ohno","year":"2006","journal-title":"J Clin Exp Hematop"},{"key":"R56-2-20210131","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/gcc.20246","article-title":"BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B.","volume":"44","author":"Bosga-Bouwer","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"R57-2-20210131","first-page":"4649","article-title":"BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgHBCL2.","volume":"29","author":"Gollub","year":"2009","journal-title":"Anticancer Res"},{"key":"R58-2-20210131","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/gcc.20831","article-title":"Several lymphoma-specific genetic events in parallel can be found in mature B-cell neoplasms.","volume":"50","author":"Bacher","year":"2011","journal-title":"Genes Chromosomes Cancer"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00000478-201303000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T06:32:18Z","timestamp":1618036338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000478-201303000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0b013e31826cebad","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}